Results 61 to 70 of about 1,007,590 (275)

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Dietary and sex-specific factors regulate hypothalamic neurogenesis in young adult mice.

Frontiers in Neuroscience, 2014
The hypothalamus is the central regulator of a broad range of homeostatic and instinctive physiological processes, such as the sleep-wake cycle, food intake, and sexually dimorphic behaviors.
Daniel eLee, Daniel eLee, Sooyeon eYoo, Thomas ePak, Juan eSalvatierra, Susan eAja, Esteban eVelarde, Esteban eVelarde, Seth eBlackshaw   +8 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source

ApoE-dependent lipid handling by median eminence microglia supports myelin remodeling and metabolic function

Cell Reports
Summary: Microglia regulate hypothalamic control of systemic metabolism, but the mechanisms underlying their contribution remain unclear. Here, we identify apolipoprotein E ( ApoE )-associated microglial transcriptional states enriched in the median ...
Emily R. McGrath, Andrew Folick, Luke J. Morrissette, Stephen M. Brown Mayfield, Hyehyun Kim, Li-Fang Weng, Vivian Pham, Sriya N. Pillutla, Moon Kyung Choi, Connor Tomaka, Annika N. Mechelke, Rachel T. Cheang, William R. Bolus, Anna Schwendeman, Vasilis Ntranos, Suneil K. Koliwad, Martin Valdearcos   +16 more
doaj   +1 more source

Median eminence

, 1997
Median eminence. Coronal plane.

core  

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Infundibular stalk median eminence

, 1997
Infundibular stalk median eminence. Hypothalamus, optic tract, fornix, supraoptic nucleus.

core  

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source

Compartmentalized VEGF receptor expression in hypothalamic tanycytes reveals a novel non-endothelial axis of VEGF signaling

Fluids and Barriers of the CNS
Background Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are critical regulators of angiogenesis and vascular homeostasis. While VEGF signaling has been extensively studied in endothelial cells, emerging evidence suggests it ...
Ombeline Desruelle, Manon Leclerc, Sreekala Nampoothiri, Daniela Fernandois, Claude-Alain Maurage, Markus Schwaninger, Vincent Prevot, Ines Martinez-Corral   +7 more
doaj   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source