Results 21 to 30 of about 3,779 (167)

C-reactive protein conformations and their association with the IL-1β/IL-6 pathway in ocular inflammatory conditions [PDF]

Frontiers in Immunology
IntroductionC-reactive protein (CRP) plays a critical role in the innate immune system and serves as a biomarker for various inflammatory conditions. CRP is a dynamic protein undergoing conformational changes between pentameric (pCRP) and monomeric (mCRP)
Mercedes S. Nabaes Jodar, Víctor Llorenç, Víctor Llorenç, Marc Figueras-Roca, Marc Figueras-Roca, Maite Sainz de-la-Maza, Maite Sainz de-la-Maza, Alfredo Adán, Alfredo Adán, Blanca Molins   +9 more
doaj   +2 more sources

Monomeric C reactive protein (mCRP) regulates inflammatory responses in human and mouse chondrocytes [PDF]

Laboratory Investigation, 2021
C-reactive protein (CRP) is an acute-phase protein that is used as an established biomarker to follow disease severity and progression in a plethora of inflammatory diseases. However, its pathophysiologic mechanisms of action are still poorly defined and remain elusive. CRP, in its pentameric form, exhibits weak anti-inflammatory activity.
C. Ruiz-Fernández, M. González-Rodríguez, V. Francisco, Ibraheem Rajab, R. Gómez, J. Conde, F. Lago, J. Pino, A. Mobasheri, M. González-Gay, A. Mera, L. Potempa, O. Gualillo   +12 more
semanticscholar   +4 more sources

C-reactive protein: the nexus between inflammation and protein misfolding diseases. [PDF]

Front Immunol
C-reactive protein (CRP), an acute-phase protein primarily produced by hepatocytes in response to pro-inflammatory cytokines, is a widely used clinical marker for inflammation and tissue damage. In its native state, CRP exists in a stable pentameric form
Roy A, Zeller J, Nero TL, Klepetko J, Eisenhardt SU, Parker MW, McFadyen JD, Peter K.   +7 more
europepmc   +2 more sources

Redefining CRP in tissue injury and repair: more than an acute pro-inflammatory mediator. [PDF]

Front Immunol
Most early studies investigating the role of C-reactive protein (CRP) in tissue damage determined it supported pro-hemostatic and pro-inflammatory activities.
Potempa M, Hart PC, Rajab IM, Potempa LA.   +3 more
europepmc   +2 more sources

Resveratrol Activates Antioxidant Protective Mechanisms in Cellular Models of Alzheimer’s Disease Inflammation

Antioxidants
Resveratrol is a natural phenolic compound with known benefits against neurodegeneration. We analyzed in vitro the protective mechanisms of resveratrol against the proinflammatory monomeric C-reactive protein (mCRP).
Clara Bartra, Yi Yuan, Kristijan Vuraić, Haydeé Valdés-Quiroz, Pau Garcia-Baucells, Mark Slevin, Ylenia Pastorello, Cristina Suñol, Coral Sanfeliu   +8 more
doaj   +2 more sources

Role of C-Reactive Protein at Sites of Inflammation and Infection

Frontiers in Immunology, 2018
C-reactive protein (CRP) is an acute inflammatory protein that increases up to 1,000-fold at sites of infection or inflammation. CRP is produced as a homopentameric protein, termed native CRP (nCRP), which can irreversibly dissociate at sites of ...
Nicola R. Sproston, Jason J. Ashworth
doaj   +2 more sources

C-reactive protein induced T cell activation is an indirect monocyte-dependent mechanism involving the CD80/CD28 pathway [PDF]

Frontiers in Immunology
IntroductionT cells are major components of the immune system. Their activation requires interaction between the T cell receptor and co-stimulatory molecules, crucial during infection, inflammation, and allogeneic rejection.
Julia Thomé, Julia Limmer, Julia Limmer, Teresa Z. Brose, Johannes Zeller, Nina Chevalier, Nina Chevalier, Anna-Lena Schäfer, Laura Schneider, Maike Lind, Thierry Christmann, Marie Dreck, Sheena Kreuzaler, David Braig, Karlheinz Peter, Franziska Pankratz, Steffen U. Eisenhardt   +16 more
doaj   +2 more sources

TEO-MCRP: Thermal exchange optimization-based clustering routing protocol with a mobile sink for wireless sensor networks

Journal of King Saud University - Computer and Information Sciences, 2022
Sensor nodes consume their energy quickly due to their continuous perception, routing, and internal circuit mechanisms in Wireless Sensor Networks (WSNs). Especially, the nodes that are close to the sink node consume their energy more quickly, causing the hot spot problem.
S. Yalçın, E. Erdem
semanticscholar   +3 more sources

mCRP triggers angiogenesis by inducing F3 transcription and TF signalling in microvascular endothelial cells [PDF]

Thrombosis and Haemostasis, 2016
SummaryInflammation contributes to vascular disease progression. However, the role of circulating inflammatory molecules on microvascular endothelial cell (mECs) is not fully elucidated. The aim of this study was to investigate the effects of the short pentraxin CRP on microvascular endothelial cell angiogenic function.
E. Peña, R. L. La Torre, G. Arderiu, M. Slevin, L. Badimón   +4 more
semanticscholar   +6 more sources

Fueling the flames of colon cancer – does CRP play a direct pro-inflammatory role?

Frontiers in Immunology, 2023
BackgroundSystemic inflammation, diagnostically ascribed by measuring serum levels of the acute phase reactant C-reactive protein (CRP), has consistently been correlated with poor outcomes across cancer types.
Anne Helene Køstner, Anne Helene Køstner, Anniken Jørlo Fuglestad, Anniken Jørlo Fuglestad, Jeanette Baehr Georgsen, Patricia Switten Nielsen, Patricia Switten Nielsen, Kristina Bang Christensen, Helle Zibrandtsen, Erik Thorlund Parner, Ibraheem M. Rajab, Lawrence A. Potempa, Torben Steiniche, Christian Kersten, Christian Kersten   +14 more
doaj   +1 more source