Results 41 to 50 of about 8,227 (218)

Can we continue research in splenectomized dogs? Mycoplasma haemocanis: Old problem - New insight [PDF]

, 2004
We report the appearance of a Mycoplasma haemocanis infection in laboratory dogs, which has been reported previously, yet, never before in Europe. Outbreak of the disease was triggered by a splenectomy intended to prepare the dogs for a hemorrhagic shock
A. Schropp, Benjamin MM, Berent LM, Birkenheuer A, Brinson J, Brodey RS, C. Wojtczyk, Crowell JW, Davies BN, Donovan EF, Dunham CM, E. Thein, F. Meisner, G. Enders, G. Kemming, Gretillat S, H. Kisch-Wedel, Hartwig G, Hoskins JD, J.B. Messick, K. Messmer, K. Packert, Krakowka S, Lester SL, Messick JB, Pryor, S. Muenzing, Seneviratna P, Venable JH, W. Mueller, Walcott WW, West HJ, Wiggers CJ, Withrington PG, Wright IG, Zweifach BW   +35 more
core   +1 more source

Novel function of FAXDC2 in megakaryopoiesis [PDF]

Blood Cancer Journal, 2016
AbstractFAXDC2 (fatty acid hydroxylase domain containing 2) is a member of the fatty acid hydroxylase superfamily. Given the important role of fatty acids in megakaryocytes, we have studied the role of this gene in the development of this lineage. Here we show that the expression of FAXDC2 is constantly elevated during megakaryocyte maturation.
Jin, Q, Ren, Y, Wang, M, Suraneni, P K, Li, D, Crispino, J D, Fan, J, Huang, Z   +7 more
openaire   +2 more sources

Evidence for a role of TRIB3 in the regulation of megakaryocytopoiesis [PDF]

, 2017
Megakaryocytopoiesis is a complex differentiation process driven by the hormone thrombopoietin by which haematopoietic progenitor cells give rise to megakaryocytes, the giant bone marrow cells that in turn break down to form blood platelets.
A Hart, AP Tsang, CA Graaf de, D Ord, E Bianchi, E Kiss-Toth, F Goncalves, G Wang, IS Hitchcock, J Boudeau, K Du, K Eto, L Pang, L Qi, L Roy, M Ahluwalia, M Ahluwalia, MC Chan, MC Rouyez, N Ohoka, O Bezy, RA Shivdasani, RA Shivdasani, S Fichelson, S Kato, S Severin, Y Hong, Y Takahashi, Z Hegedus   +28 more
core   +2 more sources

PI3K/HSCB axis facilitates FOG1 nuclear translocation to promote erythropoiesis and megakaryopoiesis

eLife
Erythropoiesis and megakaryopoiesis are stringently regulated by signaling pathways. However, the precise molecular mechanisms through which signaling pathways regulate key transcription factors controlling erythropoiesis and megakaryopoiesis remain ...
Gang Liu, Yunxuan Hou, Xin Jin, Yixue Zhang, Chaoyue Sun, Chengquan Huang, Yujie Ren, Jianmin Gao, Xiuli Wang, Xiumei Jiang   +9 more
doaj   +1 more source

Annexin V and CXCR4 Expression in Adult Immune Thrombocytopenia. Control Randomized Study [PDF]

Journal of Bioscience and Applied Research, 2018
Background: Annexin V is a cellular protein used to detect apoptotic cells by its ability to bind to phosphatidylserine, a marker of apoptosis when it is on the outer leaflet of the plasma membrane.CXCR4 is expressed on cells of megakaryocytic series ...
Rania fawzy, Amal Nasr, Noha El Husseiny, Mona Gamil, Heba El Demellawy, Hend Hassan, Ibrahim Ibrahim   +6 more
doaj   +1 more source

Thrombopoietic effect of VPAC1 inhibition during megakaryopoiesis [PDF]

British Journal of Haematology, 2010
SummaryMegakaryocytes and platelets express the stimulatory G protein (Gs)‐coupled VPAC1 receptor, for which the pituitary adenylyl cyclase‐activating peptide (PACAP) and vasoactive intestinal peptide (VIP) are agonists. The neuropeptide PACAP and VPAC1 were previously found to negatively regulate megakaryopoiesis, and inhibition of their physiological
Peeters, Karen, Loyen, Serena, van Kerckhoven, Soetkin, Stoffels, Katinka, Hoylaerts, Marc F, van Geet, Christel, Freson, Kathleen   +6 more
openaire   +3 more sources

