Results 31 to 40 of about 8,227 (218)

Survival Motor Neuron (SMN) protein is required for normal mouse liver development [PDF]

, 2016
Spinal Muscular Atrophy (SMA) is caused by mutation or deletion of the survival motor neuron 1 (SMN1) gene. Decreased levels of, cell-ubiquitous, SMN protein is associated with a range of systemic pathologies reported in severe patients.
Francesco, M, Gillingwater, TH, Maxwell, GK, Parson, SH, Powis, RA, Szunyogova, E, Zhou, H   +6 more
core   +5 more sources

The Involvement of Canonical NFκB Pathway in Megakaryocyte Differentiation Induction by Nanocurcumin

International Journal of Hematology-Oncology and Stem Cell Research, 2023
Background: Megakaryopoiesis is characterized by progressive polyploidization and the expression of megakaryocytic markers. Numerous transcription factors and physiological signaling pathways regulate this phenomenon.
Seyedeh Sahar Mortazavi Farsani, Dina Sadeghizadeh, Sadegh Babashah, Fariba Rad, Majid Sadeghizadeh   +4 more
doaj   +1 more source

miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis

eLife, 2014
Genome-encoded microRNAs (miRNAs) provide a posttranscriptional regulatory layer that controls the differentiation and function of various cellular systems, including hematopoietic cells. miR-142 is one of the most prevalently expressed miRNAs within the
Elik Chapnik, Natalia Rivkin, Alexander Mildner, Gilad Beck, Ronit Pasvolsky, Eyal Metzl-Raz, Yehudit Birger, Gail Amir, Itay Tirosh, Ziv Porat, Liron L Israel, Emmanuel Lellouche, Shulamit Michaeli, Jean-Paul M Lellouche, Shai Izraeli, Steffen Jung, Eran Hornstein   +16 more
doaj   +1 more source

In vitro effect of eltrombopag alone and in combination with azacitidine on megakaryopoiesis in patients with myelodysplastic syndrome

Platelets, 2021
Thrombocytopenia is a severe complication for patients with myelodysplastic syndrome (MDS). Eltrombopag increases platelet count in MDS patients but its combination with azacitidine elicited controversial results.
Francesco D’Alò, Ilaria Zangrilli, Elisa Cupelli, Luana Fianchi, Marianna Criscuolo, Giulia Falconi, Emiliano Fabiani, Livio Pagano, Stefan Hohaus, Valerio De Stefano   +9 more
doaj   +1 more source

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies [PDF]

, 2016
The Src family kinase (SFK)member SRC is amajor target in drug development because it is activated in many human cancers, yet deleterious SRC germline mutations have not been reported. We used genome sequencing and Human Phenotype Ontology patient coding
,, Ashford, Sofie, Attwood, Antony, Austin, Steve, Bakchoul, Tamam, Bariana, Tadbir K, Bradley, John R, Collins, Peter, De Maeyer, Marc, Deevi, Sri V V, Erber, Wendy N, Favier, Rémi, Freson, Kathleen, Gomez, Keith, Greene, Daniel, Kelly, Anne M, Kostadima, Myrto, Laffan, Michael A, Lambert, Michele P, Lentaigne, Claire, Lucy Raymond, F, Mathias, Mary, Millar, Carolyn M, Mumford, Andrew D, Nurden, Paquita, Ouwehand, Willem H, Papadia, Sofia, Peerlinck, Kathelijne, Penkett, Christopher J, Perry, David J, Rendon, Augusto, Richardson, Sylvia, Schulman, Sol, Selleslag, Dominik, Simeoni, Ilenia, Stephens, Jonathan C, Stirrups, Kathleen, Thys, Chantal, Turro, Ernest, Van Geet, Chris, Westbury, Sarah K, Whitehorn, Deborah, Wijgaerts, Anouck, Wittevrongel, Christine   +43 more
core   +2 more sources

A novel method for automated assessment of megakaryocyte differentiation and proplatelet formation

Platelets, 2018
Transfusion of platelet concentrates represents an important treatment for various bleeding complications. However, the short half-life and frequent contaminations with bacteria restrict the availability of platelet concentrates and raise a clear demand ...
M. Salzmann, B. Hoesel, M. Haase, M. Mussbacher, WC. Schrottmaier, JB. Kral-Pointner, M. Finsterbusch, A. Mazharian, A. Assinger, JA. Schmid   +9 more
doaj   +1 more source

Donor hematopoietic progenitor cells in nonmyeloablated rat recipients of allogeneic bone marrow and liver grafts [PDF]

, 1999
Background. Although the persistence of multilineage microchimerism in recipients of long-surviving organ transplants implies engraftment of migratory pluripotent donor stem cells, the ultimate localization in the recipient of these cells has not been ...
Demetris, AJ, Lu, L, Murase, N, Sakamoto, T, Starzl, TE, Ye, Q   +5 more
core   +1 more source

miRNA-mRNA integrative analysis in primary myelofibrosis CD34+ cells: role of miR-155/JARID2 axis in abnormal megakaryopoiesis [PDF]

, 2014
Primary myelofibrosis (PMF) is a myeloproliferative neoplasm characterized by megakaryocyte (MK) hyperplasia, bone marrow fibrosis, and abnormal stem cell trafficking. PMF may be associated with somatic mutations in JAK2, MPL, or CALR.
Associazione Italiana per la Ricerca sul Cancro Gruppo Italiano Malattie Mieloproliferative, Investigators, Barosi, Giovanni, Bianchi, Elisa, Bisognin, Andrea, Bogani, Costanza, Bortoluzzi, Stefania, Cazzola, Mario, Fanelli, Tiziana, Ferrari, Sergio, Guglielmelli, Paola, Manfredini, Rossella, Mannarelli, Carmela, Norfo, Ruggiero, Pennucci, Valentina, Pietra, Daniela, Prudente, Zelia, Rambaldi, Alessandro, Rontauroli, Sebastiano, Rosti, Vittorio, Ruberti, Samantha, Sacchi, Giorgia, Salati, Simona, Salmoiraghi, Silvia, Tagliafico, Enrico, Vannucchi, Alessandro M, Zini, Roberta   +25 more
core   +1 more source

Mercury Chloride Impacts on the Development of Erythrocytes and Megakaryocytes in Mice

Toxics, 2021
Inorganic mercury (Hg2+) is a highly toxic heavy metal. The aim of this study was to investigate the impact of Hg2+ on the development of erythrocytes and megakaryocytes.
Jinyi He, Yifan Zhao, Tingting Zhu, Peng Xue, Weiwei Zheng, Ye Yao, Weidong Qu, Xiaodong Jia, Rongzhu Lu, Miao He, Yubin Zhang   +10 more
doaj   +1 more source

MEIS1 Regulates Hemogenic Endothelial Generation, Megakaryopoiesis, and Thrombopoiesis in Human Pluripotent Stem Cells by Targeting TAL1 and FLI1

Stem Cell Reports, 2018
Summary: Human pluripotent stem cells (hPSCs) provide an unlimited source for generating various kinds of functional blood cells. However, efficient strategies for generating large-scale functional blood cells from hPSCs are still lacking, and the ...
Hongtao Wang, Cuicui Liu, Xin Liu, Mengge Wang, Dan Wu, Jie Gao, Pei Su, Tatsutoshi Nakahata, Wen Zhou, Yuanfu Xu, Lihong Shi, Feng Ma, Jiaxi Zhou   +12 more
doaj   +1 more source