Results 221 to 230 of about 231,542 (282)

Lung adenocarcinoma with KRAS-Q61H: clinicopathologic features, diagnostics, and the evolving treatment landscape. [PDF]

Front Oncol
Serafimidis I.
europepmc   +1 more source

Spatiotemporal dynamics of β‐arrestin‐mediated Src activation in 5‐HT7 receptor signaling pathway

The FEBS Journal, EarlyView.
GPCRs induce distinct cellular responses via G protein‐ or β‐arrestin‐mediated signaling pathways. This study revealed that β‐arrestin‐biased 5‐HT7R ligand induces slow, sustained Src activation, contrasting with transient G protein‐mediated activation.
Hyunbin Kim, Yong Woo Lee, Huimin Lee, Eunseo Park, Jieon Lee, Hae Nim Lee, Kyeong‐Man Kim, Hyunah Choo, Jihye Seong   +8 more
wiley   +1 more source

Midkine as a therapeutic node in NF1-driven neuro‑oncology: Biology, biomarkers, and translational strategies. [PDF]

Biomed Pharmacother
Nair HB, Subramani R, Lakshmanaswamy R.
europepmc   +1 more source

RAB4A acts as a negative feedback regulator of extracellular vesicle secretion during TGF‐β signaling

The FEBS Journal, EarlyView.
TGF‐β signaling regulates extracellular vesicle (EV) release in cancer cells by modulating the expression and activity of genes associated with EV biogenesis. The TGF‐β‐induced upregulation of RAB4A expression facilitates fast endosomal recycling, a process that limits the fusion of multivesicular bodies with the plasma membrane and EV secretion. Hence,
Dorival Mendes Rodrigues‐Junior, Maria Anastasia Doumani, Hao Fu, Jelle van den Bor, Olof Idevall‐Hagren, Aristidis Moustakas   +5 more
wiley   +1 more source

Targeting the MAPK Pathway in Brain Tumors: Mechanisms and Therapeutic Opportunities. [PDF]

Cancers (Basel)
Vrachas D, Kosma E, Giannopoulou AI, Margoni A, Gargalionis AN, El-Habr EA, Piperi C, Adamopoulos C.   +7 more
europepmc   +1 more source

MEK Inhibitor WX-554 [PDF]

, 2020
openaire   +1 more source

Bank IPOs and Regulations: Cross‐Country Evidence

Financial Review, EarlyView.
ABSTRACT The present paper investigates the effect of banking industry regulations on bank initial public offering (IPO) underpricing. We approach this question from both a micro‐level and macro‐level regulatory perspective. First, we conduct our analysis within a micro framework, focusing on the effect of disclosure rules on IPO underpricing.
Maria‐Eleni K. Agoraki, Dimitrios Gounopoulos, Georgios P. Kouretas   +2 more
wiley   +1 more source

Investigation of exJSRV LTR promoter activity based on transcription factor regulatory networks. [PDF]

Front Vet Sci
Du X, Zhang P, Duan X, Bao A, Ma X, Zhang Y, Liu S.   +6 more
europepmc   +1 more source

Heritage language learners' language availability and choice: A case study of primary school Persian learners in Australia

Foreign Language Annals, EarlyView.
Abstract This study investigates the factors influencing Persian language learning among heritage language learners in Sydney, Australia, with a particular focus on how formal and informal settings shape language choice and availability. The research employs a qualitative case study approach, incorporating data from student focus groups, semi ...
Mojgan Mokhatebi Ardakani, Dara Tafazoli
wiley   +1 more source

Drug Therapy for Melanoma: Current Updates and Future Prospects. [PDF]

Cancers (Basel)
Kato H.
europepmc   +1 more source