Results 81 to 90 of about 46,881 (189)

Pro-Opiomelanocortin and Melanocortin Receptor 3 and 4 Mutations in Genetic Obesity

Biomolecules
Genetic obesity results from loss-of-function mutations, including those affecting the leptin–melanocortin system, which regulates body weight. Pro-opiomelanocortin (POMC)-derived neurohormones act as ligands for melanocortin receptors (MCRs), regulating
Tulin Yanik, Seyda Tugce Durhan
doaj   +1 more source

Striking Suture Zone Mismatch Between Nuclear and Mitochondrial Markers in North African Chalcides ocellatus (Squamata: Scincidae)

Zoologica Scripta, EarlyView.
ABSTRACT Linnaean and Wallacean shortfalls remain pervasive even among common and widespread Mediterranean taxa, limiting our understanding of evolutionary history and species boundaries. The Ocellated Skink Chalcides ocellatus complex illustrates this issue, with disputed subspecific taxonomy and deep mitochondrial divergences across North Africa and ...
Paul Doniol‐Valcroze, Dave Lutgen, Menad Beddek, Boualem Dellaoui, Philippe Geniez, Olivier Peyre, Patricia Sourrouille, Pierre‐André Crochet   +7 more
wiley   +1 more source

Through the Sands of Time: Evolutionary History and Systematics of the Awl‐Headed Snakes (Colubridae: Lytorhynchus) in the Saharo‐Sindian Region

Zoologica Scripta, EarlyView.
ABSTRACT The psammophilous colubrid genus Lytorhynchus is widely distributed in the deserts of the Saharo‐Sindian region and adjacent areas. The taxonomy of the genus and the number of recognised species have remained unstable since the last taxonomic revision in 1970, with differing views on the taxonomic status of L. gaddi and L. kennedyi.
Lukáš Pola, Daniel Jablonski, Rafaqat Masroor, Bassam Abu Afifeh, Roberta Graboski, Mohammad Abu Baker, Zuhair S. Amr, Ahmed Mohajja AlShammari, Avrajjal Ghosh, Salvador Carranza, Jiří Šmíd   +10 more
wiley   +1 more source

Maternal nutrition as a key determinant of placental and developing blood–brain barrier xenobiotic protective functions

The Journal of Physiology, EarlyView.
Abstract figure legend Suboptimal maternal nutrition alters placental and developing blood–brain barrier (BBB) protective function and is associated with increased fetal brain vulnerability. In the placenta, nutritional adversity may reduce the exchange surface area and promote meta‐inflammation, compromising barrier efficiency in a model‐ and context ...
Kristin L. Connor, Nycolle I. S. Souza, Bruno G. Anjos, Stephen G. Matthews, Enrrico Bloise   +4 more
wiley   +1 more source

Understanding the Molecular Processes of Obesity and the Anti‐Obesity Properties of Bioactive Substances Found in Tea

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
ABSTRACT Obesity, a severe worldwide health concern, is characterized as an excessive deposit of fat in the human body. It has various ramifications that endanger human health and increase the financial expense. Obesity raises the risk of several illnesses, notably cardiovascular disease, NALFD, and diabetes, and has been associated with shorter ...
Sakhawat Riaz, Fan Wenni, Danish Kamal, Umber Mubeen, Abul Hassan, Arslan Ahmed, Munir Ahmed   +6 more
wiley   +1 more source

Molecular Mechanisms of Food Bioactive Constituents in the Management of Obesity and Hypertension: A Critical Review

Phytochemicals in Food and Medicine, Volume 1, Issue 3, September 2026.
Obesity and hypertension co‐exist and share molecular mechanisms in terms of dietary therapy, modulated by food bioactive constituents. ABSTRACT Obesity and hypertension are among the most pressing global public health challenges. They frequently co‐exist, with obesity‐related hypertension accounting for an estimated 75% of the hypertension burden ...
Samuel Oluwasegun Maccarthy, Emmanuel Anyachukwu Irondi, Abdulazeez Olamilekan Elemosho, Emmanuel Oladipo Ajani   +3 more
wiley   +1 more source

Association of Melanocortin 4 Receptor gene polymorphism with growth traits in Bligon goat

Journal of the Indonesian Tropical Animal Agriculture, 2018
Melanocortin 4 receptor gene is a potential marker gene for growth performance in ruminant and non-ruminant animals. The objective of this study was to perform allele and genotype frequencies, and association of melanocortin 4 receptor with growth traits
L. Latifah, D. Maharani, A. Kustantinah, T. Hartatik   +3 more
doaj   +1 more source

Positioning Incretin‐Based and Next‐Generation Obesity Management Medications: A Methodological Framework for a Series of Systematic Reviews and Network Meta‐Analyses

Diabetes, Obesity and Metabolism, Volume 28, Issue 9, Page 7768-7778, September 2026.
ABSTRACT Background The obesity pharmacotherapy landscape is evolving rapidly, with several approved incretin‐based therapies and an expanding pipeline of investigational compounds targeting multiple metabolic pathways. Conventional evidence syntheses often struggle to accommodate differences in dose selection, treatment duration and stage of clinical ...
Matteo Monami, Benedetta Ragghianti, Edoardo Mannucci   +2 more
wiley   +1 more source

Obesity Disrupts CtBP2‐Mediated Maintenance of Transcriptional Equilibrium in Hypothalamic Feeding Circuitry

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
CtBP2, a transcriptional corepressor with metabolite sensing capabilities, maintains feeding homeostasis by preventing excessive food intake in the hypothalamic feeding center. CtBP2 limits food intake by inhibiting KLF4 within AgRP neurons and by promoting the inhibitory influence of POMC neurons on AgRP neurons.
Wanpei Chen, Kenta Kainoh, Kenji Saito, Takaaki Matsuda, Daichi Yamazaki, Yuto Kobari, Ayumi Nakata, Nao Aono‐Soma, Takafumi Miyamoto, Yuki Murayama, Yoko Sugano, Yoshinori Osaki, Hitoshi Iwasaki, Takashi Matsuzaka, Hitoshi Shimano, Motohiro Sekiya   +15 more
wiley   +1 more source

Metabolic Regulation of Macrophages in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang, Yu Zhang, Jiali Min, Jiahui Yang, Yuchen Li, Hao Zhang, Shanshan Liu   +6 more
wiley   +1 more source