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Journal of Lipid Research, 1990 The composition and synthesis of megakaryocyte and platelet glycolipids were compared since these lipids are thought to be important for biologic activities such as adhesion and maturation. Highly purified guinea pig megakaryocytes at different stages of
PK Schick, XL He
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Megakaryocyte- and megakaryocyte precursor–related gene therapies [PDF]
Blood, 2016 AbstractHematopoietic stem cells (HSCs) can be safely collected from the body, genetically modified, and re-infused into a patient with the goal to express the transgene product for an individual’s lifetime. Hematologic defects that can be corrected with an allogeneic bone marrow transplant can theoretically also be treated with gene replacement ...
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Culture of Megakaryocytes from Human Peripheral Blood Mononuclear Cells
Bio-Protocol, 2015 Megakaryocytes are the precursor cells of platelets and are bona fide resident cells in the bone marrow but extremely low in numbers (~1% of total nucleated cells).
Vishal Salunkhe +2 more
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Macedonian Veterinary Review, 2019 Emperipolesis is considered a physiological phenomena often present in various pathophysiological conditions, but its etiology is still unknown. In this study, we analyzed the number of megakaryocytes and the percentage of emperipoletic cells in the ...
Damir Suljević +2 more
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Studies on reticuloendothelial system and hemaotpoiesis. I. Studies of extramedullary hematopoiesis [PDF]
, 1965 The author studied the hematopoietic disturbances of rabbit induced by saponin injection and drew the following conclusions: 1) By saponin injection, the structure of bone marrow is disintegrated and hematopoietic cells are released into the circulating ...
Matsuoka, Kenichi
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CLEC-2 and Syk in the megakaryocytic/platelet lineage are essential for development [PDF]
, 2011 The C-type lectin receptor CLEC-2 signals through a pathway that is critically dependent on the tyrosine kinase Syk. We show that homozygous loss of either protein results in defects in brain vascular and lymphatic development, lung inflation and ...
Abramoff +66 more
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CD45 expression discriminates waves of embryonic megakaryocytes in the mouse
Haematologica, 2019 Embryonic megakaryopoiesis starts in the yolk sac on gestational day 7.5 as part of the primitive wave of hematopoiesis, and it continues in the fetal liver when this organ is colonized by hematopoietic progenitors between day 9.5 and 10.5, as the ...
Isabel Cortegano +9 more
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CD34+ megakaryocytes and megakaryocytic fragments in myelodysplastic syndrome [PDF]
Blood, 2017 ![Figure][1] A 65-year-old woman presented with fatigue and exertional dyspnea. The peripheral blood showed: hemoglobin, 91 g/L; leukocytes, 4.8 × 109/L with 1% blast cells; and platelets, 35 × 109/L with megakaryocytic fragments (panel A, filled black arrow; original magnification ×100;
Yan, Chen, Hong, Chang
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From human Megakaryocytes to platelets: Effects of aspirin on high-mobility group Box 1/receptor for advanced glycation end products axis [PDF]
, 2018 Platelets (PLTs) are the major source of high-mobility group box 1 (HMGB1), a protein that is involved in sterile inflammation of blood vessels and thrombosis.
Alessandra Zicari +9 more
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Dual role of IL-21 in megakaryopoiesis and platelet homeostasis
Haematologica, 2017 Gene profiling studies have indicated that in vitro differentiated human megakaryocytes express the receptor for IL-21 (IL-21R), an immunostimulatory cytokine associated with inflammatory disorders and currently under evaluation in cancer therapy.
Salima Benbarche +7 more
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