Results 51 to 60 of about 3,352 (198)

Merkel Cell Polyomavirus DNA Replication Induces Senescence in Human Dermal Fibroblasts in a Kap1/Trim28-Dependent Manner

mBio, 2020
Merkel cell polyomavirus (MCPyV) is the only polyomavirus known to be associated with tumorigenesis in humans. Similarly to other polyomaviruses, MCPyV expresses a large tumor antigen (LT-Ag) that, together with a small tumor antigen (sT-Ag), contributes
Svenja Siebels, Manja Czech-Sioli, Michael Spohn, Claudia Schmidt, Juliane Theiss, Daniela Indenbirken, Thomas Günther, Adam Grundhoff, Nicole Fischer   +8 more
doaj   +1 more source

Merkel cell polyomavirus large T antigen binding to pRb promotes skin hyperplasia and tumor development.

PLoS Pathogens, 2022
Clear evidence supports a causal link between Merkel cell polyomavirus (MCPyV) and the highly aggressive human skin cancer called Merkel cell carcinoma (MCC).
Megan E Spurgeon, Jingwei Cheng, Ella Ward-Shaw, Frederick A Dick, James A DeCaprio, Paul F Lambert   +5 more
doaj   +1 more source

Merkel Cell Polyomavirus in Merkel Cell Carcinoma: Integration Sites and Involvement of the KMT2D Tumor Suppressor Gene

Viruses, 2020
Merkel cell carcinoma (MCC) is an uncommon, lethal cancer of the skin caused by either Merkel cell polyomavirus (MCPyV) or UV-linked mutations. MCPyV is found integrated into MCC tumor genomes, accompanied by truncation mutations that render the MCPyV ...
Reety Arora, Jae Eun Choi, Paul W. Harms, Pratik Chandrani   +3 more
doaj   +1 more source

Structures of Merkel cell polyomavirus VP1 complexes define a sialic acid binding site required for infection. [PDF]

PLoS Pathogens, 2012
The recently discovered human Merkel cell polyomavirus (MCPyV or MCV) causes the aggressive Merkel cell carcinoma (MCC) in the skin of immunocompromised individuals.
Ursula Neu, Holger Hengel, Bärbel S Blaum, Rachel M Schowalter, Dennis Macejak, Michel Gilbert, Warren W Wakarchuk, Akihiro Imamura, Hiromune Ando, Makoto Kiso, Niklas Arnberg, Robert L Garcea, Thomas Peters, Christopher B Buck, Thilo Stehle   +14 more
doaj   +1 more source

Cytokeratin and Neuroendocrine Positivity in Cutaneous Small Blue Round Cell Tumor-Is It Always Merkel Cell Carcinoma? [PDF]

J Cutan Pathol
ABSTRACT We present a case of a 39‐year‐old woman initially diagnosed with Merkel cell carcinoma (MCC), a highly aggressive neuroendocrine carcinoma, due to the presence of cytokeratin and neuroendocrine marker expression. The tumor was dermal based, showing small round blue cells with fine chromatin, scant cytoplasm, and scattered mitotic figures ...
Moubarak S, McAfee J, Fritchie K, Ko JS, Billings SD, Ronen S.   +5 more
europepmc   +2 more sources

Merkel Cell Polyomavirus DNA Detection in Respiratory Samples: Study of a Cohort of Patients Affected by Cystic Fibrosis

Viruses, 2019
Background: The role of Merkel cell polyomavirus (MCPyV) as a respiratory pathogen is controversial, and it is still unclear in patients with cystic fibrosis (CF).
Carla Prezioso, Federica Maria Di Lella, Donatella Maria Rodio, Camilla Bitossi, Maria Trancassini, Annamaria Mele, Corrado de Vito, Guido Antonelli, Valeria Pietropaolo   +8 more
doaj   +1 more source

Low prevalence of Merkel cell polyomavirus in human epithelial thymic tumors

Thoracic Cancer, 2019
Background The etiology of thymic epithelial tumors is unknown. Murine polyomavirus strain PTA has been shown to induce thymomas in mice. Recently, using diverse molecular techniques, we reported the presence of human polyomavirus 7 (HPyV7) in thymic ...
Emil Chteinberg, Faisal Klufah, Dorit Rennspiess, Mick F. Mannheims, Myrurgia A. Abdul‐Hamid, Mario Losen, Marlies Keijzers, Marc H. De Baets, Anna Kordelia Kurz, Axel zur Hausen   +9 more
doaj   +1 more source

Comparison of Quantitative Real-Time PCR and Digital PCR to Detect the Polyomavirus in Merkel Cell Carcinoma

Viruses, 2022
Merkel cell polyomavirus (MCPyV) prevalence in Merkel cell carcinoma (MCC) cases is controversial. The detection and quantification of MCPyV DNA is mainly performed by PCR techniques using formalin-fixed, paraffin-embedded (FFPE) tissues. The aim of this
Martina Barchitta, Andrea Maugeri, Elisabetta Campisi, Roberta Magnano San Lio, Giuliana Favara, Hector Jose Soto Parra, Lucia Salvatorelli, Gaetano Magro, Guido Basile, Antonella Agodi   +9 more
doaj   +1 more source

Detection of four human polyomaviruses (MCPyV, HPyV6, HPyV7 and TSPyV) in cervical specimens from HIV-infected and HIV-uninfected women: Table 1

Sexually Transmitted Infections, 2016
Pratt Kolia-Diafouka, Vincent Foulongne, Nathalie Boulle, Jean Ngou, Helen Kelly, Bernard Sawadogo, Sinéad Delany‐Moretlwe, Philippe Mayaud, Michel Segondy   +8 more
openalex   +3 more sources

Evidencing the presence of merkel cell polyomavirus in papillary thyroid cancer

Scientific Reports, 2021
Merkel cell polyomavirus (MCPyV) infects most people asymptomatically, but recent reports indicate that the virus may be related to carcinogenesis. This study aimed to evaluate the impact of MCPyV on the development of papillary thyroid cancer (PTC ...
Monir Ghanghareh, Jalal Mosayebi Amroabadi, Seyed Mohammad Tavangar, Shiva Irani, Fatemeh Sakhaee, Morteza Ghazanfari Jajin, Farzam Vaziri, Seyed Davar Siadat, Abolfazl Fateh   +8 more
doaj   +1 more source