Results 21 to 30 of about 425,006 (219)

Effect of age on the median effective dose and 95% effective dose of intravenous fentanyl for blunting the hemodynamic response to tracheal intubation: A double-blind, up-and-down sequential method trial [PDF]

Journal of Anaesthesiology Clinical Pharmacology
Background and Aims: Control of the hemodynamic response during intubation is essential. To assess the effect of age on the median effective dose (ED50) and 95% effective dose (ED95) of fentanyl for blunting the hemodynamic response to intubation ...
Jatuporn Eiamcharoenwit, Phuping Akavipat   +1 more
doaj   +2 more sources

Combined sedation in pediatric magnetic resonance imaging: determination of median effective dose of intranasal dexmedetomidine combined with oral midazolam [PDF]

BMC Anesthesiology
Background The exact median effective dose (ED50) of intranasal dexmedetomidine combined with oral midazolam sedation for magnetic resonance imaging (MRI) examination in children remains unknow and the aim of this study was to determine the ED50 of their
Hao Xie, Jialian Zhao, Haiya Tu, Wenyang Wang, Yaoqin Hu   +4 more
doaj   +2 more sources

Antivenoms: potency or median effective dose, which to use? [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2010
V Morais, S Ifran, P Berasain, H Massaldi   +3 more
doaj   +3 more sources

Effect of methotrexate on neurobehavior and cholinesterase in chicks [PDF]

Iraqi Journal of Veterinary Sciences, 2023
This reading aimed to determine the therapeutic index of methotrexate (MTX) with a note on the consequence of methotrexate in chicks on neurobehavioral in addition to calculating the activity for cholinesterase in plasma and brain in chicks.
Maab A. Fadel, Khayrea A. Mustafa, Imad A. Thanoon   +2 more
doaj   +1 more source

Assessing a 6-h endpoint observation time in the lethality neutralization assay used to evaluate the preclinical efficacy of snake antivenoms

Toxicon: X, 2021
The lethality neutralization assay in mice is the gold standard for the evaluation of the preclinical efficacy and specification fulfillment of snake antivenoms. However, owing to the animal suffering involved, this assay is a candidate to be replaced by
Gina Durán, Gabriela Solano, Aarón Gómez, Daniel Cordero, Adriana Sánchez, Mauren Villalta, Melvin Sánchez, Cecilia Díaz, José María Gutiérrez, Guillermo León   +9 more
doaj   +1 more source

ED50 of Propofol Combined with Nalbuphine on the Sedative Effect in Painless Hysteroscopy

Pain and Therapy, 2021
Introduction Nalbuphine has gradually become a commonly used clinical analgesic drug for painless hysteroscopy. The aim of our study was to identify the median effective dose (ED50) of propofol combined with nalbuphine for painless hysteroscopy.
Chen Chen, Weixiang Tang, Wei Ye, Weiwei Zhong, Yuanhai Li   +4 more
doaj   +1 more source

Determination of pesticide toxicity parameters using probit-analysis

Карантин і захист рослин, 2023
Goal of the research is to consider the main concepts used in the probit-analysis method, the features of its application to determine the toxicity of pesticides, in particular insecticides, acaricides and fungicides. Methods.
O. Shevchuk, O. Vlasova, I. Shevchuk, Yu. Stefkivska   +3 more
doaj   +1 more source

Effect of Baricity of Bupivacaine on Median Effective Doses for Motor Block [PDF]

Medical Science Monitor, 2017
BACKGROUND The median effective dose (ED50) of a drug gives the amount or dose of drug needed to produce effective therapeutic response or desired effect in at least 50% of the population taking it. Our study focused on determining the ED50 required for effective motor block using hyperbaric and plain bupivacaine, and evaluated the influence of ...
Chen, Ming-quan, Chen, Chun, Li, Lin
openaire   +2 more sources

Effects of intrathecal and i.v. small-dose sufentanil on the median effective dose of intrathecal bupivacaine for Caesarean section [PDF]

British Journal of Anaesthesia, 2007
Spinal anaesthesia with bupivacaine combined with sufentanil has been widely used for Caesarean section. However, the main site of action (spinal vs central) of intrathecal (IT) sufentanil is controversial. The aim of this study was to examine the predominant mechanism of action of IT, small-dose sufentanil when added to bupivacaine for Caesarean ...
L Z, Wang, Y F, Zhang, B L, Tang, K Z, Yao   +3 more
openaire   +3 more sources

ED50 and ED95 of Propofol Combined with Different Doses of Intravenous Lidocaine for First-Trimester Uterine Aspiration: A Prospective Dose-Finding Study Using Up-and-Down Sequential Allocation Method

Drug Design, Development and Therapy, 2022
Jingwen Zhang,1 Linglingli Kong,2 Juan Ni1 1Department of Anesthesiology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education ...
Zhang J, Kong L, Ni J
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