Results 71 to 80 of about 33,185 (190)

DNA Nanostructure‐Templated Multivalency Enables Broad‐Spectrum Virus Inhibition

Advanced Science, Volume 13, Issue 14, 9 March 2026.
A honeycomb‐shaped DNA nanostructure is introduced that organizes nanobodies or aptamers into trimeric clusters mirroring the native hemagglutinin arrangement on influenza viruses. This geometry‐matched multivalency enhances binding avidity by up to 1000‐fold, resulting in robust, broad‐spectrum viral neutralization and a 30–55% improvement in host ...
Saurabh Umrao, Abhisek Dwivedy, Dhanush Gandavadi, Chi Chen, Lifeng Zhou, Jinwei Duan, Vineetha Mareddy, Ying Fang, Xing Wang   +8 more
wiley   +1 more source

Tocotrienols: A Review From Source to Therapeutic Applications

Food Frontiers, Volume 7, Issue 2, March 2026.
Tocotrienols demonstrate superior antioxidant, neuroprotective, and anti‐inflammatory properties compared to conventional vitamin E forms, with promising therapeutic applications across multiple disorders when delivered through optimized systems that enhance their inherently limited bioavailability.
Natalia‐Carolina Londoño, Nidia Casas‐Forero, Andres‐Felipe Garzón‐Méndez, Dalí‐Aleixandra Rojas‐Díaz, Mary‐Luz Olivares‐Tenorio, Hernan‐Mauricio Romero, Jesús‐Alberto García‐Núñez   +6 more
wiley   +1 more source

CDC42‐Effector Proteins Regulate Higher Order Structure of Septins Required for CNS Myelin Integrity

Glia, Volume 74, Issue 3, March 2026.
CDC42‐effector proteins 1/2 are present in CNS myelin. They facilitate the higher order structure of myelin septin filaments. Their loss impairs septin‐dependent scaffolding of myelin. Myelin outfoldings do not cause secondary neuropathology per se. ABSTRACT The regular structure of CNS myelin requires specialized structural proteins, including septin ...
Sophie Hümmert, Joana Paes de Faria, Olaf Jahn, Ege Bilgin, Nikola Łukasik, Chethana Rao, Mišo Mitkovski, Fritz Benseler, Nils Brose, Sophie B. Siems, Sandra Goebbels, Wiebke Möbius, Helge Ewers, João B. Relvas, Hauke B. Werner   +14 more
wiley   +1 more source

Pyrazoline Derivatives: Synthesis, In Silico, Enzyme Kinetics Studies and Biological Activity against Cholinesterase, Lipoxygenase, and α‐Amylase

ChemistrySelect, Volume 11, Issue 9, 5 March 2026.
ABSTRACT Nucleophilic cyclization of the α, β‐unsaturated carbonyl framework of the prepared (E)‐4‐(3‐bromo‐4‐hydroxy‐5‐methoxyphenyl)but‐3‐en‐2‐one with various hydrazine derivatives to afford their corresponding pyrazolines has been achieved. The enzyme assays conducted showed significant α‐amylase inhibitory activity for 4b with IC50 value of 2.7 µM.
Redolf S. Segodi, E. N. Agbo, Leoma B. Mofeli, K. W. Poopedi, O. O. Oderinlo, W. Nxumalo   +5 more
wiley   +1 more source

Therapeutic Efficacy of the Supersulfide Donor NAC‐S2 in Influenza Virus Pneumonia via Suppression of Excessive Inflammatory Responses

Microbiology and Immunology, Volume 70, Issue 3, Page 148-159, March 2026.
ABSTRACT Influenza pneumonia is characterized by excessive inflammatory responses that contribute to severe lung injury and mortality. Supersulfides, endogenously produced cysteine‐derived persulfides and polysulfides, exert potent antioxidant, anti‐ferroptotic, and anti‐inflammatory activities; however, their therapeutic potential after disease onset ...
Foysal Hossen, Takahisa Kouwaki, Yukio Fujiwara, Hiroyasu Tsutsuki, Tianli Zhang, Chunyu Guo, Azizur Rahman, Yoshihiro Komohara, Hiroyuki Oshiumi, Tomohiro Sawa   +9 more
wiley   +1 more source

Cytotoxicity of Southeast Asian snake venoms

Journal of Venomous Animals and Toxins including Tropical Diseases, 2012
Cytotoxicity of venoms from eleven medically important snakes found in Southeast Asia (Naja kaouthia, Naja siamensis, Naja sumatrana, Ophiophagus hannah, Bungarus candidus, Bungarus fasciatus, Enhydrina schistosa, Calloselasma rhodostoma, Trimeresurus ...
A Jamunaa, J Vejayan, I Halijah, SH Sharifah, S Ambu   +4 more
doaj   +1 more source

A Monoclonal Antibody ELISA–Based Assay for Measuring the Potency of Candidate H5 Clade 2.3.4.4b Pandemic Influenza Vaccines

Influenza and Other Respiratory Viruses, Volume 20, Issue 3, March 2026.
ABSTRACT Background The single radial immunodiffusion (SRID) assay is used to determine the potency of inactivated influenza vaccines. Nevertheless, development of alternative influenza vaccine potency assays with greater sensitivity and less reliance on large quantities of reference reagents is needed.
Marcus Odin, Falko Schmeisser, Jackeline Soto, Jerry P. Weir   +3 more
wiley   +1 more source

Pathogenesis and phylogenetic analyses of canine distemper virus strain ZJ7 isolate from domestic dogs in China

Virology Journal, 2011
A new isolate of canine distemper virus (CDV), named ZJ7, was isolated from lung tissues of a dog suspected with CDV infection using MDCK cells. The ZJ7 isolate induced cytopathogenic effects of syncytia in MDCK cell after six passages.
Tan Bin, Wen Yong-Jun, Wang Feng-Xue, Zhang Shu-Qin, Wang Xiu-Dong, Hu Jia-Xin, Shi Xin-Chuan, Yang Bo-Chao, Chen Li-Zhi, Cheng Shi-Peng, Wu Hua   +10 more
doaj   +1 more source

Strain Agnostic Influenza Virus Propagation in a Serum‐Free, Suspension‐Adapted MDCK Cell Line

Influenza and Other Respiratory Viruses, Volume 20, Issue 3, March 2026.
ABSTRACT Background The continuing circulation and evolution of seasonal influenza viruses remains a public health and socioeconomic threat on a global scale. Viral surveillance and vaccination of the public have been relied upon to confer and boost immunity in the population. Traditionally, influenza strains are propagated in embryonated chicken eggs,
Jessica B. Huskey, Michelle L. Rock, Pooja V. Chaudhary, Emily C. Hill, Madeline E. Hoover, Nicole M. Rideout, Kamerin D. Dean, Thomas Scott Alderman, Phong Ho, M. Anthony Moody, Gregory D. Sempowski, Thomas H. Oguin III   +11 more
wiley   +1 more source

Exploration of the protective mechanisms of Icariin against cisplatin-induced renal cell damage in canines

Frontiers in Veterinary Science
This study delves into the protective mechanisms of Icariin (ICA) against cisplatin-induced damage in Madin-Darby canine kidney (MDCK) cells. Comprising two distinct phases, the investigation initially employed a single-factor randomized design to ...
Jiayi Liu, Liuwei Xie, He Zhai, Dongwei Wang, Xiao Li, Yao Wang, Mingqiang Song, Chao Xu   +7 more
doaj   +1 more source