Results 121 to 130 of about 60,342 (231)

Effect of NDP-a-MSH on PPAR-c and –b Expression and Anti-Inflammatory Cytokine Release in Rat Astrocytes and Microglia [PDF]

, 2013
Brain inflammation plays a central role in numerous brain pathologies. Microglia and astrocytes are the main effector cells that become activated when an inflammatory process takes place within the central nervous system. a-melanocytestimulating hormone (
Carniglia, Lila, Caruso, Carla Mariana, Durand, Daniela Elizabeth, Lasaga, Mercedes Isabel   +3 more
core   +1 more source

Time‐Restricted Feeding Alters Behavior in a Sex‐Specific Manner in Mice With Neuropathic Pain

Molecular Nutrition &Food Research, Volume 70, Issue 8, 27 April 2026.
Time‐restricted feeding (TRF) alleviates anxiety‐like behavior in male mice with neuropathic pain (NP), but not in females. Upon nerve injury, TRF altered the diurnal expression of transcripts in the hypothalamus. These findings suggest that TRF should be explored as a new therapeutic approach to alleviate the comorbid anxiety in NP.
Manqing Wen, Wenjing Dai, Eija Kalso, Vinko Palada   +3 more
wiley   +1 more source

Joint TOS/OMA/OAC Expert Guidance Statement on the Pharmacological Management of United States Adults With Overweight or Obesity Using the GRADE Approach

Obesity, Volume 34, Issue 4, Page 851-870, April 2026.
Guidance recommendations by TOS/OMA/OAC for the use of obesity medications to treat obesity and its complications. ABSTRACT Background Obesity affects over 40% of US adults, with severe obesity on the rise. Despite recognition of obesity as a chronic disease, it remains underdiagnosed and undertreated.
Lydia Alexander, Jonathan Q. Purnell, Karlijn Burridge, Marc‐André Cornier, Angela Golden, Deborah Bade Horn, Michelle Look, Joe Nadglowski, Camila Ávila‐Oliver, Francisco Novillo, Ana María Rojas‐Gómez, Brad Hussey, Ximena Ramos Salas   +12 more
wiley   +1 more source

CNS Control of Glucose Metabolism: Response to Environmental Challenges [PDF]

, 2013
Over the last 15 years, considerable work has accumulated to support the role of the CNS in regulating postprandial glucose levels. As discussed in the first section of this review, the CNS receives and integrates information from afferent neurons ...
Arble, Deanna M., Sandoval, Darleen A.
core   +1 more source

Both MC1 and MC3 Receptors Provide Protection From Cerebral Ischemia-Reperfusion-Induced Neutrophil Recruitment. [PDF]

, 2015
Objective Neutrophil recruitment is a key process in the pathogenesis of stroke, and may provide a valuable therapeutic target. Targeting the melanocortin receptors (MC) has previously shown to inhibit leukocyte recruitment in peripheral inflammation ...
Cooper, D., Cooper, D., Cvek, U., Cvek, U., Durrenberger, P.F., Durrenberger, P.F., Gavins, F.N., Gavins, F.N., Getting, S.J., Getting, S.J., Holloway, P.M., Holloway, P.M., Orr, A.W., Orr, A.W., Perretti, M., Perretti, M., Trutschl, M., Trutschl, M.   +17 more
core   +1 more source

Melanocortin-4 Receptor Gene Mutations in Obese Slovak Children

Physiological Research, 2015
The most common etiology of non-syndromic monogenic obesity are mutations in gene for the Melanocortin-4 receptor (MC485) with variable prevalence in different countries (1.2-6.3 % of obese children). The aim of our study was 1) to search for MC4R mutations in obese children in Slovakia and compare their prevalence with other European countries, and 2)
D, Stanikova, M, Surova, L, Ticha, M, Petrasova, D, Virgova, M, Huckova, M, Skopkova, D, Lobotkova, L, Valentinova, M, Mokan, J, Stanik, I, Klimes, D, Gasperikova   +12 more
openaire   +2 more sources

Genetic Legacy of the Last Ice Age Shapes Shallow Phylogeographic Structure in a Widespread Mediterranean Snake

Journal of Biogeography, Volume 53, Issue 4, April 2026.
ABSTRACT Aim Mediterranean peninsulas typically harbour high intraspecific genetic diversity associated with long‐term persistence in multiple glacial refugia. However, some widespread taxa show unexpectedly shallow phylogeographic structure. Here, we investigate which historical processes can generate a pattern of strong genetic depletion within a ...
Daniele Salvi, Luís Machado, Juan Manuel Pleguezuelos, Marc Cheylan, Miguel A. Carretero, David James Harris   +5 more
wiley   +1 more source

Association of Melanocortin 4 Receptor gene polymorphism with growth traits in Bligon goat

Journal of the Indonesian Tropical Animal Agriculture, 2018
Melanocortin 4 receptor gene is a potential marker gene for growth performance in ruminant and non-ruminant animals. The objective of this study was to perform allele and genotype frequencies, and association of melanocortin 4 receptor with growth traits
L. Latifah, D. Maharani, A. Kustantinah, T. Hartatik   +3 more
doaj   +1 more source

Noradrenergic inhibition of definitive POMC neurons through direct and indirect mechanisms

Journal of Neuroendocrinology, Volume 38, Issue 4, April 2026.
Norepinephrine and the α2‐adrenoceptor agonist UK 14,304 robustly inhibit definitive arcuate POMC neurons. Direct inhibition is mediated by ADRA2A‐dependent activation of potassium conductances, while additional indirect mechanisms also contribute. In vivo, inducible POMC‐specific Adra2a deletion minimally affects energy balance and modestly impairs ...
Olivier Lavoie, Audrey Turmel, Axelle Khouma, Moein Minbashi Moeini, Chen Liu, Natalie J. Michael, Alexandre Caron   +6 more
wiley   +1 more source

Adrenalectomy alters the sensitivity of the central nervous system melanocortin system [PDF]

, 2003
Removal of adrenal steroids by adrenalectomy (ADX) reduces food intake and body weight in rodents and prevents excessive weight gain in many genetic and dietary models of obesity. Thus, glucocorticoids appear to play a key role to promote positive energy
Clegg, DJ, Drazen, Deborah L., Drazen, DL, Schwartz, Michael W., Schwartz, MW, Seeley, Randy J., Seeley, RJ, van Dijk, G, Woods, SC, Woods, Stephen C., Wortman, Matthew D., Wortman, MD   +11 more
core   +2 more sources