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Cellular Fluid Mechanics and Mechanotransduction

Annals of Biomedical Engineering, 2005
Mechanotransduction, the transformation of an applied mechanical force into a cellular biomolecular response, is briefly reviewed focusing on fluid shear stress and endothelial cells. Particular emphasis is placed on recent studies of the surface proteoglycan layer (glycocalyx) as a primary sensor of fluid shear stress that can transmit force to apical
John M, Tarbell   +2 more
openaire   +2 more sources

The role of microtopography in cellular mechanotransduction

Biomaterials, 2012
Mechanotransduction is crucial for cellular processes including cell survival, growth and differentiation. Topographically patterned surfaces offer an invaluable non-invasive means of investigating the cell response to such cues, and greater understanding of mechanotransduction at the cell-material interface has the potential to advance development of ...
Laura E, McNamara   +7 more
openaire   +2 more sources

Cellular Basis of Mechanotransduction

The Biological Bulletin, 1998
Physical forces, such as those due to gravity are fundamental regulators of tissue development. To influence morphogenesis, mechanical forces must alter growth and function. Yet little is known about how cells convert mechanical signals into a chemical response.
openaire   +2 more sources

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