Results 211 to 220 of about 19,208 (245)

Gene Mutation-Negative Malignant Melanoma in a Prepubertal Patient: A Clinical and Molecular Case Report. [PDF]

Genes (Basel)
Guźniczak A, Sosnowska-Sienkiewicz P, Szydłowski J, Kurzawa P, Januszkiewicz-Lewandowska D.   +4 more
europepmc   +1 more source

Genetic Landscape of Familial Melanoma. [PDF]

Genes (Basel)
Scarano C, Veneruso I, D'Argenio V.
europepmc   +1 more source

Melanin and Neurotransmitter Signalling Genes Are Differentially Co-Expressed in Growing Feathers of White and Rufous Barn Owls. [PDF]

Pigment Cell Melanoma Res
Ducrest AL, San-Jose LM, Neuenschwander S, Schmid-Siegert E, Simon C, Pagni M, Iseli C, Richter H, Guex N, Cumer T, Beaudoing E, Dupasquier M, Charruau P, Ducouret P, Xenarios I, Goudet J, Roulin A.   +16 more
europepmc   +1 more source

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MC1R Peptide Agonist Self-Assembles into a Hydrogel That Promotes Skin Pigmentation for Treating Vitiligo.

ACS Nano, 2023
Vitiligo, a common skin disease that seriously affects 0.5-2.0% of the worldwide population, lacks approved therapeutics due to a wide range of adverse side effects. As a key regulator of skin pigmentation, MC1R may be an effective therapeutic target for
Ci Zhu, Tingting Li, Zhuole Wang, Zenghui Li, Jiaying Wei, Hong Han, Dan Yuan, Minying Cai, Junfeng Shi   +8 more
semanticscholar   +1 more source

Genetic fine‐mapping reveals single nucleotide polymorphism mutations in the MC1R regulatory region associated with duck melanism

Molecular Ecology, 2023
Birds are among the most colourful terrestrial vertebrates, with various plumage colours and patterns. We conducted a genome‐wide association study (GWAS) on an intercross F2 population of Pekin ducks and mallards (n = 722) and identified a 1.57‐Mb ...
He-he Liu, Y. Xi, Qian Tang, J. Qi, Zhengkui Zhou, Zhanbao Guo, W. Fan, Jian Hu, Yaxi Xu, Suyun Liang, M. Xie, Jing Tang, Yunsheng Zhang, S. Hou   +13 more
semanticscholar   +1 more source

Abstract CT104: MC1R imaging and histology in the targeted imaging of melanoma for alpha-particle radiotherapy (TIMAR1) trial

Cancer Research, 2023
Purpose: Melanocortin 1 receptor (MC1R) has been shown in animal models to be a target for effective radionuclide therapy. This first-in-human clinical trial studied the safety and biodistribution of two novel MC1R-targeted imaging tracers designed to ...
Brenna M. Marks, M. Block, G. Johnson, C. Hruska, M. Pandey, A. Paulsen, M. Schultz, M. A. McDonald, Edwin A. Sagastume, Frances L. Johnson   +9 more
semanticscholar   +1 more source

Germline MC1R variants and frequency of somatic BRAF, NRAS, and TERT mutations in melanoma: Literature review and meta‐analysis

Molecular Carcinogenesis, 2021
Germline variants of the melanocortin‐1‐receptor (MC1R) gene are the most common genetic trait predisposing to cutaneous melanoma (CM). Here, we performed a literature review and meta‐analysis of the association between MC1R gene variants and the ...
I. Zanna, S. Caini, S. Raimondi, C. Saieva, G. Masala, D. Massi, E. Cocorocchio, P. Queirolo, I. Stanganelli, S. Gandini   +9 more
semanticscholar   +1 more source

MC1R CpG island regulates MC1R expression and is methylated in a subset of melanoma tumours

Pigment Cell & Melanoma Research, 2018
AbstractMelanocortin 1 receptor (MC1R) is a G protein‐coupled receptor expressed in melanocytes where it plays an important role in skin pigmentation and in the UV response, and has implications in melanoma development. Here we show that methylation of a CpG island (CGI) within the MC1R gene can control expression of MC1R in melanoma. This CGI overlaps
Timothy Budden, Nikola A. Bowden
openaire   +2 more sources

mc1rPathway Regulation of Zebrafish Melanosome Dispersion

Zebrafish, 2008
Zebrafish rapidly alter their pigmentation in response to environmental changes. For black melanocytes, this change is due to aggregation or dispersion of melanin in the cell. Dispersion and aggregation are controlled by intracellular cyclic adenosine monophosphate (cAMP) levels, which increase upon stimulation by alpha melanocyte-stimulating hormone ...
Jennifer, Richardson, Pia Rengtved, Lundegaard, Natalie L, Reynolds, Julia R, Dorin, David J, Porteous, Ian J, Jackson, E Elizabeth, Patton   +6 more
openaire   +2 more sources

MC1R c.310G>- and c.871G > A determine the coat color of Kumamoto sub-breed of Japanese Brown cattle.

Animal science journal = Nihon chikusan Gakkaiho, 2020
Coat color is one of the important factors characterizing breeds for domestic animals. Melanocortin 1 receptor (MC1R) is a representative responsible gene for this phenotype.
Hirokazu Matsumoto, Masatake Kojya, Hiroko Takamuku, Satoshi Kimura, A. Kashimura, Saki Imai, Kenji Yamauchi, S. Ito   +7 more
semanticscholar   +1 more source