Results 11 to 20 of about 1,892 (112)

Exosomal miR-9 inhibits angiogenesis by targeting MDK and regulating PDK/AKT pathway in nasopharyngeal carcinoma

Journal of Experimental & Clinical Cancer Research, 2018
Exosomes are small vesicles containing a wide range of functional proteins, mRNA and miRNA. Exosomal miRNAs from cancer cells play crucial roles in mediating cell-cell communication and tumor-microenvironment cross talk, specifically in enabling ...
Juan Lu, Qi-Hui Liu, Fan Wang, J. Tan, Yuemin Deng, Xiaohong Peng, Xiong Liu, Bao Zhang, Xia Xu, Xiangping Li   +9 more
semanticscholar   +3 more sources

LBX2-AS1 in acceleration of glycolysis and cancer angiogenesis via miR-491-5p/MDK signaling axis in colorectal cancer: an experimental study

Annals of Medicine
Background Recent studies have identified various roles for long non-coding RNAs (lncRNAs) in cancer progression. However, an in-depth understanding of the regulatory mechanisms of lncRNAs in colorectal cancer (CRC) and their diagnostic significance is ...
Juan Wang, Chao Li, Guanghai Wu, Jing Xu
semanticscholar   +3 more sources

Serum midkine levels for the diagnosis and assessment of response to interventional therapy in patients with hepatocellular carcinoma

Journal of Interventional Medicine, 2021
Objective: To explore the clinical significance of serum midkine (MDK) levels for the diagnosis of hepatocellular carcinoma (HCC) and evaluate the efficacy of interventional therapy.
Lin Zheng, Hailiang Li, Jinhua Huang, Jihoon Shin, Suxia Luo, Chenyang Guo, Yan Zhao, Fangkun Li   +7 more
doaj   +1 more source

Prognosis of Midkine and AT1R expression in resectable head and neck squamous cell carcinoma

Cancer Cell International, 2023
Background Research studies have demonstrated that Midkine (MDK) can influence the expression and activity of Renin-angiotensin system (RAS) components. Angiotensin II is involved in tumor growth and angiogenesis in different cancers.
Tai-Jan Chiu, Chang-Han Chen, Yi-Ju Chen, Yinshen Wee, Ching-Shuen Wang, Sheng‑Dean Luo   +5 more
doaj   +1 more source

Midkine promotes glioblastoma progression via PI3K-Akt signaling

Cancer Cell International, 2021
Background Our previous bioinformatics-based study found that midkine (MDK) was associated with poor prognosis of glioblastoma (GBM). However, the mechanism of MDK in GBM remains elusive.
Beiquan Hu, Chao Qin, Li Li, Lei Wei, Xianlun Mo, Huasheng Fan, Yuanhua Lei, Feng Wei, Donghua Zou   +8 more
doaj   +1 more source

Inhibition of Midkine Augments Osteoporotic Fracture Healing. [PDF]

PLoS ONE, 2016
The heparin-binding growth and differentiation factor midkine (Mdk) is proposed to negatively regulate osteoblast activity and bone formation in the adult skeleton.
Melanie Haffner-Luntzer, Julia Kemmler, Verena Heidler, Katja Prystaz, Thorsten Schinke, Michael Amling, Anna Kovtun, Anna E Rapp, Anita Ignatius, Astrid Liedert   +9 more
doaj   +1 more source

Midkine-deficiency delays chondrogenesis during the early phase of fracture healing in mice. [PDF]

PLoS ONE, 2014
The growth and differentiation factor midkine (Mdk) plays an important role in bone development and remodeling. Mdk-deficient mice display a high bone mass phenotype when aged 12 and 18 months. Furthermore, Mdk has been identified as a negative regulator
Melanie Haffner-Luntzer, Aline Heilmann, Anna Elise Rapp, Simon Beie, Thorsten Schinke, Michael Amling, Anita Ignatius, Astrid Liedert   +7 more
doaj   +1 more source

Clinical relevance of double‐arm blood pressure measurement and prevalence of clinically important inter‐arm blood pressure differences in Indian Primary Care

The Journal of Clinical Hypertension, Accepted Article., 2022
Abstract Hypertension guidelines recommend measuring blood pressure (BP) in both arms at least once. However, this is seldom done due to uncertainties regarding measurement procedure and the implications of finding a clinically important inter‐arm BP difference (IAD).
Gurpreet S. Wander, Sinead T.J. McDonagh, M. Srinivasa Rao, R. Alagesan, JC Mohan, Ajit Bhagwat, AK Pancholia, M. Viswanathan, Manoj Bhavrilal Chopda, A Purnanand, PLN kapardhi, Arun R Vadavi, R Selvaraj, Pankaj Aneja, Suhas Hardas, Neil Bordoloi, N Sivakadaksham, Christopher E goswami, Christopher E Clark, Willem J. Verberk   +19 more
wiley   +1 more source

Inhibition of the growth factor MDK/midkine by a novel small molecule compound to treat non-small cell lung cancer. [PDF]

PLoS ONE, 2013
Midkine (MDK) is a heparin-binding growth factor that is highly expressed in many malignant tumors, including lung cancers. MDK activates the PI3K pathway and induces anti-apoptotic activity, in turn enhancing the survival of tumors.
Huifang Hao, Yutaka Maeda, Takuya Fukazawa, Tomoki Yamatsuji, Munenori Takaoka, Xiao-Hong Bao, Junji Matsuoka, Tatsuo Okui, Tsuyoshi Shimo, Nagio Takigawa, Yasuko Tomono, Motowo Nakajima, Iris M Fink-Baldauf, Sandra Nelson, William Seibel, Ruben Papoian, Jeffrey A Whitsett, Yoshio Naomoto   +17 more
doaj   +1 more source

PERAN PEMANGKU KEPENTINGAN DALAM PELAKSANAAN MODEL DESA KONSERVASI DI TAMAN NASIONAL GUNUNG RINJANI

Jurnal Analisis Kebijakan Kehutanan, 2017
Pengembangan Model Desa Konservasi (MDK)  di Taman Nasional Gunung Rinjani (TNGR) diharapkan dapat meningkatkan keberdayaan masyarakat, namun fakta di lapangan program MDK belum berjalan optimal.
Andi Chairil Ichsan, Rinekso Soekmadi, Soeryo Adiwibowo, Cecep Kusmana   +3 more
doaj   +1 more source