Results 31 to 40 of about 59,578 (214)

Lethal Dose of Calcium Bentonite in Wistar Rats

Althea Medical Journal, 2021
Background: Calcium bentonite is a type of clay produced by a devitrification of volcanic ash which is often used as a traditional medicine to absorb toxins and waste products of metabolism.
Dwika Audiyananda, Hendro Sudjono Yuwono, Adria Adnan   +2 more
doaj   +1 more source

Evaluation of lethality and cytotoxic effects induced by Naja ashei (large brown spitting cobra) venom and the envenomation-neutralizing efficacy of selected commercial antivenoms in Kenya

Toxicon: X, 2022
Neutralization of lethality in mice model at the preclinical level has been established by the World Health Organization as the gold standard for the evaluation of antivenom efficacy.
Ernest Z. Manson, Mutinda C. Kyama, Joseph K. Gikunju, Josephine Kimani, James H. Kimotho   +4 more
doaj   +1 more source

Artificial Intelligence Calculation of Median Lethal Dose: A Word of Caution [PDF]

Asia Pacific Journal of Medical Toxicology
Traditional toxicity studies rely on laboratory animal experimentations to estimate the median lethal dose (LD50) of chemicals such as pesticides and medications.
Fouad Mohammad
doaj   +1 more source

Determination of Median Lethal (LD50) and Growth Reduction (GR50) Dose of Gamma Irradiation for Induced Mutation in Wheat [PDF]

Brazilian Archives of Biology and Technology, 2023
The determination of the optimum dose of radiation through its impacts on the growth attributes of the crop is the prerequisite for successful induced mutation breeding.
Sunanda Chakraborty, Sunita Mahapatra, Anubhab Hooi, Md Nasim Ali, Ramesh Satdive   +4 more
doaj   +1 more source

Toxicity effects of water extracts of H olothuria atra Jaeger in mice

Asian Pacific Journal of Tropical Biomedicine, 2014
Objective: To determine lethal median dose (LD50) and histopathological toxicity of water extract of Holothuria atra (H. atra) in mice. Methods: The behavioral changes, mortality and histopathology examination on liver were assessed in mice 14 d after ...
Ridzwan Bin Hashim, Nurul Alia Azizan, Zaitunnatakin Zamli, Farah Hanis Zulkipli, Nurzafirah Mazlan, Osama Yousef Althunibat   +5 more
doaj   +1 more source

Contact and Fumigant Activities of Citrus aurantium Essential Oil against the Stable Fly Stomoxys calcitrans (Diptera: Muscidae)

Plants, 2022
The stable fly, Stomoxys calcitrans (L.), is a cosmopolitan hematophagous fly of medical and veterinary importance. It is widely considered a major livestock pest that can cause significant economic losses.
Tanasak Changbunjong, Sookruetai Boonmasawai, Sivapong Sungpradit, Thekhawet Weluwanarak, Arpron Leesombun   +4 more
doaj   +1 more source

Evaluation of the Prophylactic Activity of Ethanolic Extract of Ricinus communis L. against Plasmodium berghei in Mice

UMYU Journal of Microbiology Research, 2019
The continuous quest to annihilate the scourge of malaria parasites and the need for exploration of new drugs for the ever-endemic killer disease opens the way for continued research.
Liadi, Y. M., Abdulhamid, A., Sulaiman, S. K., Umar, L.   +3 more
doaj   +1 more source

Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs

Toxicology Reports, 2021
Animal models are essential for evaluating the toxicity of chemical warfare nerve agents (CWNAs) to extrapolate to human risk and are necessary to evaluate the efficacy of medical countermeasures.
Lucille Lumley, Fu Du, Brenda Marrero-Rosado, Michael Stone, Zora-Maya Keith, Caroline Schultz, Kimberly Whitten, Katie Walker, Cindy Acon-Chen, Linnzi Wright, Tsung-Ming Shih   +10 more
doaj   +1 more source

Effects of Piper nigrum L. Fruit Essential Oil Toxicity against Stable Fly (Diptera: Muscidae)

Plants, 2023
The efficacy of Piper nigrum L. fruit essential oil (EO) against Stomoxys calcitrans (stable fly), a blood-feeding fly distributed worldwide, was investigated.
Thekhawet Weluwanarak, Tanasak Changbunjong, Arpron Leesombun, Sookruetai Boonmasawai, Sivapong Sungpradit   +4 more
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source