Results 11 to 20 of about 98,848 (186)
Cancer Biology & Therapy, 2022 The tumor recurrence and drug resistance of hepatocellular carcinoma (HCC) threatened patients a lot. The mechanism should be further explored. The information of expression status and survival were available in public databases.
Hanpu Zhang +7 more
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NGF activates NFAT via the MEK1/2 pathway in PC12 cells
All Life, 2022 Nerve growth factor (NGF) plays a key role in controlling growth, maintenance and survival of neurons as well as nociceptor development. Many of its critical actions are believed to be mediated by activation of corresponding transcription factors. Here I
Man Su Kim
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The expression of survivin and its related genes in adipocyte-derived stem cell by demethylation [PDF]
Korean Journal of Anesthesiology, 2010 BackgroundSurvivin is thought to contribute to stem cell maintenance partly by a hypomethylation mechanism. This study attempted to elucidate the signal transduction pathway of adipocyte-derived stem cells (ASCs) by using a demethylating agent, 5-aza-2 ...
Kwang Yoon +7 more
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Patient-Centered Design Method for Self-Powered and Cost-Optimized Health Monitors
IEEE Access, 2023 The emergence of Wireless Body Area Networks (WBANs) with health monitoring capabilities has revolutionized health care. Implementing fully independent WBAN nodes is important to the long-term viability of this initiative.
Molly Sharone, Ali Muhtaroglu
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Expert Opinion on Emerging Drugs, 2010 The Ras/Raf/MEK/ERK pathway is often activated by genetic alterations in upstream signaling molecules. Integral components of this pathway such as Ras and B-Raf are also activated by mutation. The Ras/Raf/MEK/ERK pathway has profound effects on proliferative, apoptotic and differentiation pathways.
McCubrey JA +15 more
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Optimizing photoswitchable MEK [PDF]
Proceedings of the National Academy of Sciences, 2019 SignificanceControlling access to the active sites of kinases using photo-dimerizable domains revolutionizes the types of possible optogenetic perturbations of cell signaling. This technology, however, is useful only when there is strong kinase activity to harness.
Aleena L. Patel +6 more
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The board and IT governance: The what, who and how
South African Journal of Business Management, 2010 This paper discusses the importance of corporate governance and the need to implement it effectively in any organization. Furthermore, information technology is discussed along with its impact on enabling an organization to achieve its business goals and
S. Posthumus, R. Von Solms, M. King
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Molecular Cell, 2001 Myogenesis is inhibited by receptor activation of Ras through the MEK and ERK kinases, but the underlying mechanism is unclear. In this issue of Molecular Cell, Perry et al. show that activated MEK1 forms an inhibitory complex with myogenic transcription factors in the nucleus.
Penn, Bennett H. +3 more
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Cell Cycle, 2002 The MEK family of protein kinases plays key roles in regulating cellular responses to mitogens as well as environmental stress. Inappropriate activation of these kinases contributes to tumorigenesis. In contrast, anthrax lethal factor, the principal virulence factor of anthrax toxin, has been demonstrated to selectively inactivate MEKs. In this article
J F, Bodart +3 more
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Atmospheric mixing ratios of methyl ethyl ketone (2-butanone) in tropical, boreal, temperate and marine environments [PDF]
Atmospheric Chemistry and Physics, 2016 Methyl ethyl ketone (MEK) enters the atmosphere following direct emission from vegetation and anthropogenic activities, as well as being produced by the gas-phase oxidation of volatile organic compounds (VOCs) such as n-butane. This study presents the
A. M. Yáñez-Serrano +22 more
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