Results 231 to 240 of about 4,146,035 (404)

“Illuminating” Echinocandins’ Mechanism of Action

ACS Central Science, 2020
Boon Shing Loh, Wee Han Ang
doaj   +1 more source

Synergizing multimodal data and fingerprint space exploration for mechanism of action prediction. [PDF]

Bioinformatics
Hu K, Wei J, Sun C, Geng J, Wei L, Dai Q, Su R.   +6 more
europepmc   +1 more source

MECHANISM OF ACTION OF ORAL ANTI‐DIABETIC DRUGS [PDF]

, 1959
R Aiman, Nirmala Chaudhary
openalex   +1 more source

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

Molecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine, Sterenn Guillemot, Louis‐Bastien Weiswald, Romane Florent, Edwige Abeilard, Florence Giffard, Emilie Brotin, Mélanie Briand, Enora Dolivet, Laurent Poulain, Marie Villedieu   +10 more
wiley   +1 more source

Defining the mechanism of action of the nitrofuranyl piperazine HC2210 against Mycobacterium abscessus. [PDF]

NPJ Antimicrob Resist
Eke IE, Abdalla BJ, Soverina S, Olive AJ, Cicchetti N, Carey AF, Abramovitch RB.   +6 more
europepmc   +1 more source

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Spotlight on the Mechanism of Action of Semaglutide. [PDF]

Curr Issues Mol Biol
Papakonstantinou I, Tsioufis K, Katsi V.
europepmc   +1 more source

Mechanism of Hypotensive Action of Reserpine, an Alkaloid of Rauwolfia serpentina

, 1954
E. G. McQueen, A. E. Doyle, F. H. Smirk
openalex   +1 more source

Mechanism of Enzyme Action and Associated Cell Phenomena [PDF]

, 1930
F. F. Nord
openalex   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

Molecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song, Ting Liu, Qishan Hao, Qiuyun Fang, Xiaoyuan Gong, Yan Li, Zheng Tian, Hui Wei, Min Wang, Jianxiang Wang, Tao Cheng, Yingchang Mi   +11 more
wiley   +1 more source