Results 41 to 50 of about 10,274 (232)

Mechanoregulatory Effects of Cell‐Scale Microwells on Epithelial Cell Phenotype

Advanced Functional Materials, EarlyView.
In small polycaprolactone microwells, A549 epithelial cells span well edges, in contrast to cells growing on flat substrates. Focal adhesion sites (yellow) concentrate at topographic boundaries, while cytoskeletal tension (magenta stress fibers) is transmitted to the nucleus (blue), reducing nuclear sphericity.
Ruiwen He, Wang Sik Lee, Phattadon Yajan, Aaron Lee, Mauro Sousa de Almeida, Sandeep Keshavan, Jozef Adamcik, Céline Loussert‐Fonta, Dimitri Vanhecke, Barbara Rothen‐Rutishauser, Alke Petri‐Fink   +10 more
wiley   +1 more source

Multiscale Hybrid Surface Topographies Orchestrate Immune Regulation, Antibacterial Defense, and Tissue Regeneration

Advanced Healthcare Materials, EarlyView.
Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash, Jacob Robins, J. Scott VanEpps, Minji Kim, Jouha Min   +4 more
wiley   +1 more source

Parallel Processing of Olfactory and Mechanosensory Information in the Honey Bee Antennal Lobe

Frontiers in Physiology, 2021
In insects, neuronal responses to clean air have so far been reported only episodically in moths. Here we present results obtained by fast two-photon calcium imaging in the honey bee Apis mellifera, indicating a substantial involvement of the antennal ...
Ettore Tiraboschi, Ettore Tiraboschi, Luana Leonardelli, Luana Leonardelli, Gianluca Segata, Albrecht Haase, Albrecht Haase   +6 more
doaj   +1 more source

Mechanosensing of substrate thickness [PDF]

Physical Review E, 2010
Structure and function of the adherent cell depend in a crucial way on its microenvironment, including the stiffness of its substrate. It is often asserted that substrate thickness (as opposed to stiffness) plays a negligible role and therefore may be considered semi-infinite.
Yu-Chun Lin, Dhananjay T. Tambe, Chan Young Park, Michael R. Wasserman, Xavier Trepat, Ramaswamy Krishnan, Guillaume Lenormand, Jeffrey J. Fredberg, James P. Butler   +8 more
openaire   +3 more sources

A Modular Bioinstructive Platform Reveals Mechanistic Insights into Additive‐Free, Topography‐Driven Osteogenesis

Advanced Healthcare Materials, EarlyView.
Engineered microparticle topographies direct human mesenchymal stem cell osteogenesis without biochemical additives. This osteogenic commitment is driven by canonical Hedgehog signaling and followed by temporal IGF‐II engagement. Two‐photon polymerization demonstrates spatial control, enabling the engineering of topographical gradients that pattern ...
Fatmah I. Ghuloum, Leo A. H. Zeef, Lee A. Stevens, Marco A. N. Domingos, Susan J. Kimber, Mahetab H. Amer   +5 more
wiley   +1 more source

Vesicles with internal active filaments: self-organized propulsion controls shape, motility, and dynamical response

New Journal of Physics, 2019
Self-propulsion and navigation due to the sensing of environmental conditions—such as durotaxis and chemotaxis—are remarkable properties of biological cells that cannot be modeled by single-component self-propelled particles.
Clara Abaurrea-Velasco, Thorsten Auth, Gerhard Gompper   +2 more
doaj   +1 more source

Human Atrial Fibroblast Adaptation to Heterogeneities in Substrate Stiffness

Frontiers in Physiology, 2020
Fibrosis is associated with aging and many cardiac pathologies. It is characterized both by myofibroblast differentiation and by excessive accumulation of extracellular matrix proteins. Fibrosis-related tissue remodeling results in significant changes in
Ramona Emig, Ramona Emig, Ramona Emig, Callum M. Zgierski-Johnston, Callum M. Zgierski-Johnston, Friedhelm Beyersdorf, Friedhelm Beyersdorf, Bartosz Rylski, Bartosz Rylski, Ursula Ravens, Ursula Ravens, Wilfried Weber, Wilfried Weber, Peter Kohl, Peter Kohl, Peter Kohl, Maximilian Hörner, Maximilian Hörner, Rémi Peyronnet, Rémi Peyronnet   +19 more
doaj   +1 more source

Flagellar Motor Transformed: Biophysical Perspectives of the Myxococcus xanthus Gliding Mechanism

Frontiers in Microbiology, 2022
Many bacteria move on solid surfaces using gliding motility, without involvement of flagella or pili. Gliding of Myxococcus xanthus is powered by a proton channel homologous to the stators in the bacterial flagellar motor. Instead of being fixed in place
Jing Chen, Beiyan Nan
doaj   +1 more source

Mechanosensation: Tethered Ion Channels [PDF]

Current Biology, 2013
Two new studies show that the Drosophila transient receptor potential (TRP) family member NOMPC forms both a mechanically gated ion channel and a fine filament that, by tethering the protein to microtubules, might act as a gating spring.
Zanini, Damiano, Göpfert, Martin C.
openaire   +3 more sources

Automating Vascular Biology: An End‐to‐End Automated Workflow for High‐Throughput Blood Vessel‐on‐a‐Chip Production and Multi‐Site Validation

Advanced Healthcare Materials, EarlyView.
AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin, Hanieh Mohammad Hashemi, Kimia Asadi Jozani, Anushree Chakravarty, Sonya Kouthouridis, Jessica Bonanno, Nicky Anvari, Shravanthi Rajasekar, Feng Zhang, Richard Y. Cheng, Narendra Kumar Singh, Luis Miguel Medina, Marc Durante, Yufang He, Boyang Zhang   +14 more
wiley   +1 more source