Results 31 to 40 of about 98,848 (186)

DNMT1 expression partially dictates 5-Azacytidine sensitivity and correlates with RAS/MEK/ERK activity in gastric cancer cells

Epigenetics, 2023
Though DNMTs inhibitors were widely used in myelodysplastic syndrome and leukaemia, their application in solid tumours has been limited by low response rate and lack of optimal combination strategies.
Zhangqian Chen, Lin Zhang, Yang Yang, Haiming Liu, Xiaoyu Kang, Yongzhan Nie, Daiming Fan   +6 more
doaj   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Comparative Analysis of Energy Efficiency in High-Voltage Ozone Generators: Resonant Versus Non-Resonant Systems

Energies
The effective generation of ozone by high-voltage systems is essential for several industrial and environmental purposes. This paper performs a thorough comparative examination of energy efficiency in ozone generators, emphasizing resonant and non ...
Tongpian Prombud, Ekkapol Anusurain, Chainarong Wisassakwichai, Choosak Kamonkhantithorn   +3 more
doaj   +1 more source

Evidence for an Oceanic Source of Methyl Ethyl Ketone to the Atmosphere

Geophysical Research Letters, 2020
Methyl ethyl ketone (MEK) is a relatively abundant but understudied oxygenated volatile organic compound that can serve as a source of both HOx and PAN when photooxidized.
J. F. Brewer, E. V. Fischer, R. Commane, S. C. Wofsy, B.C. Daube, E. C. Apel, A. J. Hills, R. S. Hornbrook, B. Barletta, S. Meinardi, D. R. Blake, E. A. Ray, A. R. Ravishankara   +12 more
doaj   +1 more source

Tumor treatment with chemo-virotherapy and MEK inhibitor: A mathematical model of Caputo fractional differential operator

Alexandria Engineering Journal, 2023
Mitogen-activated protein kinase (MEK) inhibitors and oncolytic virotherapy are identified as promising cancer therapies that can enhance the efficacy of other cancer treatments.
M. Moksud Alam, S.M.E.K. Chowdhury, J.T. Chowdhury, Mohammad Mahmud Hasan, M.A. Ullah, Shams Forruque Ahmed   +5 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Clean production of methyl ethyl ketone (MEK)

Revista Facultad de Ingeniería Universidad de Antioquia, 2004
Methyl ethyl ketone oxime (MEKO) was obtained by reaction of methyl ethyl ketone (MEK) with ammonia and hydrogen peroxide using titanium silicalite-1 (TS-1) as catalyst. The effect of reaction temperature, type of solvent, molar ratios of NH3/MEK, H2O2/
César Augusto Caro Muñoz, Elkin Antonio Alfonso Sossa, Consuelo Montes de Correa   +2 more
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Range Space and Similarity Transformation Using Symbolic Mathematics in Python

IEEE Access
Linear systems involved in engineering and scientific calculations can be more easily analyzed using similarity transformation. However, understanding the numerous abstract linear algebra theorems associated with this transformation can be challenging ...
Chainarong Wisassakwichai, Prasert Phaochoo   +1 more
doaj   +1 more source

Evolution of melanoma cross-resistance to CD8+ T cells and MAPK inhibition in the course of BRAFi treatment

OncoImmunology, 2018
The profound but frequently transient clinical responses to BRAFV600 inhibitor (BRAFi) treatment in melanoma emphasize the need for combinatorial therapies.
Natalia Pieper, Anne Zaremba, Sonia Leonardelli, Franziska Noelle Harbers, Marion Schwamborn, Silke Lübcke, Barbara Schrörs, Jolanthe Baingo, Alexander Schramm, Sebastian Haferkamp, Ulrike Seifert, Antje Sucker, Volker Lennerz, Thomas Wölfel, Dirk Schadendorf, Bastian Schilling, Annette Paschen, Fang Zhao   +17 more
doaj   +1 more source