Results 61 to 70 of about 178,848,266 (217)

The Role Of Hmgb1-Related Inflammation Signals In Bronj

International Dental Journal
Aim or purpose: BRONJ causes prolonged inflammation, resulting in delayed wound healing. High mobility group box-1 (HMGB1) is secreted into the extracellular milieu in response to stimuli, which mediates various inflammatory diseases and affects wound ...
Li Shurong, Yan Jiayi
doaj   +1 more source

Bisphosphonates and Their Influence on the Implant Failure: A Systematic Review

Applied Sciences, 2023
Objective: The goal of this systematic review was to study the relationship between the use of bisphosphonates (oral or intravenous) and its effect on implant osseointegration. Methods: The focused question was “In patients medicated with bisphosphonates
Cristiana Gomes Rebelo, Juliana Campos Hasse Fernandes, Nuno Bernardo, Patrícia Couto, Gustavo Vicentis Oliveira Fernandes   +4 more
doaj   +1 more source

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Journal of Periodontal Research, EarlyView.
The scoping review summarizes the current preclinical and clinical evidence for the use of “cell‐free” therapies in craniofacial (periodontal, bone and soft‐tissue) regeneration. It also aims to highlight key challenges and strategies towards the clinical translation of these therapies.
Siddharth Shanbhag, Magdalena Mayol, Danijel Domic, Madhusudhan Reddy Bobbili, Johannes Grillari, Mariano Sanz, Reinhard Gruber   +6 more
wiley   +1 more source

Medication-Related Osteonecrosis of Jaw

ANNAL OF STOMATOLOGY
Medication-related osteonecrosis of the jaws (MRONJ) primarily occurs as a complication of bone antiresorptive treatment in specific bone treatment modalities. It was first identified in 2003 as a bisphosphonate (BP) treatment complication. Denosumab is a molecule with a particular mode of action.
Yue He, Hui Shan Ong, Zhen Tian, Lin Zhu, Hang Chen   +4 more
openaire   +2 more sources

Effect of Drug holiday in preventing the development of medication related osteonecrosis of the jaw (MRONJ)

, 2021
This systematic review and meta-analysis aims at assessing the effect of drug holiday (discontinuation) in preventing the development of medication-related osteonecrosis of the jaw (MRONJ) in patients receiving antiresorptive medications and are in need ...
Duaa Salem Almohammadi, Fazrina Farook, Ali Anwar aboalela, Rehab Alanazi, Mandlin Abdulaziz Almousa, Amerah Saeed Alqahtani   +5 more
core   +1 more source

Evaluation of Preventive Role of Systemically Applied Erythropoietin after Tooth Extraction in a Bisphosphonate-Induced MRONJ Model

Medicina, 2023
Background and Objectives: In this experimental study, the prophylactic effect of systemically administered erythropoietin (EPO) in medication-related osteonecrosis of the jaw (MRONJ) was evaluated.
Gonca Duygu, Gül Merve Yalcin-Ülker, Murat Günbatan, Merva Soluk-Tekkesin, Ceyda Özcakir-Tomruk   +4 more
doaj   +1 more source

Fibrous Dysplasia and Medication-Related Osteonecrosis of the Jaw [PDF]

Journal of Oral and Maxillofacial Surgery, 2016
Osteonecrosis of the jaw (ONJ) is an established side effect of intravenous bisphosphonates and other antiresorptive medications. Although bisphosphonates are frequently prescribed for patients with the skeletal disorder fibrous dysplasia (FD), there are no reports of ONJ in this population.
Tarek, Metwally, Andrea, Burke, Jeffrey Y, Tsai, Michael T, Collins, Alison M, Boyce   +4 more
openaire   +2 more sources

Cell Therapy for Periodontal, Soft‐Tissue, and Craniofacial Regeneration

Journal of Periodontal Research, EarlyView.
The clinical translation of mesenchymal stem/stromal cells (MSCs) represents a major advancement in dentistry, especially for periodontal, soft‐tissue, and craniofacial regeneration. However, several challenges remain to be addressed, including the absence of standardised protocols, limited scalability, regulatory hurdles, a lack of well‐controlled ...
Kamal Mustafa, Shuntaro Yamada, Nerea Sanchez, Magdalena Mayol, Cecilie Gjerde, Mariano Sanz   +5 more
wiley   +1 more source

Bone Grafts: Everything You Need to Know

Journal of Periodontal Research, EarlyView.
This review classifies bone grafts (autograft, allograft, xenograft, synthetic) by source and osteogenic/inductive/conductive potential, linking material properties and mechanisms to clinical indications in periodontal and dental regeneration. Key challenges—limited osteoinduction, poor vascularisation, unbalanced resorption, handling difficulties, and
Håvard Jostein Haugen, Javier Sanz, Giuseppe Perale, Augustine Mark Saiz, Mario Romandini, Maryam Rahmati   +5 more
wiley   +1 more source

Treatment of Medication-Related Osteonecrosis of the Jaw

, 2023
Medication-related osteonecrosis of the jaw (MRONJ) is a most interesting, complex and elusive condition seen by the oral health care provider. It is plagued by controversy and although a wealth of research has created clinical treatment databases ...
Adams, David Russell, David Russell Adams, Halpern, Leslie Robin, Leslie Robin Halpern   +3 more
core   +1 more source