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Megakaryocyte and polyploidization
Experimental Hematology, 2018In mammals, platelets are produced in the blood by cytoplasmic fragmentation of megakaryocytes (MKs). Platelet production is thus dependent on both the MK number and size. During differentiation, MKs switch from a division by mitosis to polyploidization by endomitosis to increase their size. The endomitotic process includes several successive rounds of
Stefania, Mazzi +4 more
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Histopathology, 1982
Cells resembling the smaller variants of the Warthin‐Finkeldey giant cells of measles were observed in the pulmonary alveolar capillaries in a high percentage of primates and humans apparently free from pathological changes associated with measles. Cells resembling megakaryocytes were found also in the liver and spleen in both groups but only in a ...
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Cells resembling the smaller variants of the Warthin‐Finkeldey giant cells of measles were observed in the pulmonary alveolar capillaries in a high percentage of primates and humans apparently free from pathological changes associated with measles. Cells resembling megakaryocytes were found also in the liver and spleen in both groups but only in a ...
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Archives of Internal Medicine, 1948
THERE have been many observations in medical literature in which megakaryocytes have been described as a prominent feature in pathologic conditions of the blood. The number of these cells is frequently increased in thrombocytothemia and polycythemia vera.
J B, McDONALD, J G, HAMRICK
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THERE have been many observations in medical literature in which megakaryocytes have been described as a prominent feature in pathologic conditions of the blood. The number of these cells is frequently increased in thrombocytothemia and polycythemia vera.
J B, McDONALD, J G, HAMRICK
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Megakaryocytes and Megakaryocyte Progenitors in Human Cord Blood
Journal of Pediatric Hematology/Oncology, 1992Thrombocytopenia contributes significantly to morbidity in the sick term or preterm infant. However, few data exist on newborn's megakaryocytes and megakaryocyte progenitor cells (CFU-MK). We therefore studied CFU-MK in term and preterm infant cord blood and compared the results with data on CFU-MK from adult bone marrow and adult peripheral blood in a
T A, Olson +4 more
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Blood, 2010
In this issue of Blood, Halene and colleagues reveal an essential function of the transcription factor SRF during megakaryocyte maturation and platelet formation. The spectrum of SRF-regulated genes overlaps with SRF targets in muscle cells, including those involved in actin cytoskeletal dynamics.
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In this issue of Blood, Halene and colleagues reveal an essential function of the transcription factor SRF during megakaryocyte maturation and platelet formation. The spectrum of SRF-regulated genes overlaps with SRF targets in muscle cells, including those involved in actin cytoskeletal dynamics.
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Journal of Cellular Physiology, 1982
AbstractAn assay describing conditions for the maturation of single immature megakaryocytes in vitro is reported. Enriched populations of small, relatively immature megakaryocytes have been found to develop into single, mature megakaryocytes by 60 hours in semisolid agar cultures.
Long, M W, Williams, N, Mcdonald, T P
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AbstractAn assay describing conditions for the maturation of single immature megakaryocytes in vitro is reported. Enriched populations of small, relatively immature megakaryocytes have been found to develop into single, mature megakaryocytes by 60 hours in semisolid agar cultures.
Long, M W, Williams, N, Mcdonald, T P
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2001
Abstract Megakaryocytopoiesis is the process by which pluripotent bone marrow progenitors develop into mature megakaryocytes, which then spawn functional platelets. Circulating platelets perform a vital function in the maintenance of hemostasis in the peripheral blood vasculature.
Daniel J Price +2 more
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Abstract Megakaryocytopoiesis is the process by which pluripotent bone marrow progenitors develop into mature megakaryocytes, which then spawn functional platelets. Circulating platelets perform a vital function in the maintenance of hemostasis in the peripheral blood vasculature.
Daniel J Price +2 more
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Megakaryocyte-Bone Cell Interactions
2009Emerging data show that megakaryocytes (MKs) play a role in the replication and development of bone cells. Both in vivo and in vitro evidence now show that MKs can have significant effects on cells of the osteoclast (OC) and osteoblast (OB) lineage, with obvious manifestations on bone phenotype, and probable significance for human pathology.There are ...
Melissa A, Kacena, Wendy A, Ciovacco
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[Megakaryocytic leukemia cell lines and megakaryocytic leukemia].
Rinsho byori. The Japanese journal of clinical pathology, 1990Using the megakaryocytic leukemia cell lines, K-562 and CMK established from a Down's patient with acute megakaryoblastic leukemia, we studied the changes of antigen expression, cytosolic Ca2+ mobilization, thromboxane (TX) A2 formation and gene expression during megakaryocyte differentiation. We found that thrombospondin synthesis and platelet factor (
R, Ryo, A, Yoshida, N, Yamaguchi
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Thrombosis and Haemostasis, 1981
The size range of megakaryocytes (megas) is widely given as 30-100 μm; however, extensive direct data are lacking. Large numbers of guinea pig (gp) and human megas have been examined at 1000X by phase contrast microscopy with an eyepiece micrometer. In a suspension of gp bone marrow cells megas had an average diameter of 26.0±10.2 (SD) ym with a range ...
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The size range of megakaryocytes (megas) is widely given as 30-100 μm; however, extensive direct data are lacking. Large numbers of guinea pig (gp) and human megas have been examined at 1000X by phase contrast microscopy with an eyepiece micrometer. In a suspension of gp bone marrow cells megas had an average diameter of 26.0±10.2 (SD) ym with a range ...
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