Results 111 to 120 of about 60,342 (231)

Folding, misfolding, and regulation of intracellular traffic of G protein‐coupled receptors involved in the hypothalamic–pituitary–gonadal axis

Andrology, Volume 14, Issue 4, Page 978-991, May 2026.
Abstract Background G protein‐coupled receptors are a large and functionally diverse family of membrane receptors involved in a number of biological processes. Like other proteins, G protein‐coupled receptors need to be properly folded in order to traffic to the plasma membrane and interact with agonist.
Alfredo Ulloa‐Aguirre, Ross C. Anderson, Teresa Zariñán, Rubén Gutiérrez‐Sagal, Eduardo Jardón‐Valadez, Claire L. Newton   +5 more
wiley   +1 more source

Global consensus on the management of melanin hyperpigmentation disorders

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 5, Page 760-772, May 2026.
A global Delphi consensus of 10 dermatology experts established evidence‐based recommendations for melanin hyperpigmentation disorders, providing unified classification, photoprotection guidance and treatment algorithms. This framework harmonizes terminology and supports individualized management across diverse skin types and health systems.
Thierry Passeron, Seemal R. Desai, Marwa Abdallah, Firas Al‐Niaimi, Ncoza Dlova, Pearl E. Grimes, Jorge Ocampo‐Candiani, Rashmi Sarkar, Leihong Flora Xiang, Helio Amante Miot   +9 more
wiley   +1 more source

Melanocortin-4 Receptor Polymorphisms in Turkish Pediatric Obese Patients

Clinical and Applied Thrombosis/Hemostasis, 2010
The most common Melanocortin-4 receptor (MC4R) missense variant Val103Ileu (rs2229616) is related to obesity. In this study, we examined the distribution of MC4R polymorphisms both in the clinical pediatric obese group and in the high/lowsocioeconomic school group.
Duygu Ozel, Demiralp, Merih, Berberoglu, Nejat, Akar   +2 more
openaire   +2 more sources

Defining Acquired Hypothalamic Obesity: An Expert Call for Unified Diagnosis and Therapeutic Action

Diabetes, Obesity and Metabolism, EarlyView.
Hanneke M. van Santen, Ashley H. Shoemaker, Mehul T. Dattani, Christian L. Roth, Mohamad Maghnie, Kevin C. J. Yuen, Christine Poitou, Hermann L. Müller   +7 more
wiley   +1 more source

Melanocortin 3 Receptors Do Not Specifically Localize to Primary Cilia in Cultured Human and Rodent Neurons

Cell Biochemistry and Function, Volume 44, Issue 4, April 2026.
ABSTRACT The melanocortin‐3 receptor (MC3R) and the melanocortin‐4 receptor (MC4R), both expressed in hypothalamic nuclei, are key downstream effectors of leptin signaling and play important roles in energy homeostasis. While pathogenic variants in the MC4R gene represent the most common cause of monogenic obesity, the clinical significance of MC3R ...
Niels Vos, Alessandro Moro, Wim Van Hul, Lotte Kleinendorst, Ralph J. Florijn, Susanne E. la Fleur, Matthijs Verhage, Mieke M. van Haelst, Ruud F. Toonen   +8 more
wiley   +1 more source

Old drugs with new skills: fenoprofen as an allosteric enhancer at melanocortin receptor 3 [PDF]

, 2016
This project was supported by Queen Mary Innovation Ltd Proof of Concept Fund (2012/13) and The William Harvey Research ...
Cook, JM, Forfar, RAE, Jerman, JC, Montero-Melendez, T, Perretti, M, Taylor, DL   +5 more
core   +1 more source

Associations of MC1R Substitutions With Body Color Variation in a Desert Lizard

Ecology and Evolution, Volume 16, Issue 4, April 2026.
We successfully identified two amino acid substitutions (V165I and V237I) in MC1R that are significantly associated with body color variation between melanistic and non‐melanistic populations of a toad‐headed lizard, P. versicolor. In silico analysis revealed that both substitutions located in transmembrane (TM) domains affect the binding affinity ...
Haojie Tong, Qianjin Lin, Shuangyue Shi, Kaixin Wang, Yaxin Guo, Richard P. Brown, Yuanting Jin   +6 more
wiley   +1 more source

Melanocortin 4 Receptor Gene Sequence Analyses in Diverse Populations

Genetic Testing and Molecular Biomarkers, 2019
Background: Melanocortin 4 receptor (MC4R) is a G-protein-coupled receptor involved in appetite regulation. Mutations in the MC4R gene are the most common cause of monogenic obesity. More than 200 sequence variants in the MC4R gene have been associated with obesity, although the vast majority of these data have been obtained from populations of ...
Michael A, Edwards, Tiffany, Tattoli, Gagan, Sureja, Aaron, Sykes, Scott, Kaniper, Glenn S, Gerhard   +5 more
openaire   +3 more sources

Comparative Evaluation of R134a and HFO‐1234ze Cryogen Spray Cooling Using a Mouse Model With Controllable Epidermal Pigmentation

Lasers in Surgery and Medicine, Volume 58, Issue 4, Page 343-355, April 2026.
ABSTRACT Objectives Cryogen spray cooling (CSC) is critical for protecting the epidermis during laser dermatologic procedures. The widely used cryogen, R134a, has a high global warming potential (GWP), motivating interest in environmentally favorable alternatives such as HFO‐1234ze.
Wangcun Jia, Yurie Jeong, Crystal Huynh, Oswald Lai, Emily Nguyen, Grant Swajian, Jade Niu, Ayana Kashikar, Joshua Khaw, Hong Pu, Bernard Choi, John D'Orazio, J. Stuart Nelson, Bahman Anvari   +13 more
wiley   +1 more source

Pro-Opiomelanocortin and Melanocortin Receptor 3 and 4 Mutations in Genetic Obesity

Biomolecules
Genetic obesity results from loss-of-function mutations, including those affecting the leptin–melanocortin system, which regulates body weight. Pro-opiomelanocortin (POMC)-derived neurohormones act as ligands for melanocortin receptors (MCRs), regulating
Tulin Yanik, Seyda Tugce Durhan
doaj   +1 more source