Results 31 to 40 of about 3,352 (198)

MCPyV TAg-specific Polyclonal Autologous CD8-positive T Cells [PDF]

Definitions, 2020
A preparation of polyclonal autologous CD8 positive T-lymphocytes specific for the Merkel cell polyomavirus (MCPyV) T antigen (TAg) with potential antineoplastic activity.

semanticscholar   +2 more sources

Merkel cell polyomavirus in lung carcinogenesis: evidence and controversy [PDF]

Frontiers in Oncology
Lung cancer (LC) has been recognized as the leading cause of cancer mortality on a global scale. Although tobacco smoking is predominantly associated with LC (~85%), approximately 15-25% of lung cancers occur in non-smokers.
Changlong Zhou, Liang Lu, Maohong Hu, Tetsuro Suzuki, Xianfeng Zhou   +4 more
doaj   +2 more sources

Quantitative analysis of Merkel cell polyomavirus (MCPyV) genome in non-melanoma skin cancer and normal tumor margins [PDF]

Brazilian Journal of Microbiology, 2022
Ali Hasanzadeh, Farzin Sadeghi, Ghodsieh Kamrani, Neda Mohammadi, Zeinab Vosough, Mohammad Ranaee, Alijan Tabarraei, Yousef Yahyapour   +7 more
semanticscholar   +4 more sources

Opening new roads for MCPyV [PDF]

Blood, 2011
In this issue of Blood, Pancaldi et al report on the latent presence of large T antigen (LTag) sequences of the Merkel cell polyomavirus (MCPyV) in buffy coats of healthy individuals ...
Axel zur Hausen
openalex   +3 more sources

Small T Oncoprotein of Merkel Cell Polyomavirus Attenuates Cisplatin-Induced Apoptosis and Enhances E1, E6/E7, MMP-1, and Ki-67 Expression in HeLa Cervical Cancer Cells [PDF]

Advanced Pharmaceutical Bulletin
Purpose: Cervical cancer (CxCa) is primarily caused by high-risk human papillomaviruses (hrHPV), which disrupt p53 and pRb regulation, leading to uncontrolled growth and progression.
Fatemeh Pakdel, Seyed Masoud Hosseini, Neda Soleimani, Ali Farhadi   +3 more
doaj   +2 more sources

RB1 inactivation in cutaneous carcinomas. [PDF]

Histopathology
Among skin carcinomas, recurrent RB1 inactivation is observed in Merkel cell carcinoma, in a subset of squamous cell carcinoma with bowenoid morphology, in sebaceous carcinoma and in the recently described Wnt/beta‐catenin rosette‐forming carcinoma.
Liv T, Touzé A, Schrama D, Guyétant S, Samimi M, Tetzlaff MT, Wood BA, Harms PW, Kervarrec T.   +8 more
europepmc   +2 more sources

P3.236 Study of genital cancer aetiology: association of human papilomavirus (HPV) and merkel cell polyomavyrus (MCPYV) [PDF]

Sexually Transmitted Infections, 2017
WM Rocha, CF Baez, LA Afonso, FN Carestiato, RB Varella, SMB Cavalcanti   +5 more
openalex   +2 more sources

Characterization of molecular mechanisms driving Merkel cell polyomavirus oncogene transcription and tumorigenic potential.

PLoS Pathogens, 2023
Merkel cell polyomavirus (MCPyV) is associated with approximately 80% of cases of Merkel cell carcinoma (MCC), an aggressive type of skin cancer. The incidence of MCC has tripled over the past twenty years, but there are currently very few effective ...
June F Yang, Wei Liu, Jianxin You
doaj   +3 more sources

Merkel Cell Carcinoma: Evolving Therapeutics, Continued Challenges. [PDF]

Head Neck
ABSTRACT Background Merkel Cell Carcinoma (MCC) is a rare, aggressive neuroendocrine malignancy with rising incidence, influenced by ultraviolet (UV) radiation and Merkel cell polyomavirus (MCPyV). Methods This review summarizes recent advances in MCC management, based on an analysis of current literature, focusing on immune checkpoint inhibitors (ICIs)
Holley HA, Lyons M, O'Sullivan B, Shine N, Woods R, McArdle O, O'Neill JP.   +6 more
europepmc   +2 more sources

Tertiary Lymphoid Structures and Chemokine Landscape in Virus-Positive and Virus-Negative Merkel Cell Carcinoma

Frontiers in Oncology, 2022
Tertiary lymphoid structures (TLSs) are used as biomarkers in many cancers for predicting the prognosis and assessing the response to immunotherapy. In Merkel cell carcinoma (MCC), TLSs have only been examined in MCPyV-positive cases.
Motoki Nakamura, Tetsuya Magara, Shinji Kano, Akihiro Matsubara, Hiroshi Kato, Akimichi Morita   +5 more
doaj   +1 more source