The MCM2-7 Complex: Roles beyond DNA Unwinding [PDF]
BiologyThe MCM2-7 complex is a hexameric protein complex that serves as a DNA helicase. It unwinds the DNA double helix during DNA replication, thereby providing the single-stranded replication template.
Brooke D. Rankin, Susannah Rankin
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Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1. [PDF]
Nat Struct Mol Biol, 2017 To initiate DNA replication, the origin recognition complex (ORC) and Cdc6 load an Mcm2–7 double hexamer onto DNA. Without ATP hydrolysis, ORC–Cdc6 recruits one Cdt1-bound Mcm2–7 hexamer, thus forming an ORC–Cdc6–Cdt1–Mcm2–7 (OCCM) helicase-loading ...
Yuan Z +11 more
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Role of MCM2–7 protein phosphorylation in human cancer cells [PDF]
Cell & Bioscience, 2018 A heterohexameric complex composed of minichromosome maintenance protein 2–7 (MCM2–7), which acts as a key replicative enzyme in eukaryotes, is crucial for initiating DNA synthesis only once per cell cycle. The MCM complex remains inactive through the G1
Liangru Fei, Hongtao Xu
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The assembly of the MCM2-7 hetero-hexamer and its significance in DNA replication. [PDF]
Biochem Soc Trans, 2023 The mini-chromosome maintenance proteins 2–7 (MCM2–7) hexamer is a protein complex that is key for eukaryotic DNA replication, which occurs only once per cell cycle.
Hatoyama Y, Kanemaki MT.
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A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding [PDF]
eLife, 2019 Licensing of eukaryotic origins of replication requires DNA loading of two copies of the Mcm2-7 replicative helicase to form a head-to-head double-hexamer, ensuring activated helicases depart the origin bidirectionally.
Kanokwan Champasa +4 more
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ITRAQ-based quantitative proteomic analysis reveals that VPS35 promotes the expression of MCM2-7 genes in HeLa cells [PDF]
Scientific Reports, 2022 Vacuolar protein sorting 35 (VPS35) is a major component of the retromer complex that regulates endosomal trafficking in eukaryotic cells. Recent studies have shown that VPS35 promotes tumor cell proliferation and affects the nuclear accumulation of its ...
Xian Hong +9 more
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MCM2–7-dependent cohesin loading during S phase promotes sister-chromatid cohesion [PDF]
eLife, 2018 DNA replication transforms cohesin rings dynamically associated with chromatin into the cohesive form to establish sister-chromatid cohesion. Here, we show that, in human cells, cohesin loading onto chromosomes during early S phase requires the ...
Ge Zheng +3 more
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Complejo mcm2-7. Revisión bibliográfica [PDF]
Odontoestomatología, 2018 Resumen: La formación de nuevas células se genera a partir de células preexistentes a través de una serie ordenada de eventos denominada ciclo celular.
Delmira Apellániz +3 more
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Mechanism and timing of Mcm2-7 ring closure during DNA replication origin licensing. [PDF]
Nat Struct Mol Biol, 2017 The opening and closing of two ring-shaped Mcm2–7 DNA helicases is necessary to license eukaryotic origins of replication, although the mechanisms controlling these events are unclear.
Ticau S +5 more
europepmc +4 more sources
Changes in MCM2–7 proteins at senescence
Genes and Genetic Systems, 2019 Cellular aging is characterized by the loss of DNA replication capability and is mainly brought about by various changes in chromatin structure. Here, we examined changes in MCM2-7 proteins, which act as a replicative DNA helicase, during aging of human ...
Yukio Ishimi
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