Clostridium perfringensepsilon toxin H149A mutant as a platform for receptor binding studies [PDF]
, 2013 Clostridium perfringens epsilon toxin (Etx) is a pore-forming toxin responsible for a severe and rapidly fatal enterotoxemia of ruminants. The toxin is classified as a category B bioterrorism agent by the U.S.
Abe +40 more
core +1 more source
Alpha1-Antitrypsin Attenuates Renal Fibrosis by Inhibiting TGF-β1-Induced Epithelial Mesenchymal Transition. [PDF]
PLoS ONE, 2016 Alpha1-antitrypsin (AAT) exerts its anti-inflammatory effect through regulating the activity of serine proteinases. This study evaluated the inhibitory effects of AAT against the transforming growth factor (TGF)-β1 induced epithelial-to-mesenchymal ...
Jang-Hee Cho +10 more
doaj +1 more source
Scatter factor : molecular characteristics and effect on the invasiveness of epithelial cells [PDF]
, 1990 The generation of invasiveness in transformed cells represents an essential step of tumor progression. We have previously shown that MDCK epithelial cells, which are deprived of intracellular adhesion by the addition of anti-Arc-1/uvomorulin antibodies ...
Behrens, Jürgen +3 more
core +2 more sources
Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. [PDF]
, 2016 Mechanical force and Wnt signaling activate β-catenin-mediated transcription to promote proliferation and tissue expansion. However, it is unknown whether mechanical force and Wnt signaling act independently or synergize to activate β-catenin signaling ...
Benham-Pyle, Blair W +4 more
core +2 more sources
APOPTOSIS STUDY OF INDONESIAN AVIAN INFLUENZA VIRUS SUBTYPE H5N1 IN MADIN-DARBY CANINE KIDNEY CELLS
Jurnal Kedokteran Hewan, 2017 This study aimed to determine the ability of highly pathogenic avian influenza virus (HPAI) virus subtype H5N1 originated from Indonesia to induce apoptosis in Madin-Darby Canine Kidney (MDCK) cells.
NLP Indi Dharmayanti +3 more
doaj +1 more source
Evidence for a prepore stage in the action of Clostridium perfringens epsilon toxin. [PDF]
PLoS ONE, 2011 Clostridium perfringens epsilon toxin (ETX) rapidly kills MDCK II cells at 37°C, but not 4°C. The current study shows that, in MDCK II cells, ETX binds and forms an oligomeric complex equally well at 37°C and 4°C but only forms a pore at 37°C.
Susan L Robertson +3 more
doaj +1 more source
Collective and single cell behavior in epithelial contact inhibition [PDF]
, 2011 Control of cell proliferation is a fundamental aspect of tissue physiology central to morphogenesis, wound healing and cancer. Although many of the molecular genetic factors are now known, the system level regulation of growth is still poorly understood.
A. Puliafito +42 more
core +4 more sources
Scientific Reports, 2017 Src-family kinases, expressed in a wide variety of cell types, are anchored to cellular membranes through posttranslational lipid modifications and involved in diverse cellular signalling.
Takao Morinaga +4 more
doaj +1 more source
Effect of human activated NRAS on replication of delNS1 H5N1 influenza virus in MDCK cells
Virology Journal, 2011 Background RAS, coded by ras proto-oncogenes, played an important role in signal transmission to regulate cell growth and differentiation. Host activation of RAS was significant for IFN-sensitive vaccinia virus (delE3L) or attenuate influenza virus in ...
Zou Wei +3 more
doaj +1 more source
Clonal Stabilization Reveals a DAO/3MST-Expressing MDCK Subpopulation With Robust d-Cysteine-Mediated H<sub>2</sub>S Production. [PDF]
FASEB JA subpopulation of MDCK (NBL‐2) cells, an epithelial cell line derived from the normal kidney, expresses DAO and 3MST. The DAO/3MST‐expressing cells are progressively eliminated during passaging; however, clonal isolation enables the establishment of sublines that maintain stable H2S production. Clonal cells co‐expressing DAO and 3MST therefore provide
Miyamoto A +4 more
europepmc +2 more sources