Single-cell and spatial transcriptomics integration reveals FAM49B promotes tumor-associated macrophages polarization in colorectal cancer via the MK pathway [PDF]
Frontiers in ImmunologyObjectivesFAM49B has been shown to promote proliferation and metastasis of colorectal cancer (CRC) by stabilizing MYC through phosphorylation of NEK9; however, its role in shaping the immune suppressive tumor microenvironment (TME), particularly in ...
Tianyu Liu +12 more
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LBX2-AS1 in acceleration of glycolysis and cancer angiogenesis via miR-491-5p/MDK signaling axis in colorectal cancer: an experimental study [PDF]
Annals of MedicineBackground Recent studies have identified various roles for long non-coding RNAs (lncRNAs) in cancer progression. However, an in-depth understanding of the regulatory mechanisms of lncRNAs in colorectal cancer (CRC) and their diagnostic significance is ...
Juan Wang, Chao Li, Guanghai Wu, Jing Xu
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Midkine Promotes Tumor Growth and Attenuates the Effect of Cisplatin in Small Cell Lung Cancer [PDF]
Cancer MedicinePurpose Small cell lung cancer (SCLC) is a highly aggressive disease associated with poor patient survival rates. The addition of an anti‐programmed death ligand 1 antibody to platinum combination chemotherapy can improve its prognosis.
Shotaro Ito +16 more
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Targeting the MDK/c‐Myc complex to overcome temozolomide resistance in glioma [PDF]
Clinical and Translational MedicineBackground Temozolomide (TMZ), which is an alkylating agent, is the standard chemotherapeutic drug used for glioma treatment. However, the development of resistance to TMZ limits its efficacy.
Xiaonan Xi +7 more
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Single-cell and spatial dissection of necroptosis spatiotemporal evolution driving lymph node metastasis in gastric cancer [PDF]
Cell Death DiscoveryLymph node metastasis is a common metastatic route of gastric cancer. However, the heterogeneity of tumor cells and tumor microenvironment between primary gastric cancer and metastatic lymph nodes, as well as the driving mechanisms of metastasis, remain ...
Yuhua Hu +9 more
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Midkine (MDK) as a central regulator of the tumor microenvironment: From developmental cytokine to therapeutic target. [PDF]
Cancer LettNair HB +9 more
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Unraveling the Role of MDK‐SDC4 Interaction in Pancreatic Cancer‐Associated New‐Onset Diabetes by Single‐Cell Transcriptomic Analysis [PDF]
Advanced ScienceElevated blood glucose levels may serve as an early indicator of underlying pancreatic cancer. Discriminating between pancreatic cancer‐associated new‐onset diabetes (PCAND) and new‐onset type 2 diabetes mellitus (T2DM) holds promise for enabling an ...
Zengyu Feng +7 more
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Midkine (MDK) in cancer and drug resistance: from inflammation to therapy [PDF]
Discover OncologyMidkine (MDK) is a heparin-binding growth factor implicated in the pathogenesis of various diseases, including cancer, chronic inflammation, and multidrug resistance (MDR).
Berna Yıldırım +2 more
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Scientific ReportsThe efficacy of immunotherapy for clear cell renal cell carcinoma (ccRCC), especially advanced ccRCC, is limited, presenting a clinical challenge. This limitation is closely tied to the immune regulation network.
Naipeng Shi +6 more
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MDK — ein Risikofaktor für Universitätskliniken? [PDF]
InFo Neurologie & Psychiatrie, 2016 Hans-Christoph Diener, P Lütkes
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