Results 51 to 60 of about 57,512 (227)

A reassortant H9N2 influenza virus containing 2009 pandemic H1N1 internal-protein genes acquired enhanced pig-to-pig transmission after serial passages in swine [PDF]

, 2017
Avian H9N2 and 2009 pandemic H1N1 (pH1N1) influenza viruses can infect pigs and humans, raising the concern that H9N2: pH1N1 reassortant viruses could emerge.
Ma, Wenjun, Mancera Gracia, José Carlos, Richt, Juergen A, Saelens, Xavier, Van den Hoecke, Silvie, Van Reeth, Kristien   +5 more
core   +2 more sources

Programmable DNA‐Peptide Hybrid Nanostructures for Potent Neutralization of Multiple Influenza a Virus Subtypes

Advanced Functional Materials, EarlyView.
A multivalent antiviral platform based on honeycomb‐shaped DNA nanostructures (HC–Urumin) is developed to enhance the potency and breadth of the host defense peptide Urumin. Through spatially patterned trimeric presentation, HC–Urumin disrupts influenza A virus entry, improves cell viability, and reduces disease severity in vivo‐offering a modular and ...
Saurabh Umrao, Abhisek Dwivedy, Payton L. Haak, Dhanush Gandavadi, Laurie A. Rund, Chi Chen, Vineetha Mareddy, Lifeng Zhou, Jinwei Duan, Ying Fang, Andrew J. Steelman, Xing Wang   +11 more
wiley   +1 more source

The polarized expression of Na+,K+-ATPase in epithelia depends on the association between beta-subunits located in neighboring cells [PDF]

, 2005
The polarized distribution of Na+,K+-ATPase plays a paramount physiological role, because either directly or through coupling with co- and countertransporters, it is responsible for the net movement of, for example, glucose, amino acids, Ca2+, K+, Cl ...
Balda, MS, Cereijido, M, Contreras, RG, Lazaro, A, Matter, K, Moreno, J, Roldan, ML, Shoshani, L   +7 more
core  

Collective motion of cells crawling on a substrate: roles of cell shape and contact inhibition [PDF]

, 2016
Contact inhibition plays a crucial role in the motility of cells, the process of wound healing, and the formation of tumors. By mimicking the mechanical motion of calls crawling on a substrate using a pseudopod, we constructed a minimal model for ...
Molina, John Jairo, Schnyder, Simon Kaspar, Tanaka, Yuki, Yamamoto, Ryoichi   +3 more
core   +2 more sources

Bio‐Orthogonally Crosslinked Supramolecular Polymer Bottlebrush Hydrogels for Long‐Term 3D Cell Culture

Advanced Functional Materials, EarlyView.
Fibrous benzenetrispeptide (BTP) hydrogels, fabricated via strain‐promoted azide‐alkyne cycloaddition (SPAAC) crosslinking, form robust, bioinert networks. These hydrogels can support 3D cell culture, where cell viability and colony growth depend on the fiber content.
Ceren C. Pihlamagi, David Pretzel, Peer Nölte, Kourosh Rezaei, Ulrich S. Schubert, Johannes C. Brendel   +5 more
wiley   +1 more source

Cryotomography of budding influenza a virus reveals filaments with diverse morphologies that mostly do not bear a genome at their distal end [PDF]

, 2013
Influenza viruses exhibit striking variations in particle morphology between strains. Clinical isolates of influenza A virus have been shown to produce long filamentous particles while laboratory-adapted strains are predominantly spherical.
A Ali, A Harris, A Moeller, A Smirnov Yu, BE Eddy, BJ Chen, C Loney, C Scholtissek, CJ Elleman, CM Chu, Colin Loney, D McGeoch, David Bhella, David Jackson, DN Mastronarde, E Fournier, Frazer J. Rixon, GL Ada, I Archetti, JR Gog, JR Kremer, JS Rossman, JS Rossman, KB Renegar, L Hoyle, L Liljeroos, LJ Calder, LM Burleigh, M Adrian, P Palese, PC Roberts, PC Roberts, Peter Palese, R Arranz, RA Lamb, RA Lamb, RW Compans, RW Ruigrok, Swetha Vijayakrishnan, T Noda, T Noda, TA Bharat, V Doceul, Worawit Suphamungmee, Y Fujii, Y Geng   +45 more
core   +3 more sources

Nano‐ and Micro‐Sized Solid Materials Used as Antiviral Agents

Advanced Functional Materials, EarlyView.
Due to the rise of viral infections in humans and possible viral outbreaks, the use of nano‐ or micro‐sized materials as antiviral agents is rapidly increasing. This review explores their antiviral properties against RNA and DNA viruses, either as a prevention or a treatment tool, by delving into their mechanisms of action and how to properly assess ...
Orfeas‐Evangelos Plastiras, Imelda Raczkiewicz, Peggy Bouquet, Jean‐Philippe Dacquin, Jeremy Dhainaut, Anne Goffard, Christophe Volkringer   +6 more
wiley   +1 more source

Evaluation of near infrared dyes as markers of P-glycoprotein activity in tumors

Frontiers in Pharmacology, 2016
Aim: The multidrug resistance protein 1 (MDR1; P-glycoprotein) has been associated with efflux of chemotherapeutic agents from tumor cells and poor patient prognosis.
Inessa Semenenko, Emma Portnoy, Mohammed AbouKaoud, Serge Guzy, Serge Guzy, Miri Shmuel, Gal Itzhak, Sara Eyal   +7 more
doaj   +1 more source

Establishment and Validation of a New Co-Culture for the Evaluation of the Permeability through the Blood–Brain Barrier in Patients with Glioblastoma

Pharmaceutics, 2023
Currently, the mechanisms involved in drug access to the central nervous system (CNS) are not completely elucidated, and research efforts to understand the behaviour of the therapeutic agents to access the blood–brain barrier continue with the utmost ...
Bárbara Sánchez-Dengra, Elena García-Montoya, Isabel González-Álvarez, Marival Bermejo, Marta González-Álvarez   +4 more
doaj   +1 more source

Afadin orients cell division to position the tubule lumen in developing renal tubules [PDF]

, 2017
In many types of tubules, continuity of the lumen is paramount to tubular function, yet how tubules generate lumen continuity in vivo is not known. We recently found the F-actin binding protein Afadin is required for lumen continuity in developing renal ...
Brakeman, Paul R., Bryant, David M., Gao, Lei, Hiremath, Chitkale, Long, Blake, Luby-Phelps, Katherine, Marciano, Denise K., Mostov, Keith E., Yang, Zhufeng, Zimmerman, Susan E.   +9 more
core   +2 more sources