Results 231 to 240 of about 3,894,411 (305)

Exploring the mechanism of action of Jinqiancao granules against liver cirrhosis based on the liver-gut axis. [PDF]

Front Pharmacol
Cheng FE, Zhang Y, Zheng S, Qi W, Zhang X, Li S, Wang Q, Zou X, Li X, Ye Y, Zao X.   +10 more
europepmc   +1 more source

MECHANISMS OF HORMONE ACTION

British Journal of Anaesthesia, 1981
openaire   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

The Mechanism of Action of Remote Electrical Neuromodulation (REN) in Treating Migraine and Potentially Other Idiopathic Pain Conditions. [PDF]

Curr Pain Headache Rep
Birlea M, Robinson CL, Mama E, Stark-Inbar A, Ironi A, Atashsokhan D, Berk T.   +6 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Integrated In Silico - In Vitro Study Investigating Dipeptides as Chorismate Synthase Modulators: Spotlight on Its Mechanism of Action. [PDF]

Glob Chall
Pedroni L, Fuchs K, Galaverna G, Macheroux P, Dellafiora L.   +4 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

In vitro, in silico, and DFT evaluation of antimicrobial imidazole derivatives with insights into mechanism of action. [PDF]

Sci Rep
Orujova NS, Abbasov VM, Jafarova RA, Mammadov AM, Bayil I, Muradova SA, Djadi N, Alqahtani T, Al-Dies AM, Zerihun YA, Guendouzi A, Zaki MEA.   +11 more
europepmc   +1 more source

Tanshinones target drug-resistant tuberculosis: efficacy, selectivity, and potential mechanism of action. [PDF]

RSC Med Chem
Polinário G, Rosa MABC, Campos DL, Moraes LLS, de Campos MMA, Silva IGM, Barros-Cordeiro KB, Báo SN, Pavan FR.   +8 more
europepmc   +1 more source

Rethinking miRNAs in MSC-sEV therapeutics: implications for manufacture, mechanism of action, and development of robust potency CQAs. [PDF]

Extracell Vesicles Circ Nucl Acids
Tan TT, Lim SK.
europepmc   +1 more source