Results 41 to 50 of about 3,352 (198)

T-helper cell-mediated proliferation and cytokine responses against recombinant Merkel cell polyomavirus-like particles. [PDF]

PLoS ONE, 2011
The newly discovered Merkel Cell Polyomavirus (MCPyV) resides in approximately 80% of Merkel cell carcinomas (MCC). Causal role of MCPyV for this rare and aggressive skin cancer is suggested by monoclonal integration and truncation of large T (LT) viral ...
Arun Kumar, Tingting Chen, Sari Pakkanen, Anu Kantele, Maria Söderlund-Venermo, Klaus Hedman, Rauli Franssila   +6 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer. [PDF]

Mol Oncol
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Jeremian R, Sivachandran S, Galati M, Ramchatesingh B, Rijal H, Hanna J, Netchiporouk E, Chergui M, Redpath M, Abou Setah S, Litvinov IV.   +10 more
europepmc   +2 more sources

From Merkel Cell Polyomavirus Infection to Merkel Cell Carcinoma Oncogenesis

Frontiers in Microbiology, 2021
Merkel cell polyomavirus (MCPyV) infection causes near-ubiquitous, asymptomatic infection in the skin, but occasionally leads to an aggressive skin cancer called Merkel cell carcinoma (MCC).
Nathan A. Krump, Jianxin You
doaj   +1 more source

Decreased IgG Antibody Response to Viral Protein Mimotopes of Oncogenic Merkel Cell Polyomavirus in Sera From Healthy Elderly Subjects

Frontiers in Immunology, 2021
Merkel cell polyomavirus (MCPyV) is the main causative agent of Merkel cell carcinoma (MCC), a rare but aggressive skin tumor with a typical presentation age >60 years. MCPyV is ubiquitous in humans.
Chiara Mazziotta, Chiara Mazziotta, Carmen Lanzillotti, Carmen Lanzillotti, Marcello Govoni, Giulia Pellielo, Elisa Mazzoni, Mauro Tognon, Fernanda Martini, Fernanda Martini, John Charles Rotondo, John Charles Rotondo   +11 more
doaj   +1 more source

Seroprevalence of Merkel cell polyomavirus in the general rural population of Anyang, China. [PDF]

PLoS ONE, 2014
BACKGROUND: Despite the probably causal link between Merkel cell polyomavirus (MCPyV) infection and Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy, little is known about the seroepidemiology of MCPyV among healthy adults in China ...
Chanyuan Zhang, Fangfang Liu, Zhonghu He, Qiuju Deng, Yaqi Pan, Ying Liu, Chaoting Zhang, Tao Ning, Chuanhai Guo, Yongmei Liang, Ruiping Xu, Lixin Zhang, Hong Cai, Yang Ke   +13 more
doaj   +1 more source

Serum Antibodies Against the Oncogenic Merkel Cell Polyomavirus Detected by an Innovative Immunological Assay With Mimotopes in Healthy Subjects

Frontiers in Immunology, 2021
Merkel cell polyomavirus (MCPyV), a small DNA tumor virus, has been detected in Merkel cell carcinoma (MCC) and in normal tissues. Since MCPyV infection occurs in both MCC-affected patients and healthy subjects (HS), innovative immunoassays for detecting
Chiara Mazziotta, Carmen Lanzillotti, Elena Torreggiani, Lucia Oton-Gonzalez, Maria Rosa Iaquinta, Elisa Mazzoni, Pauline Gaboriaud, Antoine Touzé, Ettore Silvagni, Marcello Govoni, Fernanda Martini, Mauro Tognon, John Charles Rotondo   +12 more
doaj   +1 more source

Prevalence of Merkel Cell Polyomavirus in Normal and Lesional Skin: A Systematic Review and Meta-Analysis

Frontiers in Oncology, 2022
The prevalence of Merkel cell polyomavirus(MCPyV) in Merkel cell carcinoma(MCC) and non-MCC skin lesions and its possible role in the etiology of other skin diseases remain controversial.
Wilson A. Wijaya, Yu Liu, Yong Qing, Zhengyong Li   +3 more
doaj   +1 more source

Detection of Merkel cell polyomavirus in cervical squamous cell carcinomas and adenocarcinomas from Japanese patients

Virology Journal, 2012
Background Merkel cell polyomavirus (MCPyV) was identified originally in Merkel cell carcinoma (MCC), a rare form of human skin neuroendocrine carcinoma. Evidence of MCPyV existence in other forms of malignancy such as cutaneous squamous cell carcinomas (
Imajoh Masayuki, Hashida Yumiko, Nemoto Yuiko, Oguri Hiroyoshi, Maeda Nagamasa, Furihata Mutsuo, Fukaya Takao, Daibata Masanori   +7 more
doaj   +1 more source

Significantly Low Levels of IgG Antibodies Against Oncogenic Merkel Cell Polyomavirus in Sera From Females Affected by Spontaneous Abortion

Frontiers in Microbiology, 2021
Merkel cell polyomavirus (MCPyV) is a small DNA tumor virus ubiquitous in humans. MCPyV establishes a clinically asymptomatic lifelong infection in healthy immunocompetent individuals.
Chiara Mazziotta, Chiara Mazziotta, Giulia Pellielo, Mauro Tognon, Fernanda Martini, Fernanda Martini, John Charles Rotondo, John Charles Rotondo   +7 more
doaj   +1 more source

Detection of Merkel Cell Polyomavirus DNA in Serum Samples of Healthy Blood Donors

Frontiers in Oncology, 2017
Merkel cell polyomavirus (MCPyV) has been detected in 80% of Merkel cell carcinomas (MCC). In the host, the MCPyV reservoir remains elusive. MCPyV DNA sequences were revealed in blood donor buffy coats.
Elisa Mazzoni, John C. Rotondo, Luisa Marracino, Rita Selvatici, Ilaria Bononi, Elena Torreggiani, Antoine Touzé, Fernanda Martini, Mauro G. Tognon   +8 more
doaj   +1 more source