Targeting MDK alleviates bone loss via dual regulation of osteogenic differentiation and inflammatory cytokine expression [PDF]
Genes and DiseasesGrowth factors are bioactive molecules that play crucial roles in regulating growth, development, and disease processes, both locally and systemically.
Xieyidai Ruze +11 more
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Combined Usage of MDK Inhibitor Augments Interferon-γ Anti-Tumor Activity in the SKOV3 Human Ovarian Cancer Cell Line [PDF]
Biomedicines, 2022 Ovarian cancer (OC) is a particularly lethal disease due to intratumoral heterogeneity, resistance to traditional chemotherapy, and poor response to targeted therapy and immunotherapy.
Qun Liu +9 more
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Klinische Monatsblätter für Augenheilkunde, 2013 Arbeitsunfahigkeit, Klinikabrechnung oder Pflegestufe – das alles und noch viel mehr begutachtet der Medizinische Dienst der Krankenversicherung (MDK). Dafur verlangt er auch Unterlagen von Arzten. Doch welche Informationen muss man herausgeben und wie lauft eine Prufung ab?
Daniela Erhard
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Inhibition of the growth factor MDK/midkine by a novel small molecule compound to treat non-small cell lung cancer. [PDF]
PLoS ONE, 2013 Midkine (MDK) is a heparin-binding growth factor that is highly expressed in many malignant tumors, including lung cancers. MDK activates the PI3K pathway and induces anti-apoptotic activity, in turn enhancing the survival of tumors.
Huifang Hao +17 more
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Targeting MDK Abrogates IFN-γ-Elicited Metastasis inCancers of Various Origins
Frontiers in Oncology, 2022 IFN-γ is a pleiotropic cytokine with immunomodulatory and tumoricidal functions. It has been used as an anti-tumor agent in adjuvant therapies for various cancers.
Luyu Zheng +10 more
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Dissecting the molecular mechanisms of T cell infiltration in psoriatic lesions via cell-cell communication and regulatory network analysis [PDF]
Open Life SciencesThis study aims to elucidate the intercellular communication mechanisms underlying T cell infiltration in psoriatic skin. Single-cell RNA sequencing revealed increased proportions of endothelial cells and T cells, alongside a reduction in melanocytes in ...
Li Kexin +5 more
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Coordinated changes in midkine expression and midkine-associated multiomic profile in glioma microenvironment [PDF]
Scientific ReportsMidkine (MDK), a multifunctional growth factor, has been implicated in promoting tumor progression, yet its role in glioblastoma (GBM) remains insufficiently characterized. To investigate MDK’s function in glioma, we integrated four RNA-Seq datasets into
Mieszko Lachota +5 more
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Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury [PDF]
Advanced ScienceAcute kidney injury (AKI) is associated with a high prevalence of cognitive impairment, the underlying mechanisms remain elusive. This study explores the role of midkine (MDK), upregulated in renal injury, in mediating cognitive dysfunction following ...
Li Lu +10 more
doaj +2 more sources
Midkine Expression as a Candidate Biomarker to Predict the Recurrence of Stage IA Lung Adenocarcinoma [PDF]
JTO Clinical and Research ReportsBackground: Early recurrence limits the long-term survival of postoperative patients with stage IA lung adenocarcinoma (LUAD). This study aims to risk-stratify postoperative stage IA LUAD by means of the expression of Midkine (MDK). Materials and Methods:
Xiao Yang, PhD +10 more
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