Results 71 to 80 of about 8,227 (218)

Microbiota-Derived Propionate Modulates Megakaryopoiesis and Platelet Function

Frontiers in Immunology, 2022
Rheumatoid arthritis (RA) is associated with an increased risk for cardiovascular events driven by abnormal platelet clotting effects. Platelets are produced by megakaryocytes, deriving from megakaryocyte erythrocyte progenitors (MEP) in the bone marrow.
Kerstin Dürholz, Kerstin Dürholz, Eva Schmid, Eva Schmid, Michael Frech, Michael Frech, Vugar Azizov, Vugar Azizov, Nadine Otterbein, Nadine Otterbein, Sébastien Lucas, Sébastien Lucas, Manfred Rauh, Georg Schett, Georg Schett, Heiko Bruns, Mario M. Zaiss, Mario M. Zaiss   +17 more
doaj   +1 more source

Successful Treatment of Aplastic Anemia With Eltrombopag During Pregnancy: A Short Report

eJHaem, Volume 7, Issue 2, April 2026.
ABSTRACT Introduction Aplastic anemia (AA) is a rare bone marrow failure syndrome with pancytopenia, mainly due to immune‐mediated stem cell destruction. First‐line therapy for acquired severe AA ≥ 50 years/non‐severe AA (NSAA) requiring treatment is immunosuppressive therapy with horse anti‐thymocyte globulin, cyclosporine A (CSA), and eltrombopag ...
Sandra M. Frey, Ferras Alashkar, H. Christian Reinhardt, Alexander Röth   +3 more
wiley   +1 more source

Platelet Apoptosis in Adult Immune Thrombocytopenia: Insights into the Mechanism of Damage Triggered by Auto-antibodies [PDF]

, 2016
Mechanisms leading to decreased platelet count in immune thrombocytopenia (ITP) are heterogeneous. This study describes increased platelet apoptosis involving loss of mitochondrial membrane potential (ΔΨm), caspase 3 activation (aCasp3) and ...
Contrufo, Geraldine, Espasandin, Yesica Romina, García, Alejandro Jorge, Glembotsky, Ana Claudia, Goette, Nora Paula, Grodzielski, Matías, Heller, Paula Graciela, Lev, Paola Roxana, Marta, Rosana Fernanda, Molinas, Felisa Concepción, Pierdominici, Marta S., Riveros, Dardo Alberto   +11 more
core   +1 more source

Unraveling the role of TP53 mutations in myeloproliferative neoplasms: Molecular mechanisms of leukemic transformation

HemaSphere, Volume 10, Issue 3, March 2026.
Abstract TP53 mutations are found in over 50% of tumor types, including myeloproliferative neoplasms (MPNs). MPNs are characterized by a chronic phase, which may progress to secondary acute myeloid leukemia (sAML). Here, we discuss the physiological functions of p53 in hematopoiesis and its deregulation in MPNs.
Suzana da Silva‐Benedito, Paula Sabbo Bernardo, Jean‐Edouard Martin, Caroline Marty, Isabelle Plo, Iléana Antony‐Debré, Bárbara da Costa Reis Monte‐Mór   +6 more
wiley   +1 more source

From Hematopoietic Stem Cells to Platelets: Unifying Differentiation Pathways Identified by Lineage Tracing Mouse Models

Cells
Platelets are the terminal progeny of megakaryocytes, primarily produced in the bone marrow, and play critical roles in blood homeostasis, clotting, and wound healing.
Bryce A. Manso, Alessandra Rodriguez y Baena, E. Camilla Forsberg   +2 more
doaj   +1 more source

Comparative Study on the Effect of Vitamin D Deficiency on Platelet Indices in COVID‐19 and Hepatitis C Patients; an Observational Comparative Study

Health Science Reports, Volume 9, Issue 3, March 2026.
ABSTRACT Background and Aims Despite growing interest in the role of vitamin D in various infectious diseases, limited evidence exists regarding its association with platelet (PLT) parameters in patients with COVID‐19 and Hepatitis C Virus (HCV) infection.
Mohammad Motaghi, Kazem Ghaffari, Mahroo Mansori, Ali Ghasemi   +3 more
wiley   +1 more source

In vitro human embryonic stem cell hematopoiesis mimics MYB-independent yolk sac hematopoiesis [PDF]

, 2014
Although hematopoietic precursor activity can be generated in vitro from human embryonic stem cells, there is no solid evidence for the appearance of multipotent, self-renewing and transplantable hematopoietic stem cells.
De Bleser, Dominique, De Mulder, Katrien, Kerre, Tessa, Lambrecht, Bart, Leclercq, Georges, Menten, Björn, Philippé, Jan, Taghon, Tom, Van Caeneghem, Yasmine, Van Roy, Nadine, Vandekerckhove, Bart, Vanhee, Stijn, Velghe, Imke, Verstichel, Greet   +13 more
core   +3 more sources

Megakaryocytic dysfunction in immune thrombocytopenia is linked to autophagy

Cancer Cell International, 2019
Immune thrombocytopenic purpura (ITP) is a multifactorial autoimmune disease characterized by both increased platelet destruction and/or reduced platelet production.
Rui-jie Sun, Ning-ning Shan
doaj   +1 more source

STIMATE‐Mustn1 Fusion Protein Prevents Ca2+ Overload in Cells That Present Increased SOCE

The FASEB Journal, Volume 40, Issue 4, 28 February 2026.
STIMATE‐mustn1 fused protein expression downregulates Thr‐evoked Ca2+ entry in neonatal platelets. Meanwhile, maternal platelets express the canonical STIMATE, which promotes the Thr‐dependent Ca2+ entry. Impaired Ca2+ entry in neonatal platelets may contribute to the alteration in platelet aggregation found in these subjects. ER, endoplasmic reticulum.
Alejandro Berna‐Erro, Pedro J. Camello, María P. Granados, Elena Delgado, Esperanza Fernández, Raúl Teruel‐Montoya, Francisca Ferrer‐Marín, Juan A. Rosado, Pedro C. Redondo   +8 more
wiley   +1 more source

Mutant calreticulin knockin mice develop thrombocytosis and myelofibrosis without a stem cell self-renewal advantage. [PDF]

, 2018
Somatic mutations in the endoplasmic reticulum chaperone calreticulin (CALR) are detected in approximately 40% of patients with essential thrombocythemia (ET) and primary myelofibrosis (PMF).
Aungier, Juliet, Bennett, Cavan, Dovey, Oliver M, Ghevaert, Cedric, Gonzalez-Arias, Carlos, Green, Anthony R, Grinfeld, Jacob, Hamilton, Tina L, Kent, David G, Klampfl, Thorsten, Li, Juan, Loughran, Stephen, Park, Hyun Jung, Pask, Dean C, Prins, Daniel, Sneade, Rachel, Vassiliou, George S, Williams, Matthew   +17 more
core   +1 more source