Results 81 to 90 of about 60,342 (231)

Palmitate‐induced impairment of melanocortin‐4 receptor

The FASEB Journal, 2013
Obese patients, and diet induced obese rodents, exhibit elevated palmitate in the blood stream and hypothalamus. Elevated palmitate has been found to attenuate hypothalamic insulin signaling, and this effect is thought to be mediated through endoplasmic reticulum (ER) stress.
Faith Kennedy McDaniel, Giulia Baldini
openaire   +1 more source

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

L-Cell Expression of Melanocortin-4-Receptor Is Marginal in Most of the Small Intestine in Mice and Humans and Direct Stimulation of Small Intestinal Melanocortin-4-Receptors in Mice and Rats Does Not Affect GLP-1 Secretion

Frontiers in Endocrinology, 2021
The molecular sensors underlying nutrient-stimulated GLP-1 secretion are currently being investigated. Peripheral administration of melanocortin-4 receptor (MC4R) agonists have been reported to increase GLP-1 plasma concentrations in mice and humans but ...
Rune E. Kuhre, Rune E. Kuhre, Rune E. Kuhre, Ida M. Modvig, Ida M. Modvig, Sara L. Jepsen, Sara L. Jepsen, Hüsün S. Kizilkaya, Cecilie Bæch-Laursen, Cecilie Bæch-Laursen, Christopher A. Smith, Frank Reimann, Fiona M. Gribble, Mette M. Rosenkilde, Jens J. Holst, Jens J. Holst   +15 more
doaj   +1 more source

Melanocortin Pathways: Suppressed and Stimulated Melanocortin-4 Receptor (MC4R)

Physiological Research, 2020
Leptin-melanocortin pathway plays an essential role in the body weight regulation. Enhanced melanocortin signaling in the hypothalamus results in both decreased food intake and increased energy expenditure. The discovery of monogenic obesities with dysfunction of melanocortin-4 receptor (MC4R) greatly contributed to understanding of energy balance ...
V, Hainer, I, Aldhoon Hainerová, M, Kunešová, R, Taxová Braunerová, H, Zamrazilová, B, Bendlová   +5 more
openaire   +2 more sources

Motivational valence is determined by striatal melanocortin 4 receptors [PDF]

Journal of Clinical Investigation, 2018
It is critical for survival to assign positive or negative valence to salient stimuli in a correct manner. Accordingly, harmful stimuli and internal states characterized by perturbed homeostasis are accompanied by discomfort, unease, and aversion. Aversive signaling causes extensive suffering during chronic diseases, including inflammatory conditions ...
Anna Mathia Klawonn, Michael Fritz, Anna Nilsson, Jordi Bonaventura, Kiseko Shionoya, Elahe Mirrasekhian, Urban Karlsson, Maarit Jaarola, Björn Granseth, Anders Blomqvist, Michael Michaelides, David Engblom   +11 more
openaire   +5 more sources

A genetically informed cross‐lagged twin study of the longitudinal association between addiction‐related behaviors and obesity

Addiction, EarlyView.
Abstract Background and aims Addiction‐related behaviors, such as loss of control eating (LOC), cigarette smoking and alcohol consumption, have been associated with high body mass index (BMI). This study aimed to assess genetic and environmental contributions to these associations over time.
Baiyu Qi, Heather M. Highland, Mariaelisa Graff, Cynthia M. Bulik, Soo Hyun Rhee, Michael C. Stallings, John K. Hewitt, Daniel E. Gustavson, Chandra A. Reynolds, Kari E. North, Melissa A. Munn‐Chernoff   +10 more
wiley   +1 more source

Glucose Intake during the Neonatal Period Modulates the Central Melanocortin System with Breed-Specific Differences

The Journal of Poultry Science
Glucose is the primary substrate for cellular energy production, and its blood concentration is tightly regulated. This study investigated the effect of glucose supplementation during the first three days post-hatching on growth performance and ...
Kazuki Kimura, Yuuna Watanabe, Sachi Ashizawa, Koichi Matsushita, Nobuhiro Nakao, Yoshiyuki Ohta, Jun-ichi Shiraishi   +6 more
doaj   +1 more source

MRAP2 regulates energy homeostasis by promoting primary cilia localization of MC4R

JCI Insight, 2023
The G protein–coupled receptor melanocortin-4 receptor (MC4R) and its associated protein melanocortin receptor–associated protein 2 (MRAP2) are essential for the regulation of food intake and body weight in humans.
Adelaide Bernard, Irene Ojeda Naharros, Xinyu Yue, Francois Mifsud, Abbey Blake, Florence Bourgain-Guglielmetti, Jordi Ciprin, Sumei Zhang, Erin McDaid, Kellan Kim, Maxence V. Nachury, Jeremy F. Reiter, Christian Vaisse   +12 more
doaj   +1 more source

Hypothalamic gene expression during voluntary hypophagia in the Sprague-Dawley rat on withdrawal of the palatable liquid diet, Ensure [PDF]

, 2014
Copyright © 2014 Elsevier Inc.
Archer, Zoe A, Duncan, Jacqueline S, Mercer, Julian G   +2 more
core   +1 more source

Age‐specific melanoma risk associated with nevi: a pooled analysis from the M‐SKIP project

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Objective This study investigates the association of melanoma risk with total‐body nevus count and the presence of atypical nevi in younger (< 40 years) and older (> 60 years) individuals. Methods A pooled analysis was conducted within the M‐SKIP project, based on multiple melanoma case‐control studies.
Giulia Doi, Aurora Gaeta, Simone Ribero, Nelleke Gruis, Julia Newton‐Bishop, David Polsky, DeAnn Lazovich, Paola Ghiorzo, Gloria Ribas, Chiara Menin, Alexander J. Stratigos, Gabriella Guida, Susana Puig, Maria Concetta Fargnoli, Peter A. Kanetsky, Paola Queirolo, Vincenzo Bagnardi, Veronique Bataille, Sara Raimondi, Sara Gandini, M‐SKIP study group   +20 more
wiley   +1 more source