Results 261 to 270 of about 39,386 (288)

Mechanotransduction in adipocytes

Journal of Biomechanics, 2012
Obesity is widely recognized as a major public health problem due to its strong association with a number of serious chronic diseases including hyperlipidemia, hypertension, type II diabetes and coronary atherosclerotic heart disease. During the development of obesity, the positive energy balance involves recruitment of new adipocytes from ...
Naama, Shoham, Amit, Gefen
openaire   +2 more sources

The role of the cell nucleus in mechanotransduction.

Current Opinion in Cell Biology, 2020
Mechanical forces are known to influence cellular processes with consequences at the cellular and physiological level. The cell nucleus is the largest and stiffest organelle, and it is connected to the cytoskeleton for proper cellular function.
Cátia S. Janota, Francisco J. Calero-Cuenca, E. Gomes   +2 more
semanticscholar   +1 more source

Genetics of Sensory Mechanotransduction

Annual Review of Genetics, 2002
▪ Abstract  The molecular mechanisms for the transduction of light and chemical signals in animals are fairly well understood. In contrast, the processes by which the senses of touch, balance, hearing, and proprioception are transduced are still largely unknown.
Glen G, Ernstrom, Martin, Chalfie
openaire   +2 more sources

Cell–extracellular matrix mechanotransduction in 3D

Nature reviews. Molecular cell biology, 2023
Aashrith Saraswathibhatla, Dhiraj Indana, Ovijit Chaudhuri   +2 more
semanticscholar   +1 more source

Biomaterials and bone mechanotransduction

Biomaterials, 2001
Bone is an extremely complex tissue that provides many essential functions in the body. Bone tissue engineering holds great promise in providing strategies that will result in complete regeneration of bone and restoration of its function. Currently, such strategies include the transplantation of highly porous scaffolds seeded with cells.
V I, Sikavitsas, J S, Temenoff, A G, Mikos   +2 more
openaire   +2 more sources

Mechanisms of Osteocyte Mechanotransduction

Clinical Reviews in Bone and Mineral Metabolism, 2010
Healthy bones combine a proper resistance against fracture with a minimum use of material. This property is likely brought about by osteocytes in response to mechanical cues, but it is still unknown how whole bone loads are translated into a signal that can be sensed by the osteocytes.
Bakker, A.D., Klein Nulend, J.
openaire   +4 more sources

Molecular regulation of mechanotransduction

Biochemical and Biophysical Research Communications, 2005
There is a common mechanism for mechanotransduction in cells, regardless of the cell type. Integrins, interacting with their matrix/environment, mediate increases in intracellular Ca2+ levels and activate MAP kinase cascades to cause ERK1/2 phosphorylation. Phosphorylated ERK1/2 causes the activation of the AP-1 family of transcription factors that are
Jameel, Iqbal, Mone, Zaidi
openaire   +2 more sources

Role of YAP/TAZ in mechanotransduction

Nature, 2011
S. Dupont, Leonardo Morsut, M. Aragona, E. Enzo, S. Giulitti, M. Cordenonsi, F. Zanconato, J. L. Digabel, M. Forcato, S. Bicciato, N. Elvassore, S. Piccolo   +11 more
semanticscholar   +1 more source

Mechanotransduction and focal adhesions

Cell Biology International, 2012
AbstractCellular FAs (focal adhesions) respond to internal and external mechanical stresses which make them prime candidates for mechanotransduction. Recent observations showed that the FA proteins including vinculin, FAK (FA kinase) and p130Cas are crucial for the ability of cells to transmit forces and to generate cytoskeletal tension.
openaire   +2 more sources

Crosstalk between mechanotransduction and metabolism

Nature reviews. Molecular cell biology, 2020
P. Romani, Lorea Valcarcel-Jimenez, C. Frezza, S. Dupont   +3 more
semanticscholar   +1 more source