Results 1 to 10 of about 8,365 (219)

Mediterranean fever gene variants may prevent the development of lupus nephritis in Japanese patients with systemic lupus erythematosus [PDF]

Frontiers in Immunology
BackgroundSystemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of immune tolerance, leading to systemic inflammation and organ damage. The Mediterranean fever (MEFV) gene, primarily linked to familial Mediterranean fever (FMF)
Yushiro Endo, Tomohiro Koga, Lamiaa Mohamed, Yoshika Tsuji, Masataka Umeda, Hiroko Hayashi, Tatsuya Kishino, Atsushi Kawakami   +7 more
doaj   +2 more sources

Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis [PDF]

PLoS Genetics, 2019
Ankylosing spondylitis (AS) is a highly heritable immune-mediated arthritis common in Turkish and Iranian populations. Familial Mediterranean Fever (FMF) is an autosomal recessive autoinflammatory disease most common in people of Mediterranean origin ...
Zhixiu Li, Servet Akar, Gerçek Can
exaly   +2 more sources

Impact of Mediterranean Fever Gene Mutations on Clinical Characteristics in Patients With Inflammatory Bowel Disease [PDF]

Gastro Hep Advances
Background and Aims: The Mediterranean fever (MEFV) gene, which encodes a pyrin protein, is the causative gene of familial Mediterranean fever. Patients with inflammatory bowel disease (IBD) have a significantly higher frequency of MEFV mutations than ...
Tomoya Nakamura, Kohei Wagatsuma, Yuki Hayashi, Hiromu Morikubo, Daisuke Saito, Masashi Idogawa, Masanori Nojima, Jun Miyoshi, Minoru Matsuura, Tadakazu Hisamatsu, Hiroshi Nakase   +10 more
doaj   +2 more sources

Identification of pathogenic MEFV variants in Korean patients with familial Mediterranean fever via whole-genome sequencing: a case report [PDF]

Journal of Rheumatic Diseases
Familial Mediterranean fever (FMF) is an autoinflammatory disorder characterized by recurrent episodes of fever, serositis, and arthritis. It is caused by variants in the MEFV gene, which encodes the pyrin protein.
Se Rim Choi, Christopher J. Yoon, Jeong Seok Lee, Young Seok Ju, Eun Young Lee   +4 more
doaj   +2 more sources

Updates on the molecular spectrum of MEFV variants in lebanese patients with Familial Mediterranean Fever [PDF]

Frontiers in Genetics
Familial Mediterranean Fever (FMF) is a hereditary autoinflammatory disorder, particularly present in the Mediterranean populations, and associated with pathogenic variants in the MEFV gene.
Rudy Feghali, José-Noel Ibrahim, Nabiha Salem, Romy Moussallem, Ghina Hijazi, Charbel Attieh, Tony Yammine, Alain Chebly, Alain Chebly   +8 more
doaj   +2 more sources

An association between MEFV mutation and ANCA-associated vasculitis involving the central nervous system and lungs: causality under scrutiny [PDF]

European Journal of Case Reports in Internal Medicine
Familial Mediterranean fever (FMF) is traditionally associated with biallelic mutations in the MEFV gene; however, heterozygous mutations may also contribute to disease phenotypes.
Marcus Villander Barros de Oliveira Sá, Amanda Brito, Miriam Baié, Flávio Pacheco, Luydson Vasconcelos   +4 more
doaj   +2 more sources

Dimethylaminoparthenolide (DMAPT) as an alternative approach for treatment of Familial Mediterranean Fever (FMF) [PDF]

Iranian Journal of Basic Medical Sciences, 2021
Objective(s): Familial Mediterranean Fever (FMF) is a hereditary auto-inflammatory disorder that is caused by mutations in the Mediterranean fever (MEFV) gene and is associated with an increase in pro-inflammatory cytokines, such as interleukin-1β (IL-1β)
Ali Mosayebian, Roya Sherkat, Saeid Abediankenari, Monireh Golpour, Alireza Rafiei   +4 more
doaj   +1 more source

Evaluation of Clinical, Genetic and Treatment-Related Characteristics in FMF Patients by Gender Distribution

Turkish Journal of Internal Medicine, 2021
The aim of this study is to investigate the differences between males and females in clinical findings, hereditary characteristics, treatment responses and pathogen Mediterranean fever (MEFV) gene phenotype frequencies in FMF patients.
Ayten Dinar, Koray Ayar
doaj   +1 more source

Analysis of the mutations in exon 10 of MEFV gene in patients with premature coronary heart disease in west Azerbaijan province of Iran [PDF]

Journal of Cardiovascular and Thoracic Research, 2018
Introduction: Premature coronary heart disease (PCHD) affects public health and leads to death. PCHD has several genetic and environmental risk factors. The aim of this study was to analysis of the mutations in exon 10 of MEFV gene in patients with PCHD ...
Morteza Bagheri, Kamal Khadem-Vatani, Mir Hossein Seyed Mohammad Zad, Isa Abdi Rad, Behzad Rahimi, Alireza Rostamzadeh, Mojtaba Godarzi, Shabnam Ashena   +7 more
doaj   +1 more source

Scrotal involvement in childhood immunoglobulin A associated vasculitis

Journal of Contemporary Medicine, 2021
Aim: The aim of this study is to evaluate the demographic and clinic findings in immunoglobulin A-associated vasculitis (IgAV) patients with scrotal involvement and also to determine predictive factors for assessing the development of scrotal involvement.
Cüneyt Karagöl, Serkan Coşkun, Tuba Kurt, Elif Çelikel, Fatma Aydın, Zahide Ekici Tekin, Nilüfer Tekgöz, Müge Sezer, Melike Kaplan, Banu Acar   +9 more
doaj   +1 more source