Results 111 to 120 of about 10,274 (232)

Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy

British Journal of Pharmacology, Volume 183, Issue 5, Page 1122-1139, March 2026.
Abstract Background and Purpose Mavacamten (MAVA) is a novel small molecule inhibitor of cardiac myosin, mitigating cardiomyocyte hypercontractility in patients with hypertrophic obstructive cardiomyopathy (HOCM). Despite its recent approval for clinical use, the transcriptional and functional impacts of MAVA remain not well understood.
Elisa Kiselev, Wilson Agyapong, Bjarne Jürgens, Elisa Mohr, Shambhabi Chatterjee, Hannah J. Hunkler, Jawad Salman, Giuseppe Cipriano, Marco Bentele, Junqing Liu, Jonas Specht, Kaja S. Menge, Florian J. G. Waleczek, Jonas A. Haas, Anselm A. Derda, Kristina Sonnenschein, Anika Gietz, Susanne Neumüller, Angelika Pfanne, Oliver Beetz, Michael Pflaum, Bettina Wiegmann, Yiangos Psaras, Christopher Toepfer, Robert Zweigerdt, Ante Radocaj, Theresia Kraft, Andre Zeug, Evgeni Ponimaskin, Wilhelm Korte, Alexander Horke, Arjang Ruhparwar, Maximilian Fuchs, Ke Xiao, Christian Bär, Natalie Weber, Thomas Thum   +36 more
wiley   +1 more source

Computational Model for Cell Shape Regulation through Mechanosensing and Mechanical Feedback [PDF]

, 2014
Krithika Mohan, Tianzhi Luo, Douglas N. Robinson, Pablo A. Iglesias   +3 more
openalex   +1 more source

Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing [PDF]

, 2020
Emilie Marhuenda, Christine Fabre, Cunjie Zhang, Marta Martín-Fernández, Thomas Iskratsch, Ali Saleh, Luc Bauchet, Julien Cambedouzou, Jean‐Philippe Hugnot, Hugues Duffau, James W. Dennis, David Cornu, Norbert Bakalara   +12 more
openalex   +1 more source

Microscopic and molecular aspects of skeletal muscle alterations in cerebral palsy

Developmental Medicine &Child Neurology, Volume 68, Issue 3, Page 343-357, March 2026.
Cerebral palsy, caused by non‐progressive brain injury, is frequently accompanied by skeletal muscle alterations. This review synthesizes current evidence from muscle biopsy studies, revealing cellular and molecular adaptations in muscle tissue. Abstract Cerebral palsy (CP), the most prevalent childhood‐onset motor disability, frequently entails ...
Sebastian Edman, Oscar Horwath, Eva Pontén, Sudarshan Dayanidhi, Ferdinand von Walden   +4 more
wiley   +1 more source

Shear Stress and Sub-Femtomolar Levels of Ligand Synergize to Activate ALK1 Signaling in Endothelial Cells

Cells
Endothelial cells (ECs) respond to concurrent stimulation by biochemical factors and wall shear stress (SS) exerted by blood flow. Disruptions in flow-induced responses can result in remodeling issues and cardiovascular diseases, but the detailed ...
Ya-Wen Cheng, Anthony R. Anzell, Stefanie A. Morosky, Tristin A. Schwartze, Cynthia S. Hinck, Andrew P. Hinck, Beth L. Roman, Lance A. Davidson   +7 more
doaj   +1 more source

Role of mechanosensing machinery in muscle regeneration

, 2020
Yuji Hara, Kotaro Hirano, Seiji Takabayashi, Mari Takeuchi, Masaki Tsuchiya, Yasuo Mori, Masato Umeda   +6 more
openalex   +2 more sources

Impact of long‐term maternal high‐fat, high‐sugar feeding on gastric vagal afferent responses and feeding behaviour in mouse offspring

Experimental Physiology, Volume 111, Issue 3, Page 1330-1339, 1 March 2026.
Abstract Poor maternal nutrition and excessive gestational weight gain predict future development of obesity in offspring. Preclinically, maternal obesity induced by a high‐fat, high‐sugar diet (HFHSD) induces hyperphagia and obesity in offspring. We hypothesized that this might, in part, reflect reduced peripheral gastric vagal afferent (GVA) satiety ...
Georgia S. Clarke, Hui Li, Elaheh Heshmati, Kelly M. Gembus, Stephanie E. O'Hara, Lisa M. Nicholas, Kathryn L. Gatford, Amanda J. Page   +7 more
wiley   +1 more source

Mechanobiology in Action: Biomaterials, Devices, and the Cellular Machinery of Force Sensing

Biomolecules
Mechanical forces are increasingly recognised as fundamental regulators of cellular function, complementing classical biochemical cues to direct development, tissue homeostasis, and disease progression.
Miriam Lucariello, Maria Luisa Valicenti, Samuele Giannoni, Leonardo Donati, Ilaria Armentano, Francesco Morena, Sabata Martino   +6 more
doaj   +1 more source

Mechanosensing by the nucleus: From pathways to scaling relationships [PDF]

, 2017
Sang-Kyun Cho, Jerome Irianto, Dennis E. Discher   +2 more
openalex   +1 more source

Endothelial mechanosensing: A forgotten target to treat vascular remodeling in hypertension?

, 2022
Margherita Tiezzi, Hanqiang Deng, Nicolas Baeyens   +2 more
openalex   +2 more sources