Results 1 to 10 of about 1,892 (112)

Targeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins

Frontiers in Oncology, 2022
IFN-γ is a pleiotropic cytokine with immunomodulatory and tumoricidal functions. It has been used as an anti-tumor agent in adjuvant therapies for various cancers.
Luyu Zheng, Qun Liu, Rui-Yang Li, Shibin Chen, Jingyu Tan, Lina Li, Xichen Dong, Chang-zhi Huang, Tao Wen, Jian Liu   +9 more
semanticscholar   +3 more sources

Combined Usage of MDK Inhibitor Augments Interferon-γ Anti-Tumor Activity in the SKOV3 Human Ovarian Cancer Cell Line

Biomedicines, 2022
Ovarian cancer (OC) is a particularly lethal disease due to intratumoral heterogeneity, resistance to traditional chemotherapy, and poor response to targeted therapy and immunotherapy.
Qun Liu, Jingyu Tan, Zhenguo Zhao, Rui-Yang Li, Lu-Jun Zheng, Xiangyu Chen, Lina Li, Xichen Dong, Tao Wen, Jian Liu   +9 more
semanticscholar   +3 more sources

Autocrine and paracrine effects of MDK promote lymph node metastasis of cervical squamous cell carcinoma

iScience
Summary: Lymph node metastasis (LNM) is the main metastatic pathway of cervical cancer, which is closely related to 5-year survival rate of cervical squamous cell carcinoma (CSCC), yet the underlying mechanism remains unconfirmed.
He Fei, Tong Chen, Hua Jiang
semanticscholar   +3 more sources

Integrative single-cell and spatial transcriptomics analysis reveals MDK-NCL pathway’s role in shaping the immunosuppressive environment of lung adenocarcinoma

Frontiers in Immunology
Objectives The tumor microenvironment (TME) plays a critical role in the progression of lung adenocarcinoma (LUAD). This study aims to investigate the cellular composition of the TME in LUAD and assess the role of the MDK-NCL signaling pathway.
Yu Fu, Song Li, Yikang Zhao, Xiran Zhang, Xiaolu Mao, Ran Xu   +5 more
semanticscholar   +3 more sources

MDK promotes M2 macrophage polarization to remodel the tumour microenvironment in clear cell renal cell carcinoma

Scientific Reports
The efficacy of immunotherapy for clear cell renal cell carcinoma (ccRCC), especially advanced ccRCC, is limited, presenting a clinical challenge. This limitation is closely tied to the immune regulation network.
Naipeng Shi, Saisai Chen, Dong Wang, Tiange Wu, Nieke Zhang, Ming Chen, Xuefei Ding   +6 more
semanticscholar   +2 more sources

Midkine (MDK) in Hepatocellular Carcinoma: More than a Biomarker

Cells
Midkine (MDK) is a multifunctional secreted protein that can act as a cytokine or growth factor regulating multiple signaling pathways and being implicated in fundamental cellular processes, such as survival, proliferation, and migration.
Christiana Christou, A. Stylianou, V. Gkretsi   +2 more
semanticscholar   +3 more sources

Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma

Clinical and Translational Medicine
Background Temozolomide (TMZ), which is an alkylating agent, is the standard chemotherapeutic drug used for glioma treatment. However, the development of resistance to TMZ limits its efficacy.
Xiaonan Xi, Xiao-Jing Ding, Qianqian Wang, Ning Liu, Bangmao Wang, Genbei Wang, Weilong Zhong, Yaxin Lu   +7 more
semanticscholar   +2 more sources

Midkine (MDK) in cancer and drug resistance: from inflammation to therapy

Discover Oncology
Midkine (MDK) is a heparin-binding growth factor implicated in the pathogenesis of various diseases, including cancer, chronic inflammation, and multidrug resistance (MDR).
Berna Yıldırım, Kudret Kulak, Ayhan Bilir   +2 more
semanticscholar   +2 more sources

A novel pH-sensitive nanoparticles encapsulating anti-PD-1 antibody and MDK-siRNA overcome immune checkpoint blockade resistance in HCC via reshaping immunosuppressive TME

Journal of Experimental & Clinical Cancer Research
Immunotherapy, notably the immune checkpoint blockade (ICB), has demonstrated significant promise in the management of diverse neoplasms. However, the PD-1 inhibitor has exhibited suboptimal objective response rates and did not achieve the primary ...
Hai Xu, Shuo Li, Yifan Liu, Yoon-Young Sung, Yong Zhou, Huikun Wu   +5 more
semanticscholar   +2 more sources

Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis

Advanced Science
Elevated blood glucose levels may serve as an early indicator of underlying pancreatic cancer. Discriminating between pancreatic cancer‐associated new‐onset diabetes (PCAND) and new‐onset type 2 diabetes mellitus (T2DM) holds promise for enabling an ...
Zengyu Feng, Jianyao Lou, Chuanshuai Lin, Haocheng Yu, Yuheng Tu, Jiali Gong, Xiawei Li, Yulian Wu   +7 more
semanticscholar   +2 more sources