IIIG9 and PP1α form a protein complex in the adherens junctions of polarized ependymal and MDCK cells [PDF]
Fluids and Barriers of the CNSBackground IIIG9 was originally identified as a novel regulatory subunit of protein phosphatase 1 (PP1, PPP1R32) in ependymal cells, where it localizes to cilia and adherens junctions.
María José Oviedo +8 more
doaj +2 more sources
Caveolin-1 and -2 in the Exocytic Pathway of MDCK Cells [PDF]
The Journal of Cell Biology, 1998 . We have studied the biosynthesis and transport of the endogenous caveolins in MDCK cells. We show that in addition to homooligomers of caveolin-1, heterooligomeric complexes of caveolin-1 and -2 are formed in the ER.
P. Scheiffele +5 more
semanticscholar +4 more sources
Selective inhibition of transcytosis by brefeldin A in MDCK cells.
Cell, 1991 Treatment of most cells with brefeldin A (BFA) leads to the retrieval of the Golgi complex to the endoplasmic reticulum, presumably reflecting an inhibition of cytoplasmic coat protein binding to Golgi membranes. Although BFA has been thought to act only
W. Hunziker, J. Whitney, I. Mellman
semanticscholar +3 more sources
Claudin-4 knockout by TALEN-mediated gene targeting in MDCK cells: Claudin-4 is dispensable for the permeability properties of tight junctions in wild-type MDCK cells. [PDF]
PLoS ONE, 2017 Epithelia act as a barrier between the internal and external environments, and the movement of substances via the paracellular pathway is regulated by tight junctions (TJs). Claudins are major determinants of TJ permeability.
Shinsaku Tokuda +2 more
doaj +2 more sources
Transcriptomic Characterization Reveals Attributes of High Influenza Virus Productivity in MDCK Cells. [PDF]
Viruses, 2021 Ye Q +6 more
europepmc +2 more sources
IRF7-deficient MDCK cell based on CRISPR/Cas9 technology for enhancing influenza virus replication and improving vaccine production [PDF]
PeerJ, 2022 The influenza virus is a cause of seasonal epidemic disease and enormous economic injury. The best way to control influenza outbreaks is through vaccination.
Oraphan Mayuramart +8 more
doaj +2 more sources
Viruses, 2021 Madin–Darby canine kidney (MDCK) cells are commonly used for the isolation of mammalian influenza A viruses. The goal of this study was to compare the sensitivity and suitability of the original MDCK cell line in comparison with MDCK-derived cell lines ...
Matthew Suderman +6 more
doaj +1 more source
Metabolites, 2023 Renal failure is a common chronic disease in dogs that substantially affects both their quality of life and longevity. The objective of this study was to assess the protective mechanisms of baicalin in cisplatin-induced Madin–Darby canine kidney (MDCK ...
Yao Wang +4 more
doaj +1 more source
Stable Ectopic Expression of ST6GALNAC5 Induces Autocrine MET Activation and Anchorage-Independence in MDCK Cells. [PDF]
PLoS ONE, 2016 The epithelial-mesenchymal transition (EMT) is a complex cancer progression that can boost the metastatic potential of transformed cells by inducing migration, loss of cell adhesion, and promoting proliferation under anchorage-independent conditions.
Chia Chu +3 more
doaj +1 more source
Cell Volume Fluctuations in MDCK Monolayers [PDF]
Biophysical Journal, 2015 Cells moving collectively in tissues constitute a form of active matter, in which collective motion depends strongly on driven fluctuations at the single-cell scale. Fluctuations in cell area and number density are often seen in monolayers, yet their role in collective migration is not known.
Steven M., Zehnder +4 more
openaire +3 more sources