Results 81 to 90 of about 39,386 (288)
Mechanotranduction Pathways in the Regulation of Mitochondrial Homeostasis in Cardiomyocytes
Frontiers in Cell and Developmental Biology, 2021 Mitochondria are one of the most important organelles in cardiomyocytes. Mitochondrial homeostasis is necessary for the maintenance of normal heart function.
Hongyu Liao +5 more
doaj +1 more source
Viscoelasticity, Like Forces, Plays a Role in Mechanotransduction
Frontiers in Cell and Developmental Biology, 2022 Viscoelasticity and its alteration in time and space has turned out to act as a key element in fundamental biological processes in living systems, such as morphogenesis and motility.
C. Mierke
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.Quantum sensing reveals intricate patterns linking endo‐lysosomal maturation to cardiac fibrosis progression, highlighting complexity in cellular remodeling. This study investigates fibroblast‐to‐myofibroblast transition under cell aging, stiffness, and TGF‐β stimulation, comparing nanodiamond uptake, endo‐lysosomal dynamics, and free radical ...
Aldona Mzyk +3 more
wiley +1 more source
Engineering Reports, 2020 Stem cell‐based cartilage regeneration strategies take benefits from functional tissue engineering concepts that effectively exploit cells native mechanotransduction phenomenon for the development of in vitro cartilage constructs.
Nirmal S. Remya, Prabha D. Nair
doaj +1 more source
Mechanoregulatory Effects of Cell‐Scale Microwells on Epithelial Cell Phenotype
Advanced Functional Materials, EarlyView.In small polycaprolactone microwells, A549 epithelial cells span well edges, in contrast to cells growing on flat substrates. Focal adhesion sites (yellow) concentrate at topographic boundaries, while cytoskeletal tension (magenta stress fibers) is transmitted to the nucleus (blue), reducing nuclear sphericity.
Ruiwen He +10 more
wiley +1 more source
Advanced Functional Materials, EarlyView.MagPiezo enables wireless activation of endogenous Piezo1 channels without genetic modification using 19 nm magnetic nanoparticles and low‐intensity magnetic fields. It generates torque forces at the piconewton scale to trigger mechanotransduction in endothelial cells, standing as a novel platform to interrogate and manipulate Piezo1 activity in vitro.
Susel Del Sol‐Fernández +7 more
wiley +1 more source
BioengineeringIn this review, we explore the intricate relationship between glucose metabolism and mechanotransduction pathways, with a specific focus on the role of the Hippo signaling pathway in chondrocyte pathophysiology.
Jacob Jahn +5 more
doaj +1 more source
Matrix mechanotransduction mediated by thrombospondin-1/integrin/YAP in the vascular remodeling
Proceedings of the National Academy of Sciences of the United States of America, 2020 Significance We propose a mechanism of matrix mechanotransduction initiated by thrombospondin-1 (Thbs1), connecting mechanical stimuli to Yes-associated protein (YAP) signaling during vascular remodeling.
Yoshito Yamashiro +9 more
semanticscholar +1 more source
AIMS Biophysics, 2016 Cell adhesion and cell–cell contacts are pre-requisites for proper metabolism, protein synthesis, cell survival, and cancer metastasis. Major transmembrane receptors are the integrins, which are responsible for cell matrix adhesions, and the cadherins, which are important for cell-cell adhesions. Adherent cells are anchored via focal adhesions ...
Wolfgang H. Goldmann, José Luis Alonso
openaire +2 more sources
Advanced Healthcare Materials, EarlyView.Hybrid wrinkled topographies coordinate immune, tissue, and bacterial interactions. The surfaces promote osteointegration, tune macrophage polarization, and inhibit biofilm formation, highlighting a multifunctional strategy for next‐generation implant design.
Mohammad Asadi Tokmedash +4 more
wiley +1 more source