Results 1 to 10 of about 3,779 (167)

An aptamer specifically targeting mCRP ameliorates experimental arthritis [PDF]

Journal of Orthopaedic Translation
Background: Recent evidence highlights the important role of the liver–bone axis in the development of arthritis, particularly rheumatoid arthritis (RA) and osteoarthritis (OA). The liver secretes various factors that impact joint health, one of which is
Zhuqian Wang, Duoli Xie, Peixi Zhu, Jianmin Guo, Chunhao Cao, Yu Du, Aiping Lu, Chao Liang   +7 more
doaj   +5 more sources

Circulating Levels of the Proinflammatory Monomeric Isoform of C-Reactive Protein (mCRP) Correlate with Intra-Tumoral mCRP Abundance in Stage II-III Colon Cancer Patients [PDF]

Journal of Inflammation Research
Anniken Jørlo Fuglestad,1– 3 Paula Anna Bousquet,1 Anne Helene Køstner,3 Sebastian Meltzer,1 Britta Kleist,4 Anne Hansen Ree,1,2 Ibraheem M Rajab,5 Lawrence A Potempa,6 Rafael Fernandez-Botran,7 Christian Kersten1,3 1Department of Oncology, Akershus ...
Fuglestad AJ, Bousquet PA, Køstner AH, Meltzer S, Kleist B, Ree AH, Rajab IM, Potempa LA, Fernandez-Botran R, Kersten C   +9 more
doaj   +4 more sources

mCRP as a Biomarker of Adult-Onset Still’s Disease: Quantification of mCRP by ELISA

Frontiers in Immunology, 2022
BackgroundC-reactive protein (CRP) is a dynamic protein that undergoes conformational changes between circulating native pentameric CRP (pCRP), pentameric symmetrical forms (pCRP*) and monomeric (or modified) CRP (mCRP) forms.
Chitose Fujita, Chitose Fujita, Yasuo Sakurai, Yasuo Sakurai, Yuki Yasuda, Rino Homma, Cheng-Long Huang, Cheng-Long Huang, Masaaki Fujita, Masaaki Fujita, Masaaki Fujita, Masaaki Fujita   +11 more
doaj   +4 more sources

The Role of Anti-mCRP Autoantibodies in Lupus Nephritis

Kidney Diseases, 2023
Background: Lupus nephritis is characterized by multiple autoantibodies production. However, there are few autoantibodies associated with disease activity and prognosis.
Mo Yuan, Ying Tan, Ming-hui Zhao
doaj   +4 more sources

mCRP-Associated Vascular Pathophysiology in Progression and Outcome of Intracerebral Hemorrhage. [PDF]

Int J Mol Sci
Monomeric C-reactive protein (mCRP), derived from the dissociation of the native pentameric CRP (pCRP), has been implicated in the pathophysiology of various neurological conditions, particularly intracerebral hemorrhage (ICH) and neurodegenerative ...
Șalari G, Slevin M.
europepmc   +3 more sources

The plasma level of mCRP is linked to cardiovascular disease in antineutrophil cytoplasmic antibody-associated vasculitis [PDF]

Arthritis Research & Therapy, 2020
Background C-reactive protein (CRP) has two natural isomers: C-reactive protein pentamer (pCRP) and C-reactive protein monomer (mCRP). The levels of CRP are significantly elevated in patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated ...
Kai-Li Wu, Qing-Hui Liang, Bin-Tao Huang, Na Ding, Bo-Wei Li, Jian Hao   +5 more
doaj   +4 more sources

Combination of anti-C1qA08 and anti-mCRP a.a.35-47 antibodies is associated with renal prognosis of patients with lupus nephritis

Frontiers in Immunology, 2023
ObjectiveThe aim of this study is to explore the prevalence and clinicopathological associations between anti-C1qA08 antibodies and anti-monomeric CRP (mCRP) a.a.35-47 antibodies and to explore the interaction between C1q and mCRP.MethodsNinety patients ...
Xiao-Ling Liu, Xiao-Ling Liu, Xiao-Ling Liu, Xiao-Ling Liu, Xiao-Ling Liu, Xiao-Ling Liu, Ying Tan, Ying Tan, Ying Tan, Ying Tan, Ying Tan, Feng Yu, Shang-Rong Ji, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao, Ming-Hui Zhao   +17 more
doaj   +4 more sources

The binding of monomeric C-reactive protein (mCRP) to Integrins αvβ3 and α4β1 is related to its pro-inflammatory action. [PDF]

PLoS ONE, 2014
The prototypic acute phase reactant C-reactive protein (CRP) is not only a marker but also a potential contributor to inflammatory diseases. CRP exists as the circulating native, pentameric CRP (pCRP) and the monomeric isoform (mCRP), formed as a result ...
Masaaki Fujita, Yoko K Takada, Yoshihiro Izumiya, Yoshikazu Takada   +3 more
doaj   +5 more sources

Higher monomeric C-reactive protein levels are associated with premature coronary artery disease [PDF]

Frontiers in Immunology
IntroductionChronic inflammation is a major risk factor for coronary artery disease (CAD). Currently, the inflammatory cardiovascular risk is assessed via C-reactive protein (CRP) levels measured using a high-sensitivity assay (hsCRP).
Ivan Melnikov, Ivan Melnikov, Sergey Kozlov, Sergey Okhota, Sergey Okhota, Olga Saburova, Yuliya Avtaeva, Tatiana Kuznetsova, Konstantin Guria, Lyudmila Prokofieva, Tatiana Riazantseva, Tatiana Riazantseva, Shang-Rong Ji, Yi Wu, Zufar Gabbasov   +14 more
doaj   +3 more sources

A conformational change of C-reactive protein drives neutrophil extracellular trap formation in inflammation [PDF]

BMC Biology
Background C-reactive protein (CRP) represents a routine diagnostic marker of inflammation. Dissociation of native pentameric CRP (pCRP) into the monomeric structure (mCRP) liberates proinflammatory features, presumably contributing to excessive immune ...
Ebru Karasu, Rebecca Halbgebauer, Lena Schütte, Johannes Greven, Felix M. Bläsius, Johannes Zeller, Oscar Winninger, David Braig, David Alexander Christian Messerer, Bettina Berger, Hendrik Feuerstein, Anke Schultze, Karlheinz Peter, Uwe Knippschild, Klemens Horst, Frank Hildebrand, Steffen U. Eisenhardt, Markus Huber-Lang   +17 more
doaj   +3 more sources