Combined sedation in pediatric magnetic resonance imaging: determination of median effective dose of intranasal dexmedetomidine combined with oral midazolam. [PDF]
BMC AnesthesiolBackground The exact median effective dose (ED50) of intranasal dexmedetomidine combined with oral midazolam sedation for magnetic resonance imaging (MRI) examination in children remains unknow and the aim of this study was to determine the ED50 of their
Xie H, Zhao J, Tu H, Wang W, Hu Y.
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Determination of the median effective dose of sufentanil for inhibiting the laryngeal mask insertion response in geriatric patients: a prospective, double-blinded, dose–response trial [PDF]
BMC Anesthesiology, 2022 Background Laryngeal mask airway(LMA) have been widely used in clinical practice. Irritation to the patient during the insertion of a laryngeal mask can cause hemodynamic fluctuations, which is particularly unsafe for geriatric patients.
ShiFang Wang +5 more
doaj +2 more sources
The median effective dose (ED50) of cis-Atracurium for laryngeal mask airway insertion during general Anaesthesia for patients undergoing urinary surgery. [PDF]
BMC Anesthesiol, 2020 In clinical practice, the laryngeal mask airway is an easy-to-use supraglottic airway device. However, the cis-atracurium dosage for laryngeal mask insertion has not been standardised.
Wang X +7 more
europepmc +2 more sources
The median effective dose of propofol combined with butorphanol during artificial abortion: a randomized controlled trial [PDF]
Frontiers in Medicine, 2023 ObjectivePropofol-opioids are the most common drug combination and can reduce the dose of propofol and the incidence of adverse events in painless artificial abortion.
Yuling Zheng +4 more
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Median effective dose (ED50) of esketamine combined with different doses of propofol for children to inhibit the response to gastroscope insertion: a prospective dose–response clinical study [PDF]
BMC AnesthesiologyBackground This study aimed to evaluate whether combining esketamine with different doses of propofol could reduce drug requirements and minimize adverse effects in children undergoing gastroscopy.
Keqing Niu +4 more
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Median effective dose of intravenous nalmefene for preventing sufentanil-induced cough in children aged 1–6 years: a prospective randomized controlled trial [PDF]
Frontiers in PediatricsBackgroundSufentanil-induced cough (SIC) during anesthetic induction carries greater risks in young children than in adults owing to their limited functional residual capacity and elevated oxygen demand.
Chao Wang +5 more
doaj +2 more sources
The median effective dose of esketamine with different doses of oliceridine during hysteroscopic surgery [PDF]
Frontiers in PharmacologyPurposeThis study aimed to investigate the impact of different doses of oliceridine on the ED50 of esketamine during hysteroscopic surgery. The objective was to establish an optimal dosing regimen that facilitates the development of an effective and safe
Min Shi +6 more
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Age‑stratified median effective dose (ED₅₀) of remimazolam besylate for successful gastroscope insertion without body movement in geriatric patients [PDF]
BMC AnesthesiologyBackground Remimazolam besylate is increasingly used for procedure sedation anesthesia (PSA) in gastrointestinal endoscopy, but age‑specific dosing for elderly patients is unclear.
Si-Qi Hao +4 more
doaj +2 more sources
Chinese Medical Journal, 2018 Background: Intravenous (IV) oxycodone has been used at induction to prevent an intubation reaction. The aims of the current study were to calculate the median effective dose (ED50) and the 95% effective dose (ED95) of an IV bolus of oxycodone that ...
Xian-Hui Kang +6 more
doaj +2 more sources
Effects of voltage-gated sodium channels on the median effective dose of ropivacaine in diabetic rats [PDF]
Scientific ReportsDiabetes mellitus significantly impacts perioperative anesthetic management. Patients with diabetic neuropathy exhibit increased sensitivity to local anesthetics, yet the underlying mechanisms, particularly regarding the median effective dose (ED50) of ...
Xueyin Song +8 more
doaj +2 more sources