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MC3R links nutritional state to childhood growth and the timing of puberty
Nature, 2021 The state of somatic energy stores in metazoans is communicated to the brain, which regulates key aspects of behaviour, growth, nutrient partitioning and development1. The central melanocortin system acts through melanocortin 4 receptor (MC4R) to control appetite, food intake and energy expenditure2.
Brian Lam, Alice Williamson, Sarah Finer
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VTA MC3R neurons control feeding in an activity- and sex-dependent manner in mice [PDF]
Neuropharmacology, 2021 AbstractIncreasing evidence indicates that the melanocortin and mesolimbic dopamine systems interact to regulate feeding and body weight. Because melanocortin-3 receptors (MC3R) are highly expressed in the ventral tegmental area (VTA), we tested whether VTA neurons expressing these receptors (VTA MC3R neurons) control feeding and body weightin vivo. We
Anna I Dunigan +2 more
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A role for MC3R in modulating lung inflammation [PDF]
Pulmonary Pharmacology and Therapeutics, 2008 In this study we set out to ascertain whether melanocortin peptides could be potential therapeutic agents in allergic and non-allergic models of lung inflammation by identifying the receptor(s) involved using a molecular, genetic and pharmacological approach.
Simon C Pitchford +2 more
exaly +5 more sources