Results 41 to 50 of about 56,603 (238)
Acute toxicity of Nerium oleander aqueous leaf extract in rabbits [PDF]
Iraqi Journal of Veterinary Sciences, 2008 The median lethal dose was evaluated in rabbits subcutaneously injected with Nerium oleander aqueous leaf extract . The clinical signs , postmortem changes , hematological and biochemical changes were recorded. The results revealed that the median lethal
B. A. Al-Badrani +2 more
doaj +3 more sources
STUDY OF ACUTE TOXICITY OF DIFFERENT PREPARATION OF OLEANDER LEAVES IN MICE [PDF]
Basrah Journal of Veterinary Research, 2008 Three preparations of dried oleander leaves were prepared. The first one was by extraction with hexane; the second by extraction with 70% ethanol while the third was suspended as a whole ground leaves in distilled water.
Lubna A. Kafi +2 more
doaj +1 more source
YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma
Molecular Oncology, EarlyView.The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy +9 more
wiley +1 more source
Estimations of the lethal and exposure doses for representative methanol symptoms in humans
Annals of Occupational and Environmental Medicine, 2017 Background The aim of this review was to estimate the lethal and exposure doses of a representative symptom (blindness) of methanol exposure in humans by reviewing data from previous articles.
Chan-Seok Moon
doaj +1 more source
The Impact of Age and Sex on Mouse Models of Melioidosis
Pathogens, 2020 Mouse models have been used to generate critical data for many infectious diseases. In the case of Burkholderia pseudomallei, mouse models have been invaluable for bacterial pathogenesis studies as well as for testing novel medical countermeasures ...
Christopher P. Klimko +10 more
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Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
HeliyonGladiolus is a highly allogamous flower plant, but owing to the prolonged juvenile phase, asexual propagation is preferred, which acts as a barrier for the induction of natural genetic variability in gladiolus. Therefore, the induced mutagenesis could be
Anand Singh Rawat +9 more
doaj +1 more source
Female rats are less susceptible during puberty to the lethal effects of percutaneous exposure to VX
Toxicology Reports, 2016 Nerve agents with low volatility such as VX are primarily absorbed through the skin when released during combat or a terrorist attack. The barrier function of the stratum corneum may be compromised during certain stages of development, allowing VX to ...
Linnzi K.M. Wright +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
MethodsX, 2021 Current artemisinin-based combination therapy (ACT) regimen for the treatment of malaria is effective, but cases of malaria parasite's resistance to existing antimalarial drugs is worrisome.
Johnson Adejoh +2 more
doaj +1 more source