Transcriptional diversity during lineage commitment of human blood progenitors. [PDF]

, 2014
Blood cells derive from hematopoietic stem cells through stepwise fating events. To characterize gene expression programs driving lineage choice, we sequenced RNA from eight primary human hematopoietic progenitor populations representing the major ...
Astle, William J, Attwood, Antony, Bariana, Tadbir, Bertone, Paul, Bielczyk-Maczynska, Ewa, Breschi, Alessandra, Burden, Frances, Canu, Giovanni, Chambers, John C, Chen, Lu, Choudry, Fizzah A, Clarke, Laura, Coe, Sophia, Consortium, Bridge, Coupland, Paul, Cvejic, Ana, de Bono, Bernard, Downes, Kate, Erber, Wendy N, Farrow, Samantha, Favier, Rémi, Fenech, Matthew E, Flicek, Paul, Foad, Nicola, Freson, Kathleen, Frontini, Mattia, Garcia, Sara P, Goldman, Nick, Gomez, Keith, Guigo, Roderic, Hampshire, Daniel, Jansen, Joop H, Jansen, Sjoert BG, Kelly, Anne M, Kerstens, Hindrik HD, Kooner, Jaspal S, Kostadima, Myrto, Labalette, Charlotte, Laffan, Michael, Lentaigne, Claire, Loos, Remco, Macaulay, Iain C, Martens, Joost HA, Martin, Tiphaine, Meacham, Stuart, Mumford, Andrew, Nürnberg, Sylvia, Ouwehand, Willem H, Palumbo, Emilio, Poudel, Pawan, Read, Randy J, Rendon, Augusto, Richardson, David, Richardson, Sylvia, Sammut, Stephen J, Slodkowicz, Greg, Soranzo, Nicole, Stunnenberg, Hendrik G, Tamuri, Asif U, Turro, Ernest, van der Ent, Martijn, van der Reijden, Bert A, van Geet, Chris, Vasquez, Louella, Voss, Katrin, Watt, Stephen, Westbury, Sarah   +66 more
core   +1 more source

Interplay between FLI-1 and the LDB1 complex in murine erythroleukemia cells and during megakaryopoiesis

iScience, 2021
Summary: Transcription factors are key players in a broad range of cellular processes such as cell-fate decision. Understanding how they act to control these processes is of critical importance for therapy purposes.
Guillaume Giraud, Petros Kolovos, Ilias Boltsis, Jente van Staalduinen, Boris Guyot, Michele Weiss-Gayet, Wilfred van IJcken, François Morlé, Frank Grosveld   +8 more
doaj   +1 more source

Foxp3 Regulates Megakaryopoiesis and Platelet Function [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2009
Objective— Platelets are crucial for hemostasis and are vital regulators of inflammation. Foxp3 is a key transcription factor for T regulatory cell development. Humans with IPEX (immune dysregulation, polyendocrinopathy, enteropathy, x-linked) and the scurfy (
Jamie J, Bernard, Kathryn E, Seweryniak, Anne D, Koniski, Sherry L, Spinelli, Neil, Blumberg, Charles W, Francis, Mark B, Taubman, James, Palis, Richard P, Phipps   +8 more
openaire   +2 more sources

A novel signalling screen demonstrates that CALR mutations activate essential MAPK signalling and facilitate megakaryocyte differentiation. [PDF]

, 2016
Most MPN patients lacking JAK2 mutations harbour somatic CALR mutations that are thought to activate cytokine signalling although the mechanism is unclear.
A Franceschini, AL Jackson, AM Whalen, AR Moliterno, B Luo, B Schuster, C Gambacorti-Passerini, C James, C Marty, CM Hobbs, E Avezov, EJ Baxter, FD Bushman, FK Racke, G Manning, G Zauli, H Quentmeier, HJ Park, I Chachoua, IB Weinstein, J Blagg, J Nangalia, J Zhang, JW Tyner, K Kollmann, K Kollmann, LI Gold, M Michalak, MI Davis, MM Zutter, MP Chao, MR Garbati, O Hantschel, P Lahiry, PA Beer, R Guerriero, R Herrera, R Kralovics, R Miyazaki, R Rampal, RL Levine, S Anand, S Fichelson, S Johnson, SG Olthof, SM Greenberg, T Anastassiadis, T Klampfl, W-A Wang, WWY Lau   +49 more
core   +8 more sources