Results 1 to 10 of about 8,227 (218)

M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity

Signal Transduction and Targeted Therapy, 2021
Dysfunctional megakaryopoiesis hampers platelet production, which is closely associated with thrombocytopenia (PT). Macrophages (MФs) are crucial cellular components in the bone marrow (BM) microenvironment.
Hong-Yan Zhao, Meng Lv, Lan-Ping Xu
exaly   +2 more sources

Epigenetic regulation of megakaryopoiesis and platelet formation [PDF]

Haematologica
Platelets, produced by megakaryocytes, play unique roles in physiological processes, such as hemostasis, coagulation, and immune regulation, while also contributing to various clinical diseases.
Baichuan Xu, Xianpeng Ye, Zhaoyang Wen, Shilei Chen, Junping Wang   +4 more
doaj   +4 more sources

TFII-I/Gtf2i and Erythro-Megakaryopoiesis [PDF]

Frontiers in Physiology, 2020
TFII-I is a ubiquitously expressed transcription factor that positively or negatively regulates gene expression. TFII-I has been implicated in neuronal and immunologic diseases as well as in thymic epithelial cancer.
Aishwarya Gurumurthy, Qiong Wu, Rukiye Nar, Kimberly Paulsen, Alexis Trumbull, Ryan C. Fishman, Marjorie Brand, John Strouboulis, Zhijian Qian, Jörg Bungert   +9 more
doaj   +4 more sources

Excessive serine from the bone marrow microenvironment impairs megakaryopoiesis and thrombopoiesis in Multiple Myeloma

Nature Communications, 2023
Thrombocytopenia is a major complication in a subset of patients with multiple myeloma (MM). However, little is known about its development and significance during MM. Here, we show thrombocytopenia is linked to poor prognosis in MM.
Zhenhao Liu, Jian Li, Lugui Qiu
exaly   +2 more sources

Heterozygous nonsense FLI1 p.Met100∗ variant results in thrombocytopenia and increased erythroid gene expression [PDF]

Research and Practice in Thrombosis and Haemostasis
Background: Megakaryocytes and platelets arise from hematopoietic stem and progenitor cells through a tightly regulated process involving various transcription factors, including erythroblast transformation–specific family member FLI1.
Huan Zhang, Elise J. Huisman, Roel van Rhijn, Arthur F. Svendsen, Hans Janssen, Nicole van der Wel, Carmen van der Zwaan, Nynke Gillemans, Wilfred F.J. van IJcken, Marten Hansen, Marjon H. Cnossen, Sjaak Philipsen, Arie J. Hoogendijk, Emile van den Akker, Martijn Brands, Sjoerd Koopman, Laura Bukkems, Michael Cloesmeijer, Alexander Janssen, Karin Fijnvandraat, Samantha Gouw, Ron Mathôt, Maartje van den Biggelaar, Sander Meijer, Jan Voorberg, Jessica Del Castillo Alferez, Karina Meijer, Jeroen Eikenboom, Sebastiaan Laan, Ruben Bierings, Marjon Cnossen, Masja de Haas, Frank Leebeek, Hester Lingsma, Moniek de Maat, Iris van Moort, Simone Reitsma, Ryanne Arisz, Lorenzo Romano, Wala Al Arashi, Shannon van Hoorn, Tine Goedhart, Caroline Mussert, Diaz Prameyllawati, Rolf Urbanus, Minka Zivkovic, Annelien Bredenoord, Rieke van der Graaf, Lieke Baas, Roger Schutgens   +49 more
doaj   +2 more sources

Megakaryopoiesis [PDF]

Seminars in Hematology, 2010
The process of megakaryopoiesis and platelet production is complex, with the potential for regulation at multiple stages. Megakaryocytes are derived from the hematopoietic stem cell through successive lineage commitment steps, and they undergo a unique maturation process that includes polyploidization, development of an extensive internal demarcation ...
exaly   +3 more sources

Thrombocytopenia in dengue infection: mechanisms and a potential application [PDF]

Expert Reviews in Molecular Medicine
Thrombocytopenia is a common symptom and one of the warning signs of dengue virus (DENV) infection. Platelet depletion is critical as it may lead to other severe dengue symptoms.
Ahmad Suhail Khazali, Waqiyuddin Hilmi Hadrawi, Fatimah Ibrahim, Shatrah Othman, Nurshamimi Nor Rashid   +4 more
doaj   +2 more sources

Induction of moderate DNA damage enhances megakaryopoiesis and platelet production [PDF]

Blood Advances
: Megakaryocytes (MKs) are large, hematopoietic cells with a polyploid, multilobulated nucleus. Although DNA replication in MKs (endomitosis) is well studied, limited investigations have examined the impact of DNA instability on megakaryopoiesis.
Virginia Camacho, Roelof H. Bekendam, Andrew P. Stone, Maria N. Barrachina, Siobhan Branfield, Estelle Carminita, Isabelle C. Becker, Dong H. Lee, Ethan Walsey, Clementine Payne, Jakub Kaplan, Julia Tilburg, Sharmistha Pal, Luis Francisco Zirnberger Batista, Joseph E. Italiano, Jr., Kellie R. Machlus   +15 more
doaj   +2 more sources

The Hippo-p53 pathway in megakaryopoiesis

Haematologica, 2016
Megakaryocytes are among the largest and rarest cells in the body, accounting for approximately 0.01% of nucleated cells in the bone marrow. Their differentiation involves a progression from hematopoietic stem cell to the megakaryocyte progenitor and finally to platelets.[1][1] A key step in ...
Praveen K Suraneni, John D. Crispino
doaj   +3 more sources

Eltrombopag, a potent stimulator of megakaryopoiesis

Haematologica, 2016
In this issue of Haematologica , Di Buduo et al. show that eltrombopag induces human megakaryopoiesis in vitro and ex vivo through an activation of STAT, AKT and ERK pathways that is different from the other thrombomimetic, romiplostim.[1][1] Megakaryopoiesis is the process leading to ...
Hana Raslova, William Vainchenker, Isabelle Plo   +2 more
doaj   +3 more sources