Results 91 to 100 of about 46,881 (189)

The Clinical Phenotype and Genetic Analysis of Monogenic Non Syndromic Obesity Caused by MC4R Gene Variation

Molecular Genetics &Genomic Medicine, Volume 14, Issue 8, August 2026.
A novel MC4R mutation (c.185A > G) was identified in a 10‐year‐old girl with severe obesity and hyperinsulinemia. Retrospective analysis of 64 pediatric cases revealed that mutation location influences BMI, modulated by underlying disease status, demonstrating that the genotype–phenotype relationship in MC4R‐associated obesity is clinically context ...
Xin Li, Xiaotian Wang, Xin Liu, Shuping Wang, Wentao Yang   +4 more
wiley   +1 more source

Melanocortin-4 Receptor in Fish: A Review

International Journal of Agricultural Science and Food Technology, 2017
The melanocortin-4 receptor (MC4R) belongs to the melanocortin system, has been well investigated in mammals. Which plays important roles in several physiological processes, such as regulating energy homeostasis, cachexia, cardiovascular function, glucose and lipid homeostasis, reproduction and sexual function, drug abuse, pain perception, brain ...
openaire   +1 more source

The Synthetic Melanocortin Agonist NDP‐MSH Ameliorates THSD7A‐Associated Membranous Nephropathy in an Active Immunization Mouse Model

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Active immunization with recombinant THSD7A in mice induces autoreactive B cell activation and differentiation into CD138+ antibody‐secreting cells, leading to the production of anti‐THSD7A autoantibodies, glomerular immune injury and proteinuria, characteristic of membranous nephropathy. NDP‐MSH treatment modulates the MITF/IRF4 axis in primed B cells,
Mingzhuo Zhang, Mengxuan Chen, Yan Ge, William Gunning, Rujun Gong   +4 more
wiley   +1 more source

Dual activation of MC3R and MC4R drives weight loss and reduces food intake in male primates with obesity

Nature Communications
The melanocortin system plays a central role in regulating hunger and satiety, making it an attractive target for treating metabolic disease. However, the limited clinical success of selective melanocortin-4 receptor (MC4R) agonists has prompted ...
Jillian L. Seiler, Anna C. Impastato, Emma Xiaoyu Zhang, Kade J. Kelley, Thomas L. Bennett, Bradley Studnitzer, Claudia R. Prindle, Benjamin H. Rajewski, Barry A. Badeau, Xinjian Jiang, Russell Potterfield, Jordan Y. Delev, Daniel L. Marks   +12 more
doaj   +1 more source

Association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken

Poultry Science
This study aimed to detemine association of central α-klotho with dopaminergic and melanocortin receptors on feed intake regulation in chicken. 264 meat-type chicken were included 6 experiments, each containing 4 groups.
Yaser Hassania, Shahin Hassanpour, Morteza Zendehdel, Bita Vazir   +3 more
doaj   +1 more source

Supraphysiological Glucocorticoid Doses and Pitfalls of Annual Biomarker Monitoring in Adults With CAH

Clinical Endocrinology, Volume 105, Issue 3, Page 360-362, September 2026.
Jakob Bolinder, Oskar Ragnarsson, Gudmundur Johansson   +2 more
wiley   +1 more source

Melanocortin 4 Receptor Deficiency [PDF]

, 2020
openaire   +1 more source

Expression of human melanocortin 4 receptor in Saccharomyces cerevisiae

Open Life Sciences, 2011
Ignatovica Vita, Petrovska Ramona, Fridmanis Davids, Klovins Janis   +3 more
doaj   +1 more source

Melanocortin 4 receptor (MC4R) [PDF]

Science-Business eXchange, 2009
openaire   +1 more source

Melanocortin 4 receptor (MC4R) [PDF]

Science-Business eXchange, 2008
openaire   +1 more source