Results 61 to 70 of about 3,352 (198)

Ultrastructural proof of polyomavirus in Merkel cell carcinoma tumour cells and its absence in small cell carcinoma of the lung. [PDF]

PLoS ONE, 2009
BACKGROUND: A new virus called the Merkel Cell Polyomavirus (MCPyV) has recently been found in Merkel Cell Carcinoma (MCC). MCC is a rare aggressive small cell neuroendocrine carcinoma primarily derived from the skin, morphologically indistinguishable ...
Charlotte T A H Wetzels, Jolanda G M Hoefnagel, Judith M J E Bakkers, Henry B P M Dijkman, Willeke A M Blokx, Willem J G Melchers   +5 more
doaj   +1 more source

Lymphotropism of Merkel Cell Polyomavirus Infection, Nova Scotia, Canada

Emerging Infectious Diseases, 2010
To test the hypothesis that Merkel cell polyomavirus (MCPyV) can infect cells of the lymphoid system, we analyzed 353 specimens, including 152 non-Hodgkin lymphomas, 44 Hodgkin lymphomas, 110 benign lymph nodes, 27 lymph nodes with metastasis, and 20 ...
Sonia Toracchio, Annette Foyle, Vojtech Sroller, Jon A. Reed, Jun Wu, Claudia A. Kozinetz, Janet S. Butel   +6 more
doaj   +1 more source

The significance of PAX5 in Merkel cell carcinoma. [PDF]

J Pathol
Abstract Merkel cell carcinoma (MCC) is a highly malignant skin cancer that expresses epithelial‐, neuroendocrine‐, and lymphoid‐associated genes. Here, we focused on B‐cell differentiation, which is characterised by the coexpression of PAX5 and TdT. PAX5 is the master regulator of B‐cell commitment and is expressed in 65% of MCC cases.
Chteinberg E, Kolarova J, Vogt J, Macamo A, Bormann F, Kretzmer H, Speel EJ, van den Oord J, Schneider C, Stilgenbauer S, Becker JC, Winnepenninckx V, Biessen E, Zenke M, Kurz AK, Siebert R, Zur Hausen A.   +16 more
europepmc   +2 more sources

Detection of Merkel Cell Polyomavirus in Seborrheic Keratosis

Frontiers in Microbiology, 2018
Seborrheic keratosis (SK) is the most common benign cutaneous neoplasm. A subset shows increased p16 expression. Since SK shares several features with verruca vulgaris, e.g., increased p16 expression, human papillomaviruses (HPV) have been suggested as ...
Lisa M. Hillen, Dorit Rennspiess, Ernst-Jan Speel, Anke M. Haugg, Véronique Winnepenninckx, Axel zur Hausen   +5 more
doaj   +1 more source

Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation. [PDF]

PLoS Pathogens, 2016
Merkel cell polyomavirus (MCPyV) is an etiological agent of Merkel cell carcinoma (MCC), a highly aggressive skin cancer. The MCPyV small tumor antigen (ST) is required for maintenance of MCC and can transform normal cells.
Christian Berrios, Megha Padi, Mark A Keibler, Donglim Esther Park, Vadim Molla, Jingwei Cheng, Soo Mi Lee, Gregory Stephanopoulos, John Quackenbush, James A DeCaprio   +9 more
doaj   +1 more source

Merkel Cell Polyomavirus (MCPyV) in the Context of Immunosuppression: Genetic Analysis of Noncoding Control Region (NCCR) Variability among a HIV-1-Positive Population

Viruses, 2020
Background: Since limited data are available about the prevalence of Merkel cell polyomavirus (MCPyV) and the genetic variability of its noncoding control region (NCCR) in the context of immunosuppression, this study aimed to investigate the distribution
C. Prezioso, F. Obregón, Donatella Ambroselli, Sara Petrolo, Paola Checconi, D. M. Rodio, L. Coppola, A. Nardi, C. Vito, L. Sarmati, M. Andreoni, A. Palamara, M. Ciotti, V. Pietropaolo   +13 more
semanticscholar   +1 more source

Two cases of Merkel cell carcinoma presenting Merkel cell polyomavirus (MCPyV) immunohistologically

Skin Cancer, 2013
Natsuko Tohgi, Hiroshi Takasu, Kensei Katsuoka, Natsuko Kounoike, Mitsuru Nemoto, Takashi Takeda   +5 more
openalex   +2 more sources

The presence of Merkel cell carcinoma polyomavirus is associated with a distinct phenotype in neoplastic Merkel cell carcinoma cells and their tissue microenvironment.

PLoS ONE, 2020
AimsMerkel cell carcinoma (MCC) is an aggressive primary neuroendocrine tumor of the skin, associated with Merkel cell polyomavirus (MCPyV) in 49-89% of cases, depending on the country of origin and the techniques of detection.
María-Dolores Mendoza, Carlos Santonja, Carmen Gonzalez-Vela, Angel Concha, Nicolás Iglesias Pena, Eva-Maria Andrés-Esteban, Jose Pedro Vaque, Laura Cereceda, Raquel Pajares, H Kutzner, Luis Requena, Miguel A Piris   +11 more
doaj   +1 more source

Evaluation of Merkel Cell Polyomavirus DNA in Tissue Samples from Italian Patients with Diagnosis of MCC

Viruses, 2021
Because the incidence of Merkel cell carcinoma (MCC) has increased significantly during the last 10 years and it is recognized that Merkel cell polyomavirus (MCPyV) and ultraviolet (UV) radiation represent two different etiological inputs sharing ...
Carla Prezioso, Raffaella Carletti, Francisco Obregon, Francesca Piacentini, Anna Maria Manicone, Giuseppe Soda, Ugo Moens, Cira Di Gioia, Valeria Pietropaolo   +8 more
doaj   +1 more source

Harnessing viral footprints in circulating free DNA (cfDNA) for early cancer detection: A focus on liquid‐biopsy‐based screening

International Journal of Cancer, Volume 158, Issue 3, Page 511-526, 1 February 2026.
Abstract Viral infections play a significant role in cancer development, making detecting viral signatures a promising approach for early cancer diagnosis. Circulating free DNA (cfDNA), released into the bloodstream by tumors and other cells, has emerged as a powerful biomarker for non‐invasive cancer screening.
Richard Donkor Amponsah, Emmanuel Addai Gyabaah, Moro Amidu, Zhao Cheng, Fazlur Rahman Talukdar   +4 more
wiley   +1 more source