Results 171 to 180 of about 4,530 (193)

Leptin in Association With Common Variants of MC3R Mediates Hypertension [PDF]

American Journal of Hypertension, 2014
Recent research illustrates the role of central melanocortin signaling and leptin in the regulation of arterial blood pressure in animal models. Unraveling the genetic basis of interactions between melanocortin and leptin in humans will provide new insight into the regulation of arterial pressure.Our study population consisted of 332 Kuwaiti natives ...
Motasem Melhem, Prashantha Hebbar, Gaurav Thareja   +2 more
exaly   +3 more sources

Some of the next articles are maybe not open access.

Related searches:

1608-P: Phenotype of Liver-Specific MC3R Knockout Mice

Diabetes, 2023
The melanocortin 3 receptor (MC3R) is a key regulator of energy homeostasis and feeding behavior. Global Mc3r knockout mice exhibit greater fat mass and reduced lean mass. Our previous research has found that Mc3r transcripts can be detected in liver and the MC3R deficiency phenotype is partially reversed in liver-specific MC3R recovery mice on a chow ...
JOCELYN CHEN, TUSHAR P. PATEL, ARAD JAIN, DIANA ELIZONDO, ELIZABETH K. ALTMAN, NICOL TUGARINOV, MELANIE HOLLIS, ROBIN ROBERSON, ALEXANDRE CARON, JOEL K. ELMQUIST, JACK A. YANOVSKI   +10 more
openaire   +1 more source

The interaction of MC3R and MC4R with MRAP2a in rainbow trout (Oncorhynchus mykiss)

Fish Physiology and Biochemistry, 2022
Melanocortin 3 and 4 receptors are two important neural G protein-coupled receptors that regulate energy homeostasis in vertebrates. Melanocortin receptor accessory protein 2 (MRAP2) is also involved in the regulation of food intake and body weight as a variable regulator of melanocortin receptors. Rainbow trout (Oncorhynchus mykiss) is a valuable cold-
Yang Li
exaly   +3 more sources

Liver-Specific Reactivation of MC3R Partially Reverses the Obesity of MC3R Deficiency

Diabetes, 2018
The Melanocortin 3 Receptor (MC3R) regulates appetite, food intake, and energy expenditure in humans and mice. MC3R is primarily expressed in the hypothalamus and other CNS regions but is also present in peripheral tissues including the liver. Total body knockouts of MC3R have a distinct obese phenotype of increased fat mass with decreased lean mass ...
NOAH J. LEVI, JOO YUN JUN, TUSHAR P. PATEL, ANDREW J. UHLMAN, ROBIN ROBERSON, JACK A. YANOVSKI   +5 more
openaire   +1 more source

Prevalence of rare MC3R variants in obese cases and lean controls

Endocrine, 2012
The role of mutations in the melanocortin-3 receptor (MC3R) gene, which is implicated in the regulation of energy homeostasis, is still under debate. Animal studies have clearly proven that, together with the melanocortin-4 receptor (MC4R), the MC3R is a critical receptor for melanocortin peptides within the leptin-melanocortin signaling cascade ...
Kim Van Hoorenbeeck, Wim Van Hul
exaly   +4 more sources

The regulation of food intake by selective stimulation of the type 3 melanocortin receptor (MC3R) [PDF]

Peptides, 2006
High levels of binding sites for melanocortin peptides exist within the arcuate nucleus, and a functional response to melanocortin peptides has been demonstrated in arcuate POMC neurons. Because the MC3R is thought to function as an inhibitory autoreceptor on POMC neurons, we reasoned that peripheral injections of MC3R-specific agonists would act ...
Roger D Cone, Victor J Hruby
exaly   +3 more sources

Melanocortin 3 receptor (MC3R) gene variants in extremely obese women

International Journal of Obesity, 2000
Following several reports of linkage of obesity related phenotypes to human chromosome 20q we sought to determine whether variations of the melanocortin 3 receptor (MC3R) gene are associated with obesity.We screened the MC3R gene coding region and approximately 2 kb of 5' and 3' flanking sequences for DNA variants in unrelated extremely obese women and
W D, Li, E J, Joo, E B, Furlong, M, Galvin, K, Abel, C J, Bell, R A, Price   +6 more
exaly   +3 more sources

Mapping of a Novel Susceptibility Locus Suggests a Role for MC3R and CTSZ in Human Tuberculosis [PDF]

American Journal of Respiratory and Critical Care Medicine, 2008
Tuberculosis remains a major cause of morbidity and mortality in the developing world. A better understanding of the mechanisms of disease protection could allow novel strategies to disease management and control.To identify human genomic loci with evidence of linkage to tuberculosis susceptibility and, within these loci, to identify individual genes ...
Graham S Cooke, Christian Lienhardt, Per Gustafson   +2 more
exaly   +5 more sources

Peripheral Melanocortin 3 Receptor (MC3R) Regulates Hepatic Autophagy in Obesity

Diabetes, 2018
We have previously reported homozygosity for two MC3R SNPs (C17A+G241A) that partially inactive MC3R increases adiposity in humans and mouse models. However, the precise mechanisms by which hypoactive MC3R alters metabolic homeostasis remain unclear. Given the essential role of hepatic autophagy in cellular mechanisms of obesity, we hypothesized that ...
JOO YUN JUN, ARNOLD Y. SEO, TUSHAR P. PATEL, ANDREW J. UHLMAN, NOAH J. LEVI, ROBIN ROBERSON, JACK A. YANOVSKI   +6 more
openaire   +1 more source

Associations of MC3R Polymorphisms With Physical Activity in South African Adolescents

Journal of Physical Activity and Health, 2013
Background:There is evidence demonstrating that the contribution of sedentary behavior and effect of physical activity on metabolic phenotypes is mediated by polymorphisms in genes.Methods:The type and frequency of physical activity was assessed by means of structured questionnaires in 1555 South African school learners.
Yako, Yandiswa Y, Hassan, Mogamat Shafick, Erasmus, Rajiv T, Van der Merwe, Lize, Janse van Rensburg, Susan, Matsha, Tandi Edith   +5 more
openaire   +2 more sources