Results 21 to 30 of about 1,892 (112)

Integrating single-cell RNA-seq and spatial transcriptomics reveals MDK-NCL dependent immunosuppressive environment in endometrial carcinoma

Frontiers in Immunology, 2023
Objectives The tumor microenvironment (TME) play important roles in progression of endometrial carcinoma (EC). We aimed to assess the cell populations in TME of EC.
Xinnian Yu, Linjun Xie, Jianjuan Ge, Huixin Li, Shanliang Zhong, Xiaolin Liu   +5 more
semanticscholar   +1 more source

Midkine’s Role in Cardiac Pathology

Journal of Cardiovascular Development and Disease, 2017
Midkine (MDK) is a heparin-binding growth factor that is normally expressed in mid-gestational development mediating mesenchymal and epithelial interactions. As organisms age, expression of MDK diminishes; however, in adults, MDK expression is associated
Kathleen C. Woulfe, Carmen C. Sucharov
doaj   +1 more source

Midkine noncanonically suppresses AMPK activation through disrupting the LKB1-STRAD-Mo25 complex

Cell Death and Disease, 2022
Midkine (MDK), a secreted growth factor, regulates signal transduction and cancer progression by interacting with receptors, and it can be internalized into the cytoplasm by endocytosis. However, its intracellular function and signaling regulation remain
Tian Xia, Di Chen, Xiaolong Liu, Huan Qi, Wen Wang, Huan Chen, Ting Ling, Wuxiyar Otkur, Chen-Song Zhang, Jongchan Kim, Sheng-Cai Lin, Hai-long Piao   +11 more
doaj   +1 more source

Disruption of Midkine gene reduces traumatic brain injury through the modulation of neuroinflammation

Journal of Neuroinflammation, 2020
Background Midkine (MK) is a multifunctional cytokine found upregulated in the brain in the presence of different disorders characterized by neuroinflammation, including neurodegenerative disorders and ischemia.
Seiya Takada, Harutoshi Sakakima, Takahiro Matsuyama, Shotaro Otsuka, Kazuki Nakanishi, Kosuke Norimatsu, Yuki Itashiki, Akira Tani, Kiyoshi Kikuchi   +8 more
doaj   +1 more source

Midkine Increases Diagnostic Yield in AFP Negative and NASH-Related Hepatocellular Carcinoma.

PLoS ONE, 2016
UnlabelledRobust biomarkers for population-level hepatocellular carcinoma (HCC) surveillance are lacking. We compared serum midkine (MDK), dickkopf-1 (DKK1), osteopontin (OPN) and AFP for HCC diagnosis in 86 HCC patients matched to 86 cirrhotics, 86 with
Roslyn Vongsuvanh, David van der Poorten, Tristan Iseli, Simone I Strasser, Geoffrey W McCaughan, Jacob George   +5 more
doaj   +1 more source

The role of midkine in health and disease

Frontiers in Immunology, 2023
Midkine (MDK) is a neurotrophic growth factor highly expressed during embryogenesis with important functions related to growth, proliferation, survival, migration, angiogenesis, reproduction, and repair.
Emely Elisa Neumaier, Veit Rothhammer, Mathias Linnerbauer   +2 more
doaj   +1 more source

Secreted proteins MDK, WFDC2, and CXCL14 as candidate biomarkers for early diagnosis of lung adenocarcinoma

BMC Cancer, 2023
Background Early diagnosis of lung adenocarcinoma (LUAD), one of the most common types of lung cancer, is very important to improve the prognosis of patients. The current methods can’t meet the requirements of early diagnosis. There is a pressing need to
Jun-Fang Li, Jianjie Li, Huifeng Hao, F. Lu, Jia Wang, Menglei Ma, B. Jia, M. Zhuo, Jingjing Wang, Y. Chi, Xiaoyu Zhai, Yuyan Wang, Mei-na Wu, T. An, Jun Zhao, Fan Yang, Ziping Wang   +16 more
semanticscholar   +1 more source

Machine learning identified MDK score has prognostic value for idiopathic pulmonary fibrosis based on integrated bulk and single cell expression data

Frontiers in Genetics, 2023
Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease that poses a significant challenge to medical professionals due to its increasing incidence and prevalence coupled with the limited understanding of its underlying molecular ...
Shichen Zhang, Lanlan Zhang, Lu Wang, Hongqiu Wang, Jiaxin Wu, Haoyang Cai, Chunheng Mo, Jian Yang   +7 more
semanticscholar   +1 more source

Midkine and Pleiotrophin Concentrations in Amniotic Fluid in Healthy and Complicated Pregnancies. [PDF]

PLoS ONE, 2016
Midkine (MDK) and pleiotrophin (PTN) are heparin-binding growth factors that, in rodents, are highly expressed in early life and decrease to undetectable levels by adulthood.
Youn Hee Jee, Yael Lebenthal, Piya Chaemsaithong, Gai Yan, Ivana Peran, Anton Wellstein, Roberto Romero, Jeffrey Baron   +7 more
doaj   +1 more source

Assessment of Agro-Ecological Apple Replant Disease (ARD) Management Strategies: Organic Fertilisation and Inoculation with Mycorrhizal Fungi and Bacteria

Agronomy, 2021
Apple replant disease (ARD) impacts the economic yield of orchards by physiological and morphological suppression of apple trees on replanted soils. The complexity of replant disease caused by a plethora of biological interactions and physical properties
Ulrike Cavael, Peter Lentzsch, Hilmar Schwärzel, Frank Eulenstein, Marion Tauschke, Katharina Diehl   +5 more
doaj   +1 more source