Results 11 to 20 of about 8,368,619 (264)

Exploring the Median Effective Dose of Ciprofol for Anesthesia Induction in Elderly Patients: Impact of Frailty on ED50 [PDF]

Drug Design, Development and Therapy
Jingjing Yuan,1,2,* Zenghui Liang,1,* Muhoza Bertrand Geoffrey,1 Yanle Xie,1,2 Shuhan Chen,1,2 Jing Liu,1,2 Yuzhong Xia,1 Huixin Li,1 Yanling Zhao,1 Yuanyuan Mao,1,2 Na Xing,1,2 Jianjun Yang,1,2 Zhongyu Wang,1 Fei Xing1,2 1Department of ...
Yuan J, Liang Z, Geoffrey MB, Xie Y, Chen S, Liu J, Xia Y, Li H, Zhao Y, Mao Y, Xing N, Yang J, Wang Z, Xing F   +13 more
doaj   +3 more sources

The new algorithm for calculation of median lethal dose (LD50) and effective dose fifty (ED50) of Micrarus fulvius venom and anti-venom in mice [PDF]

International Journal of Veterinary Science and Medicine, 2016
One million people throughout the world are bitten yearly by poisonous snakes. Of this, one-tenth died and three-tenth suffer some forms of disabilities.
Saganuwan Alhaji Saganuwan
doaj   +3 more sources

Median effective dose of nefopam to treat postoperative pain in patients who have undergone laparoscopic cholecystectomy

Journal of International Medical Research, 2018
Objective Nefopam is thought to reduce postoperative pain; however, the evidence is insufficient. The recommended dose is 20 mg, and the median effective dose (ED50) in the surgical setting reportedly ranges from 17 to 28 mg.
Heezoo Kim, Dong Kyu Lee, Mi Kyoung Lee, Mido Lee   +3 more
doaj   +3 more sources

Estimation of the median effective dose and the 95% effective dose of alfentanil required to inhibit the bronchoscopy reaction during painless bronchoscopy with i-gel supraglottic airway device: an Up-and-Down Sequential Allocation Trial. [PDF]

J Thorac Dis, 2022
Background In practice, the optimal dose of alfentanil that should be used when painless bronchoscopy is performed is unknown. The purpose of this study was to investigate the effective dose of alfentanil in suppressing bronchoscopy responses to painless
Chen N, Wang X, Chen L, Wang M, Jiang Y.
europepmc   +2 more sources

Median Effective Dose of Esketamine Combined with Remifentanil for Anesthesia Induction in Painless Colonoscopy [PDF]

Therapeutics and Clinical Risk Management
Zhengqing Cao,1,* Haixia Xue,2,* Huilian Wang,3 Xin Liu21Department of Anorectal Surgery, Northern Jiangsu People’s Hospital Affiliated to Yangzhou University, Northern Jiangsu People’s Hospital, Yangzhou, Jiangsu, 225000, People’s ...
Cao Z, Xue H, Wang H, Liu X
doaj   +2 more sources

Determination of the median effective dose (ED₅₀) of oliceridine combined with propofol for inhibiting gastroscope insertion responses in adult patients undergoing painless gastroscopy [PDF]

Frontiers in Medicine
BackgroundPropofol is the most frequently administered intravenous anesthetic in painless gastroscopy. Oliceridine, a novel μ-opioid receptor agonist, exhibits analgesic effects while reducing adverse reactions.
Xiaojing Zhang, Weimin Qin, Xinying Zhang, Wenbo Liang, Zhiqiang Ren, Qing Ma, Li Zhou, Longbin Zheng, Longbin Zheng   +8 more
doaj   +2 more sources

Median Effective Dose of Ciprofol Combined With Sufentanil for Inhibiting the Upper Gastrointestinal Endoscopic Placement Reaction in Elderly Patients. [PDF]

Dose Response
Objective Ciprofol is a new sedative anesthetic drug that can be used for gastrointestinal endoscopy and induction of general anesthesia, but the appropriate dosage for use in elderly patients has not been determined. Sufentanil is a commonly used opioid
Xiong H, Xu H, Yang Y, Hu B, Jiang K, Zou X.   +5 more
europepmc   +2 more sources

Median effective dose of rocuronium for the prevention of succinylcholine-induced fasciculation: an age-stratified study [PDF]

BMC Anesthesiology
Background Succinylcholine, a commonly used depolarizing neuromuscular blocking relaxant, may produce fasciculation and postoperative myalgia as adverse effects.
Shunping Tian, Chao Chen, Shuping Wang, Shantian Feng, Meng Wang, Xuhong Liu, Tianxiu Bao, Zhuan Zhang   +7 more
doaj   +2 more sources

Median effective dose and 95% effective dose of oliceridine combined with ciprofol for painless gastroscopy: a dose-finding study based on Dixon’s up-and-down method [PDF]

Frontiers in Pharmacology
ObjectiveTo determine the median effective dose and estimate 95% effective dose of oliceridine combined with ciprofol for suppressing gastroscope insertion responses, stratified by sex.MethodsThis prospective, sex-stratified trial enrolled patients ...
Xikun Sun, Pei Song, Bin Zou, Yimeng Zhuang, Xiaohang Han, Jianyu Zu, Yugang Diao   +6 more
doaj   +2 more sources

Circadian Variation in the Median Effective Dose of Epidural Ropivacaine for Labor Analgesia [PDF]

Frontiers in Medicine, 2021
Background: Labor pain perception has been demonstrated to exhibit a circadian rhythm with lower pain scores during the day compared with the night. This study aimed to determine and compare the median effective dose (ED50) of ropivacaine in parturients ...
Jiali Deng, Jiali Deng, Changna Wei, Changna Wei, Lin Liu, Jing Qian, Fei Xiao, Fei Xiao, Xinzhong Chen   +8 more
doaj   +2 more sources