Allele-Specific GNAQ Q209 Mutations Reveal Context-Dependent Oncogenic Programs in Uveal Melanoma. [PDF]
Pigment Cell Melanoma ResUsing matched immune‐competent, multistep uveal melanoma models, we show that GNAQ Q209L and Q209R mutations are not functionally equivalent. Q209L drives faster in vivo progression but reduces in vitro proliferation and migration, whereas Q209R promotes greater in vitro fitness and preferential FAK‐YAP activation, revealing an allele‐dependent ...
Jarajapu V +5 more
europepmc +2 more sources
Rapidly Progressive Metastatic Sertoli Cell Tumor Associated With an Adenomatous Polyposis Coli Mutation: A Case Report and Literature Review. [PDF]
IJU Case RepABSTRACT Introduction Sertoli cell tumors are rare testicular sex cord‐stromal tumors, and clinically malignant behavior is uncommon. We report a rapidly progressive metastatic Sertoli cell tumor associated with an APC mutation. Case Presentation A 27‐year‐old man with familial adenomatous polyposis (FAP) presented with painless right scrotal ...
Obayashi K +9 more
europepmc +2 more sources
Cytological Features of Clear Cell Sarcoma in Exfoliative and Effusion Cytology Specimen-A Case Report and Literature Review. [PDF]
Diagn CytopatholABSTRACT Clear cell sarcoma of soft tissue (CCSST) with malignant effusion is a rare yet clinically aggressive appearance, which may pose a diagnostic pitfall with its overlapping cytomorphologic features with metastatic melanoma and carcinoma.
Wu WH, Ng JKM, Li JJX.
europepmc +2 more sources
Medullary Thyroid Carcinoma Showing Melanocytic Differentiation: A Report of a Rare Case
Endocrinology Research and Practice, 2015 Medullary thyroid carcinoma (MTC) accounts for 5-10% of all thyroid malignancies. These tumors show variable morphological features, however, to the best of our knowledge, melanocytic differentiation is rare with only 11 reported cases.
Serap Karaarslan +5 more
doaj +1 more source
On the peculiarities of seborrheic keratosis pigmentation
Vestnik Dermatologii i Venerologii, 2019 Seborrheic keratosis (SK) is a common benign epithelial skin tumor that exists in a variety of clinical op - tions. The color of the tumor varies from yellow to dark brown, which leads to diagnostic errors. There is аlittle data about pigmentation of the
A. K. Alexandrova, V. A. Smolyannikova
doaj +1 more source
Melanoma of unknown primary origin metastasizing to visceral organs in a sheep
Brazilian Journal of Veterinary Pathology, 2018 Malignant melanomas are quite uncommon in sheep and goats. A three-year-old native female sheep with a history of sudden death was referred for postmortem examination.
Ahmad Oryan +3 more
doaj +1 more source
Primary Melanoma of the Lung: A Systematic Review
Medicina, 2020 Background and Objectives: The respiratory apparatus, generally affected by highly aggressive tumors like lung cancer and mesothelioma, is rarely affected by primary malignant melanoma.
Panagiotis Paliogiannis +7 more
doaj +1 more source
Marine Drugs, 2016 Tyrosinase is the rate-limiting enzyme critical for melanin synthesis and controls pigmentation in the skin. The inhibition of tyrosinase is currently the most common approach for the development of skin-whitening cosmetics.
Ho Yeon Lee +6 more
doaj +1 more source
SOX11, SOX10 and MITF Gene Interaction: A Possible Diagnostic Tool in Malignant Melanoma
Life, 2021 Malignant melanoma (MM) is a highly heterogenic tumor whose histological diagnosis might be difficult. This study aimed to investigate the diagnostic and prognostic utility of the conventional pan-melanoma cocktail members (HMB-45, melan-A and tyrosinase)
Marius-Alexandru Beleaua +4 more
doaj +1 more source
ACTIVATED CHARCOAL: A NATURAL PROTECTIVE MEASURE AGAINST THE LINGUAL DEGENERATIVE EFFECT OF TACROLIMUS IMMUNOSUPPRESSANT [PDF]
Alexandria Dental JournalObjective: The presented work was conducted to test the effectiveness of activated charcoal on the lingual mucosa of male rats subjected to the immunosuppressive drug tacrolimus.
Hagar Abdel Fattah +2 more
doaj +1 more source