A short intrinsically disordered domain of MCPyV ALTO regulates TBK1 signaling during MCPyV infection. [PDF]
J VirolMerkel cell polyomavirus (MCPyV) is an oncogenic human polyomavirus that latently infects most adults. Although the causative link between MCPyV and Merkel cell carcinoma is well established, the molecular mechanisms that govern viral latency and prevent
Senay TE +4 more
europepmc +3 more sources
Current In Vitro and In Vivo Models to Study MCPyV-Associated MCC
Viruses, 2022 Merkel cell polyomavirus (MCPyV) is the only human polyomavirus currently known to cause human cancer. MCPyV is believed to be an etiological factor in at least 80% of cases of the rare but aggressive skin malignancy Merkel cell carcinoma (MCC). In these
Amanda S. W. Loke +2 more
doaj +4 more sources
Prevalence of MCPyV, HPyV6, HPyV7 and TSPyV in Actinic Keratosis Biopsy Specimens [PDF]
Viruses, 2022 To date, 14 human polyomaviruses (HPyVs) have been identified using high-throughput technologies. Among them, MCPyV, HPyV6, HPyV7 and TSPyV present a skin tropism, but a causal role in skin diseases has been established only for MCPyV as a causative ...
Carla Prezioso +9 more
semanticscholar +10 more sources
CRISPR/Cas9 targeting of MCPyV T antigen in Merkel tumors [PDF]
bioRxiv, 2021 Merkel cell carcinoma (MCC) is a rare, aggressive skin cancer caused either by Merkel cell polyomavirus (MCPyV) T antigen gene expression, post integration (∼80% cases), or by UV mediated DNA damage.
Reety Arora +2 more
semanticscholar +3 more sources
Detection of Merkel Cell Polyomavirus (MCPyV) DNA and Transcripts in Merkel Cell Carcinoma (MCC) [PDF]
Pathogens, 2023 Merkel cell polyomavirus (MCPyV) is the etiological agent of the majority of Merkel cell carcinoma (MCC): a rare skin tumor. To improve our understanding of the role of MCPyV in MCCs, the detection and analysis of MCPyV DNA and transcripts were performed
Sara Passerini +8 more
semanticscholar +7 more sources
Oncotarget, 2015 Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine carcinoma, associated with the Merkel cell polyomavirus (MCPyV) in 80% of cases. To define the genetic basis of MCCs, we performed exome sequencing of 49 MCCs.
Gerald Goh +13 more
semanticscholar +5 more sources
MCPyV Co-Immunoprecipitation Protocol v2 [PDF]
protocols.io, 2018 Kristine N. Dye
semanticscholar +3 more sources
No detectable truncating mutations in large T antigen (LT-Ag) sequence of Merkel cell polyomavirus (MCPyV) DNA obtained from porocarcinomas [PDF]
Infectious Agents and CancerMerkel cell polyomavirus (MCPyV) is associated with Merkel cell carcinoma (MCC). In tumor cells the MCPyV large T antigen (LT-Ag) is frequently found truncated and this is considered a major tumor-specific signature.
Rosaria Arvia +5 more
openalex +2 more sources
Prevalence and viral loads of polyomaviruses BKPyV, JCPyV, MCPyV, TSPyV and NJPyV and hepatitis viruses HBV, HCV and HEV in HIV-infected patients in China [PDF]
Scientific Reports, 2020 Human polyomaviruses (PyVs) and hepatitis viruses are often more prevalent or persistent in human immunodeficiency virus (HIV)-infected persons and the associated diseases are more abundant than in immunocompetent individuals.
Xianfeng Zhou +9 more
openalex +2 more sources
4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2H-phenyl-1-phthalazinone Inhibits MCPyV T Antigen Expression in Merkel Cell Carcinoma Independent of Aurora Kinase A [PDF]
Cancers, 2023 Simple Summary Treatment of Merkel cell carcinoma—a deadly skin cancer frequently caused by the Merkel cell polyomavirus—still poses challenges. Since the tumor cells depend on expression of viral oncogenes—named T antigens—targeting the expression of ...
Roland Houben +8 more
openalex +2 more sources