Results 1 to 10 of about 3,352 (198)

Evaluating CK20 and MCPyV Antibody Clones in Diagnosing Merkel Cell Carcinoma. [PDF]

Endocr Pathol
Merkel cell carcinoma (MCC) is diagnosed through histopathological and immunohistochemical examination of biopsies from skin or other organs. Its distinguishing features include perinuclear dot-like staining with Cytokeratin 20 (CK20) and detection of ...
Yeni Erdem B, Baykal C, Ozluk Y, Ahmed MA, Kozanoglu E, Saip P, Buyukbabani N, Ozturk Sari S.   +7 more
europepmc   +6 more sources

Merkel Cell Polyomavirus (MCPyV) and Its Possible Role in Head and Neck Cancers. [PDF]

Biomedicines
Despite significant progress in its prevention, diagnosis, and treatment, head and neck cancer (HNC) remains a major global health issue due to its multifactorial pathogenesis.
Passerini S, Messina S, Moens U, Pietropaolo V.   +3 more
europepmc   +6 more sources

Merkel Cell Carcinoma of Unknown Primary: Immunohistochemical and Molecular Analyses Reveal Distinct UV-Signature/MCPyV-Negative and High Immunogenicity/MCPyV-Positive Profiles [PDF]

Cancers, 2021
Simple Summary Merkel cell carcinomas (MCCs) of unknown primary are defined as deep-seated tumors without an associated cutaneous tumor. Although the distinction has important clinical implications, it remains unclear whether these tumors represent ...
Piotr Donizy, Joanna Wróblewska, Dora Dias‐Santagata, Katarzyna Woźnica, Przemysław Biecek, Mark C. Mochel, Cheng-Lin Wu, Janusz Kopczyński, Małgorzata Pieniążek, Janusz Ryś, Andrzej Marszałek, Mai P. Hoang   +11 more
semanticscholar   +5 more sources

MCPyV small T antigen enhances HPV16 oncogene expression, promotes Ca Ski cell proliferation, and reduces 5-fluorouracil-induced apoptosis in cervical cancer cells. [PDF]

Infect Med (Beijing)
Highlights • MCPyV sT reduced 5-FU cytotoxicity, increased the IC50, and improved cell viability across all tested concentrations, indicating reduced chemosensitivity.• MCPyV sT protected against 5-FU-induced apoptosis in transfected cells, demonstrating
Pakdel T, Kargar M, Farhadi A, Aghdaei MH, Kohan L.   +4 more
europepmc   +3 more sources

Human polyomaviruses JCPyV and MCPyV in urothelial cell carcinoma: a single institution experience [PDF]

Frontiers in Oncology, 2023
Objective Urothelial cell carcinoma (UCC) is the most common type of urinary bladder. JCPyV and BKPyV have been detected in the urine and tissue of urothelial cell carcinomas (UCC) in immunocompetent patients.
Faisal Klufah, Ghalib Mobaraki, Shuai Shi, Tom Marcelissen, Raed Alharbi, Mousa Mobarki, Shaia Almalki, Joep G.H. van Roermund, Axel zur Hausen, Iryna Samarska   +9 more
semanticscholar   +5 more sources

Prevalence of Merkel Cell Polyomavirus (MCPyV) in the Oral Cavity Biopsies in Northern Iran [PDF]

Asian Pacific Journal of Cancer Prevention, 2021
Objective: Infection with human tumor viruses is one of the hypothesized causes of cancer. The current investigation aimed to explore the presence and quantitative analysis of a new human tumor virus, Merkel cell polyomavirus (MCPyV) in tissue samples of
Mina Hasani Estalkhi, Maryam Seyed Majidi, Farzin Sadeghi, Mohammad Chehrazi, Arghavan Zebardast, Ali Hasanzadeh, Yousef Yahyapour   +6 more
semanticscholar   +4 more sources

Clinical-Pathological Evaluation and Prognostic Analysis of 228 Merkel Cell Carcinomas Focusing on Tumor-Infiltrating Lymphocytes, MCPYV Infection and ALK Expression [PDF]

Endocrine pathology, 2022
Merkel cell carcinoma is a rare and aggressive primary neuroendocrine carcinoma of the skin, whose pathogenesis can be traced back to UV radiation damage or Merkel cell polyomavirus (MCPyV) infection.
Federica Santoro, Francesca Maletta, Renato Parente, Jessica Fissore, Cristian Tampieri, Leonardo Santoro, Nadia Birocco, Franco Picciotto, Pietro Quaglino, Marco Volante, Sofia Asioli, Rebecca Senetta, Mauro Papotti   +12 more
openalex   +2 more sources

Merkel cell carcinoma from renal transplant recipients are mostly MCPyV‐negative and are frequently associated with squamous cell carcinomas or precursors [PDF]

Journal of the European Academy of Dermatology and Venereology, 2023
Dear Editor, Merkel cell carcinoma (MCC), that is primary cutaneous neuroendocrine carcinoma is a rare skin cancer.1 Main risk factors are UV exposure and immunosuppression.1 In 2008, Feng et al.2 identified genomic integration of the Merkel cell ...
Margaux Pacaud, Thibault Kervarrec, Julien Masliah‐Planchon, Anne Tallet, Christine Collin, Serge Guyétant, Philippe Gatault, Peggy Perrin, Jérôme Olagne, Isabelle Étienne, Arnaud François, Léonard Golbin, Cécile Le Naourès, Marie‐Christine Moal, Laurent Doucet, Jean‐Philippe Rerolle, Angélique Guillaudeau, Valérie Châtelet, François Comoz, Pierre‐François Westeel, C. Cordonnier, Elodie Miquelestorena‐Standley, Antoine Touzé, Françoise Arnold, M. Samimi, Matthias Büchler   +25 more
openalex   +2 more sources

Detection Analysis and Study of Genomic Region Variability of JCPyV, BKPyV, MCPyV, HPyV6, HPyV7 and QPyV in the Urine and Plasma of HIV-1-Infected Patients [PDF]

Viruses, 2022
Since it was clearly established that HIV/AIDS predisposes to the infection, persistence or reactivation of latent viruses, the prevalence of human polyomaviruses (HPyVs) among HIV-1-infected patients and a possible correlation between HPyVs and HIV sero-
Sara Passerini, Carla Prezioso, Annalisa Prota, Giulia Babini, Luigi Coppola, A Lodi, Anna Chiara Epifani, Loredana Sarmati, Massimo Andreoni, Ugo Moens, Valeria Pietropaolo, Marco Ciotti   +11 more
openalex   +2 more sources

Glypican-3 (GPC3) is associated with MCPyV-negative status and impaired outcome in Merkel Cell Carcinoma [PDF]

bioRxiv, 2022
Background Merkel cell carcinoma (MCC) is an aggressive skin cancer, related to the Merkel Cell Polyomavirus (MCPyV) in 80% of cases. Immune checkpoint inhibitors provide sustained benefit in about half of MCC patients with advanced disease.
Sujatha Muralidharan, Thibault Kervarrec, Glen J. Weiss, M. Samimi   +3 more
semanticscholar   +4 more sources