Results 81 to 90 of about 1,007,590 (275)

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Ectopic Dupuytren's disease in the wrist compressing the palmar cutaneous branch of the median nerve

JPRAS Open, 2018
A case report to describe the occurrence of Dupuytren's disease in the wrist leading to compression of the palmar cutaneous branch of the median nerve. A 60-year-old male presented with a lump on the volar aspect of the left wrist with reduced sensation ...
Matthew Fell, Kavan Johal, Norbert Kang
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Many peptides that are present in the external zone of the median eminence are not secreted into the hypophysial portal blood of sheep

, 1993
Apart from the well recognized factors that are produced by the hypothalamus and secreted into hypophysial portal blood to regulate pituitary function, there is a range of neuropeptides that are present in the median eminence and could be secreted to ...
Lew, R, Coen, C W; id_orcid, Millar, R, Bloom, S, Smith, I, Jessop, D, Clarke, I, Morris, M, Lightman, S   +8 more
core   +5 more sources

Orexin receptor-1 expression in adult rodent neurogenic regions: evidence from the subgranular zone and the median eminence

Annales Academiae Medicae Silesiensis
Introduction: Orexin signaling plays a vital role in regulating autonomic and cognitive functions, including sleep-wake cycles, feeding, and memory. Orexin receptor-1 (OX1R), a key component of this system, may also influence adult neurogenesis.
Antonello Pinna, Artur Pałasz
doaj   +1 more source

Microfluorimetric quantitation of catecholamine fluorescence in rat median eminence. II. Turnover changes in hormonal states.

, 1976
Catecholamine nerve terminals in the rat median eminence have been studied using the fluorescence histochemical technique of Falck and Hillarp in combination with quantitative microfluorimetry.
F A Wiesel, G Jonsson, A Löfström, K Fuxe   +3 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Adaptive oligodendrogenesis regulates blood-hypothalamus barrier permeability, hypothalamic glucose sensing and systemic glucose homeostasis in male mice

Molecular Metabolism
Objective: Brain glucose sensing is critical for survival during hypoglycaemia, yet how glucose-sensing neurons access circulating glucose concentrations to maintain glucose homeostasis remains poorly understood.
Sophie Buller, Emily O. Staricoff, Christine Riches, Anthony Tsang, Giada Giavara, Masa Josipovic, Kentaro Ikemura, Gabriel Opoku, Ikumi Sato, Satoshi Hirohata, Saskia Stenzel, Stuart G. Nayar, Marta Ramos Vega, Jacob Hecksher-Sørensen, Sebastian Timmler, Georgina K.C. Dowsett, Brian Y.H. Lam, Giles S.H. Yeo, Kimberly M. Alonge, Huiliang Li, William D. Richardson, Mark L. Evans, Clemence Blouet   +22 more
doaj   +1 more source

A method for drug infusion into the lateral median eminence and arcuate nucleus of sheep

, 1997
The role of catecholamines in the control of the GnRH pulse generator is unclear as studies have relied on the use of peripheral or intracerebroventricular injections, which lack specificity in relation to the anatomical site of action. Direct brain site
Sawangjaroen, K, J.D Curlewis, Anderson, ST, K Sawangjaroen, S.T Anderson, Curlewis, JD   +5 more
core   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source