Results 61 to 70 of about 8,227 (218)

PKCθ is dispensable for megakaryopoiesis

Platelets, 2014
Megakaryocytes are large polyploid cells that produce platelets. Megakaryocytes undergo an abbreviated cell cycle (known as endomitosis) that does not proceed to cytokinesis [1].
John C, Kostyak, Satya P, Kunapuli
openaire   +2 more sources

Interstitial 11q Deletions and Terminal 11q Duplications Cause a Bleeding Tendency due to Platelet Dysfunction That Is Similar to 11q Deletions Causing Jacobsen Syndrome

European Journal of Haematology, EarlyView.
ABSTRACT Introduction Jacobsen syndrome, resulting from a terminal deletion of chromosome 11 (11q), may lead to an increased bleeding tendency due to low platelet counts or platelet dysfunction. Currently, information on bleeding tendency and platelet function in patients with nonterminal 11q‐aberrations such as larger deletions, interstitial 11q ...
Elise J. Huisman, Virgil A. S. H. Dalm, Marieke Joosten, Frans J. Smiers, Leendert Porcelijn, Arjan Hoogendijk, Hans Janssen, Nicole N. van der van der Wel, Idske C. L. Kremer Hovinga, Masja de Haas, Marjon H. Cnossen   +10 more
wiley   +1 more source

Abnormal regulation of soluble and anchored IL-6 receptor in monocytes from patients with essential thrombocythemia [PDF]

, 2010
Objective: In a previous study, we found increased plasma soluble receptor for interleukin-6 (sIL-6R) levels in patients with essential thrombocythemia (ET) that could promote megakaryopoiesis through IL-6 binding and further interaction with the signal ...
Alvarez-Larrán, Ana C. Glembotsky, Arellano-Rodrigo, Barillé, Bauer, Baxter, Briso, Carlos D. Chazarreta, Chomczynski, Coles, Felisa C. Molinas, Gallea-Robache, Horiuchi, Jones, Jones, Jones, Jones, Jones, Juan P. Salim, Kralovics, Labbaye, Levine, Levine, Marta, Marta, Matthews, Mitsuyama, Mudter, Mullberg, Murakami-Mori, Murphy, Müllberg, Nakanishi, Nakashima, Nora P. Goette, Pang, Paola R. Lev, Pardanani, Park, Paula G. Heller, Rameshwar, Rosana F. Marta, Rose-John, Sui, Trikha, Varghese, Waetzig, Zheng   +47 more
core   +1 more source

Involvement of ERK1/2, p38 and PI3K in megakaryocytic differentiation of K562 cells [PDF]

, 2013
22 p.-7 fig.Megakaryocytic differentiation of myelogenous leukemia cell lines induced by a number of chemical compounds mimics, in part, the physiological process that takes place in the bone marrow in response to a variety of stimuli.
Conde, Isabel, González-Manchón, Consuelo, Jayo, Asier, Lastres, Pedro, Pabón, Dina   +4 more
core   +2 more sources

Decreased Expression of IL‐35 and Its Receptor Contributes to Impaired Megakaryopoiesis in the Pathogenesis of Immune Thrombocytopenia

Advanced Science
Recent findings have shown that the level of interleukin‐35 (IL‐35) is abnormal in several autoimmune diseases. Nonetheless, whether IL‐35 participates in the pathogenesis of immune thrombocytopenia (ITP) remains unclear.
Xuan Cai, Ruo‐Yun Gui, Jin Wu, Chen‐Cong Wang, Xiao‐Lu Zhu, Hai‐Xia Fu, Xiao‐Hui Zhang   +6 more
doaj   +1 more source

Interleukins in Platelet Biology: Unraveling the Complex Regulatory Network

Pharmaceuticals
Interleukins, a diverse family of cytokines produced by various cells, play crucial roles in immune responses, immunoregulation, and a wide range of physiological and pathological processes.
Miao Huang, Long Wang, Qianhui Zhang, Ling Zhou, Rui Liao, Anguo Wu, Xinle Wang, Jiesi Luo, Feihong Huang, Wenjun Zou, Jianming Wu   +10 more
doaj   +1 more source

Suppressive effects of anthrax lethal toxin on megakaryopoiesis. [PDF]

PLoS ONE, 2013
Anthrax lethal toxin (LT) is a major virulence factor of Bacillus anthracis. LT challenge suppresses platelet counts and platelet function in mice, however, the mechanism responsible for thrombocytopenia remains unclear.
Po-Kong Chen, Hsin-Hou Chang, Guan-Ling Lin, Tsung-Pao Wang, Yi-Ling Lai, Ting-Kai Lin, Ming-Chun Hsieh, Jyh-Hwa Kau, Hsin-Hsien Huang, Hui-Ling Hsu, Chi-Yuan Liao, Der-Shan Sun   +11 more
doaj   +1 more source

Thrombopoietin Receptor Agonists Plus Immunosuppressive Therapy in Aplastic Anaemia: A Systematic Review and Meta‐Analysis

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Background Immunosuppressive therapy (IST) is standard first‐line treatment for severe aplastic anaemia (AA) in patients ineligible for allogeneic transplantation. Thrombopoietin receptor agonists (TPO‐RAs) are increasingly added to IST to improve haematologic recovery, but long‐term safety remains uncertain.
Elham Ashrafi, Lauren Young, Lucy C. Fox, Stephen B. Ting, Erica M. Wood, Zoe K. McQuilten   +5 more
wiley   +1 more source

The Yin and Yang of microRNAs: leukemia and immunity [PDF]

, 2013
Yin and Yang are two complementary forces that together describe the nature of real-world elements. Yin is the dark side; Yang is the light side. We describe microRNAs having both Yin and Yang characteristics because they can contribute to normal ...
Baltimore, David, So, Alex Yick-Lun, Zhao, Jimmy L.   +2 more
core   +1 more source

Rasa3 controls megakaryocyte Rap1 activation, integrin signaling and differentiation into proplatelet. [PDF]

PLoS Genetics, 2014
Rasa3 is a GTPase activating protein of the GAP1 family which targets Ras and Rap1. Ubiquitous Rasa3 catalytic inactivation in mouse results in early embryonic lethality.
Patricia Molina-Ortiz, Séléna Polizzi, Eve Ramery, Stéphanie Gayral, Céline Delierneux, Cécile Oury, Shintaro Iwashita, Stéphane Schurmans   +7 more
doaj   +1 more source