Results 41 to 50 of about 4,221 (131)

The median effective dose of propofol combined with butorphanol during artificial abortion: a randomized controlled trial

Frontiers in Medicine, 2023
ObjectivePropofol-opioids are the most common drug combination and can reduce the dose of propofol and the incidence of adverse events in painless artificial abortion.
Yuling Zheng, Jinping Huang, Ying Mai, Xiaoling Li, Zhongqi Zhang   +4 more
doaj   +1 more source

A PK/PD study on antihyperalgesia by an α2/3‐GABAA receptor PAM in mice: Lack of tolerance liability and potential involvement of γ1‐GABAA receptors

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose GABAA receptors (GABAARs) are heteropentameric ion channels that control almost all CNS functions, including spinal nociception. Most GABAARs contain a γ2 subunit but differ in their α and β subunit composition. TPA023B is an α2/α3 subtype selective, non‐sedative, positive allosteric modulator (PAM) with antihyperalgesic
Elena Neumann, Mariana O. Popa, Karen T. Elvers, Misa Oyama, Daniel Ulrich, Marcus Hanley, Gui Jie Feng, Thomas Hathaway, William T. Ralvenius, Thomas Grampp, Dietmar Benke, John R. Atack, Hanns Ulrich Zeilhofer   +12 more
wiley   +1 more source

Dose‐Escalation Regimens for Incretin Mimetics in Type 2 Diabetes Are Associated With Tolerance for Nausea and Vomiting

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims/Hypothesis Initial dose‐escalation has been shown to mitigate gastrointestinal adverse events in people treated with incretin‐based medications. We aimed to analyse dose‐response relationships for the proportion of study participants reporting nausea and vomiting among those exposed to incretin mimetics approved for Type 2 diabetes (GLP‐1
Michael A. Nauck, Viktoria Punov, Yu Mi Kang, Soo Lim   +3 more
wiley   +1 more source

Comparative Toxicity of Bordeaux Mixture by Ingestion and Cuticular Contact Under Climate Change Conditions on Trichogramma cordubensis

Entomologia Experimentalis et Applicata, EarlyView.
In the face of environmental contamination to copper, mainly resulting from frequent copper‐based fungicide applications, it is crucial to understand the side effects of these pesticides on non‐target organisms to improve pest management. Trichogramma cordubensis, used as a biological control agent against grape berry moths in vineyards, shows strongly
William Nusillard, Tessie Garinie, Géraldine Groussier, Denis Thiéry, Jacques Frandon, Jérôme Moreau   +5 more
wiley   +1 more source

Meta‐analysis of genetic mapping studies in mice reveals candidate epilepsy modifier genes that are outside the current drug development landscape

Epilepsia, EarlyView.
Abstract Objective Despite decades of development in anti‐seizure medications, ~30% of individuals remain refractory to all treatments, and none of the existing therapies are disease modifying. Identifying targets outside the current preclinical paradigm is critically important.
Giovanna L. Durante, Anna L. Tyler, Rod C. Scott, Amanda E. Hernan, J. Matthew Mahoney   +4 more
wiley   +1 more source

Synergism of the analgesic activities of tramadol with α2 adrenoreceptor agonist xylazine in mice [PDF]

Iraqi Journal of Veterinary Sciences, 2012
The present study was undertaken to evaluate the antinociceptive interaction between tramadol and xylazine. The antinociceptive effect of intraperitoneal (I.P) administration of the drug alone or in combination was evaluated using the mouse hot-plate ...
G. A. Taqa
doaj  

ED50 and ED95 of Propofol Combined with Different Doses of Intravenous Lidocaine for First-Trimester Uterine Aspiration: A Prospective Dose-Finding Study Using Up-and-Down Sequential Allocation Method

Drug Design, Development and Therapy, 2022
Jingwen Zhang,1 Linglingli Kong,2 Juan Ni1 1Department of Anesthesiology, West China Second University Hospital, Sichuan University, Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education ...
Zhang J, Kong L, Ni J
doaj  

Nilai Indeks Terapi Ekstrak Etanol Daun Dewa {Gynura pseudochina (Lour.) DC} dan Natrium Diklofenak pada Tikus Model Inflamasi

Majalah Kedokteran Bandung, 2012
Therapeutic index, a drug safety parameter, is comparation between the dose at which 50% animals are dead (LD50) and the dose at which 50% animals exhibit the specified effect (ED50).
Donaliazarti , Truly Sitorus, Josep I. Sigit,, Muchtan Sudjatno   +3 more
doaj   +1 more source

Assessing D‐Squame as a Minimally Invasive Technique to Evaluate the Cutaneous Immune Response mRNA in a Dog Model of Canine Atopic Dermatitis

Veterinary Dermatology, EarlyView.
ABSTRACT Background Canine atopic dermatitis (cAD) is a multifactorial, inherited skin disease, estimated to affect ≤ 15% of dogs. Studies of skin messenger mRNA in cAD currently use invasive methods, including blood sampling and biopsy collection, whilst advances in human atopic dermatitis study methodology have demonstrated reliable use of minimally ...
Xavier Langon, Marion Mosca, Nadège Milhau, Mélanie Legain, Adrien Idée, Didier Pin   +5 more
wiley   +1 more source

Straight to Phase III: Model‐Informed Approach Speeds Depemokimab Clinical Development in Interleukin‐5‐Driven Diseases

Clinical Pharmacology &Therapeutics, Volume 119, Issue 4, Page 1005-1015, April 2026.
Straight to Phase III: Model‐informed approach speeds depemokimab clinical development in interleukin‐5‐driven diseases. IL‐5, a key mediator of type 2 inflammation, underlies various diseases, including severe asthma, CRSwNP, EGPA, and HES. Reduction in blood eosinophil count (BEC), a biomarker of IL‐5 activity, is commonly used to evaluate the ...
Chiara Zecchin, Stein Schalkwijk, Isabelle J. Pouliquen, Alienor Berges, Nicholas Bird, Richard Follows, Daren Austin   +6 more
wiley   +1 more source